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This manual is designed primarily to be of assistance to trainee nuclear medicine technicians and radiographers. It will also be of value to those who are already trained in the safe handling and use of radionuclides for imaging, as a rapid reference for routine and non-routine nuclear medicine imaging procedures. The procedures described were largely developed or modified at the Nuclear Medicine Department, Guy's Hospital, London, with regular updates during the last 10 years. The main body of each chapter deals with the technical aspects of radionuclide imaging and each chapter contains a section on the prepara tion procedure for the relevant radiopharmaceuticals used with brief summaries of the aim of any data analyses using a computer system. Although the methods described do not represent the only way to carry out such procedures, they have all been evaluated extensively and are known to give satisfactory results. I would like to record my thanks to all members of this department who have helped by providing advice, comments and data. In particular, I would like to thank Dr Colin Lazarus for his help with the radiopharmaceuticals sections. I am most grateful to Dr Sue Clarke and Dr Ignac Fogelman for checking the manuscripts and finally to Professor Michael Maisey without whose constant encouragement and support this work would not have been possible. FOREWORD The development of nuclear medicine was initially a slow process.