Guoan Luo, Yiming Wang, Qionglin Liang, Qingfei Liu

Systems Biology for Traditional Chinese Medicine

• Gebundenes Buch

Produktbeschreibung

The application of systems biology methods to Traditional Chinese Medicine
Emphasizing the harmony of the human body with the environment, Traditional Chinese Medicine (TCM) has evolved over thousands of years. It is a systemic theory derived from clinical experience, the philosophy of holism and systematology, and the belief that man is an integral part of nature.
Systems Biology for Traditional Chinese Medicine describes how the latest methods in systems biology can be applied to TCM, providing a comprehensive resource for the modernization and advancement of TCM as well as general drug discovery efforts. It is the first comprehensive work to propose a system-to-system research methodology to study the interaction between TCM and the human body and its applications in drug research and development.
Using three popular traditional Chinese medicines--Shuanglongfang, Qingkailing, and Liushenwan--as examples, the authors set forth case examples demonstrating how to find material groups, perform efficacy screenings, and conduct safety evaluations of TCM. The book also:
Describes the mechanisms of TCM at the molecular and systems levels using chemomics, genomics, proteomics, metabolomics, and bioinformatics
Places modern scientific technologies within the context of TCM, helping drug researchers improve experimental designs and strategies
Illustrates how a systems biology approach is compatible with TCM's traditional, holistic therapeutic strategies and treatment modalities
Presents topics of current interest, such as integrated global systems biology and the application of chemometrics research to herbal medicines
This book not only opens a new pathway for the continued development of TCM, but also for systems biology. In addition, it fosters collaboration and discussion among Eastern and Western scientists by applying systems biology to TCM.

Produktdetails

• Verlag: Wiley & Sons
• Artikelnr. des Verlages: 14563797000
• 1. Auflage
• Seitenzahl: 512
• Erscheinungstermin: 3. Juli 2012
• Englisch
• Abmessung: 238mm x 163mm x 32mm
• Gewicht: 848g
• ISBN-13: 9780470637975
• ISBN-10: 0470637978
• Artikelnr.: 35046459

Autorenporträt

GUOAN LUO is Professor in the Institute of Biomedicine and Director of the Modern Research Center for Traditional Chinese Medicine at Tsinghua University in Beijing. Professor Luo is dedicated to the application of systems biology to study and advance TCM. He has published more than 680 peer-reviewed papers and applied for thirty-one patents. Among the many honors he has received for his research achievements are two National Scientific and Technological Advancement Prizes. YIMING WANG is Professor at Tsinghua University. QIONGLIN LIANG is Associate Professor at Tsinghua University. QINGFEI LIU is Assistant Professor at Tsinghua University.

Inhaltsangabe

FOREWORD ix PREFACE xiii ABBREVIATIONS xvii 1 INTRODUCTION OF SYSTEMS
BIOLOGY IN TRADITIONAL CHINESE MEDICINE (TCM) 1 1.1 Characteristics and
Compatibility Principles of Traditional Chinese Medicine (TCM) 1 1.2 Key
Scientifi c Issues in TCM Modernization 9 1.3 Development of Systems
Biology 16 1.4 Chemomics Integrated Systems Biology 19 1.5 Research
Strategy and Prospective of Systems Biology in TCM 25 References 34 2
CHEMOMICS OF TRADITIONAL CHINESE MEDICINE 38 2.1 Characteristics and
Research Diffi culties in TCM 39 2.2 Background of TCM Chemomics' Proposal
and Development 45 2.3 Chemomics 52 2.4 Chemomics and the Research of
Formulas 58 References 63 3 TECHNOLOGICAL PLATFORM OF TCM CHEMOMICS 66 3.1
Acquisition Methods and Techniques for TCM Chemomics 66 3.2
Characterization Techniques of Chemome-TCM Fingerprinting 73 3.3
Information Processing for the Study of TCM Chemomics 107 3.4 Development
of an Intelligent Quality Control System in the Process of Chinese Medicine
Production 119 References 127 4 PHARMACOKINETIC INVESTIGATION ON TCM
FORMULAS BASED ON GLOBAL SYSTEMS BIOLOGY 131 4.1 Pharmacokinetic
Characteristics of TCM Formulas 131 4.2 Methodology of Pharmacokinetics of
TCM Formulas 133 4.3 Application of PK-PD Model in the Toxicological
Research of Liushen Pills (LSP) 138 4.4 Prospect 143 References 144 5
APPLICATION OF GENOMICS IN THE RESEARCH OF TCM 146 5.1 Genomics and TCM
System Research 146 5.2 Prospect of Genomics in TCM Research 148 5.3 Cases
of the Application of Genomics in TCM Research 148 References 168 6
PROTEOMICS STUDY OF TCM 171 6.1 Proteomics in TCM Research 171 6.2 A Case
Study of Proteomics in TCM 174 6.3 The Application of High Content
Screening in TCM Research 182 6.4 Limitations and Prospect of TCM
Proteomics 186 References 187 7 APPLICATION OF METABONOMICS IN RESEARCH ON
TCM 191 7.1 Current Research Situation of Metabonomics 191 7.2 Integration
of Quantitative Metabonomics Platform Technology (QMPT) 191 7.3 Application
of Metabonomics in the Field of Medicine 194 7.4 Examples of Metabonomic
Research on TCM 198 References 206 8 APPLICATION OF CHEMOMETRICS AND
BIOINFORMATICS IN TCM RESEARCH 210 8.1 Introduction of Chemometrics 210 8.2
Chemometric Techniques and Their Applications in TCM Research 211 8.3
Introduction of Bioinformatics 216 8.4 Bioinformatics Techniques and Their
Applications in the Research of TCM 219 8.5 Conclusions 222 References 224
9 STUDY OF INTEGRATED BIOMARKER SYSTEM OF DIABETIC NEPHROPATHY 228 9.1
Introduction of Diabetic Nephropathy 228 9.2 Mogensen Staging and TCM
Typing of DN 234 9.3 The Metabonomics Study of DN 244 9.4 Condition of
Metabolism after Treatment with TangShen Formula (TSF) 278 9.5 Genomics
Study of Diabetic Neuropathy 286 9.6 The Integrated Biomarker System of DN
301 9.7 Conclusions 311 References 312 10 CHEMOMICS RESEARCH ON THE TCM
FORMULA OF THE QINGKAILING INJECTION 317 10.1 Chemomics Research of
Qingkailing Injection 318 10.2 Pharmacodynamic Evaluation of Qingkailing
Injection 330 10.3 Research on the Qingkailing Derived Formula 335 10.4
Conclusions 368 References 369 11 INTEGRATED GLOBAL SYSTEMS BIOLOGY FOR THE
RESEARCH AND DEVELOPMENT OF CHINESE MEDICINE SHUANGLONG FORMULA 371 11.1
Brief Introduction to the Shuanglong Formula 371 11.2 Chemomics Study of
the Shuanglong Formula 374 11.3 Pharmacodynamic Evaluation of SLF Effective
Ingredients 384 11.4 Systems Biology Study of the Mechanism of Directed
Differentiation of Stem Cells Induced by NSLF6 402 11.5 Anti-Myocardial
Infarction Effect of NSLF6 426 11.6 Conclusions 429 References 430 12
DEMONSTRATIVE RESEARCH ON THE SAFETY EVALUATION OF LIUSHEN PILLS 437 12.1
Introduction 437 12.2 Toxicity Study of Chansu 438 12.3 Chemomics Study of
LSP 446 12.4 Assessment of Effectiveness and Safety of LSP 457 12.5 In Vivo
Distribution and Metabonomics of LSP and Xionghuang 462 12.6 Metabonomic
Research of LSP 467 12.7 Conclusions 477 References 478 INDEX 481