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This issue of Anesthesiology Clinics, edited by Dr. Karsten Bartels and Dr. Stefan Dieleman in collaboration with Consulting Editor Dr. Lee Fleisher, focuses on Cardiothoracic Anesthesia and Critical Care. Topics in this issue include: Anesthetic Management for Endovascular Repair of the Thoracic Aorta; Ethical Considerations for Mechanical Support; Modulating Perioperative Ventricular Excitability; Echocardiography Education for Anesthesia Trainees; Mitochondrial Dysfunction After Cardiac Surgery; New Approaches to Perioperative Right Ventricular Assessment; New Techniques for Optimization of Donor Lungs/Hearts; Recent Developments in Catheter-Based Cardiac Procedures; Heart Failure in Adults with Congential Heart Disease; Optimizing Perioperative Blood and Coagulation Management During Cardiac Surgery; Advances in the Prevention of AKI Following Cardiac Surgery; Clinical Trials That Should be Done in Cardiac Anesthesia; and Cardiac Surgery and the Blood-Brain Barrier.