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Could cannabinoids be antidepressant? chronic administration of the phytocannabinoids (THC, CBD) as well as rimonabant had no antidepressant-like effect in normal rats. However, chronic administration of THC and rimonabant had antidepressant-like effects in the OB-model of depression. Given the emergence of anxiety and depression in patients treated with rimonabant, this opens a debate about the predictive validity of animal models for drug effects in humans

Produktbeschreibung
Could cannabinoids be antidepressant? chronic administration of the phytocannabinoids (THC, CBD) as well as rimonabant had no antidepressant-like effect in normal rats. However, chronic administration of THC and rimonabant had antidepressant-like effects in the OB-model of depression. Given the emergence of anxiety and depression in patients treated with rimonabant, this opens a debate about the predictive validity of animal models for drug effects in humans
Autorenporträt
Personal data:Name : Maha ElBatshQualifications : MBBCh, MSc Clinical Pharmacology, PhD Neuropharmacology