Volkmar Weissig, Gerard G. D'Souza

Organelle-Specific Pharmaceutical Nanotechnology

• Gebundenes Buch

Produktbeschreibung

This book introduces and discusses the latest in biomedical research--Pharmaceutical Nanotechnology applied at the sub-cellular level.

Produktdetails

• Verlag: Wiley & Sons
• 1. Auflage
• Seitenzahl: 608
• Erscheinungstermin: 2. November 2010
• Englisch
• Abmessung: 236mm x 160mm x 38mm
• Gewicht: 1089g
• ISBN-13: 9780470631652
• ISBN-10: 0470631651
• Artikelnr.: 30628303

Autorenporträt

Volkmar Weissig, ScD, PhD, is Associate Professor of Pharmacology at Midwestern University in Glendale, Arizona. He has been actively pioneering mitochondrial pharmaceutics for the last decade. The holder of sixteen patents and author of more than eighty research papers, review articles, and book chapters, Dr. Weissig serves as Associate Editor of the Journal of Liposome Research and is the member of several other editorial boards. He is an active member of the International Liposome Society, the Mitochondria Research Society, the American Association of Pharmaceutical Scientists, and the American Association for the Advancement of Science. Gerard G.M. D'Souza, PhD, is Assistant Professor of Pharmaceutics at Massachusetts College of Pharmacy and Health Sciences in Boston. He has coauthored more than twenty peer-reviewed publications in the fields of pharmaceutical nanotechnology and mitochondrial pharmaceutics. Dr. D'Souza is a member of the editorial board for the Journal Drug Delivery and serves as a peer reviewer for several journals in the field of drug delivery.

Inhaltsangabe

Preface. Contributors. 1. An Introduction to Subcellular Nanomedicine:
Current Trends and Future Developments (Gerard G. M. D'Souza and Volkmar
Weissig). 2. Delivery of Nanonsensors to Measure the Intracellular
Environment (Paul G. Coupland and Jonathan W. Aylott). 3. Cytoplasmic Diffi
usion of Dendrimers and Dendriplexes (Alexander T. Florence and Pakatip
Ruenraroengsak). 4. Endocytosis and Intracellular Trafficking of Quantum
Dot-Ligand Bioconjugates (Tore-Geir Iversen, Nadine Frerker, and Kirsten
Sandvig). 5. Synthesis of Metal Nanoparticle-Based Intracellular Biosensors
and Therapeutic Agents (Neil Bricklebank). 6. Subcellular Fate of
Nanodelivery Systems (Dusica Maysinger, Sebastien Boridy, and Eliza
Hutter). 7. Intracellular Fate of Plasmid DNA Polyplexes (Kevin Maier and
Ernst Wagner). 8. Intracellular Trafficking of Membrane Receptor-Mediated
Uptake of Carbon Nanotubes (Bin Kang and Yaodong Dai). 9. Real-Time
Particle Tracking for Studying Intracellular Transport of Nanotherapeutics
(Clive Chen and Junghae Suh). 10. Tracking Intracellular Polymer
Localization Via Fluorescence Microscopy (Simon C. W. Richardson). 11. Can
QSAR Models Describing Small-Molecule Xenobiotics Give Useful Tips for
Predicting Uptake and Localization of Nanoparticles in Living Cells? And If
Not, Why Not? (Richard W. Horobin). 12. Self-Unpacking Gene Delivery
Scaffolds (Millicent O. Sullivan). 13. Cellular Trafficking of Dendrimers
(Yunus Emre Kurtoglu and Rangaramanujam M. Kannan). 14.
Endolysosomolytically Active pH-Sensitive Polymeric Nanotechnology (Han
Chang Kang and You Han Bae). 15. Uptake and Intracellular Dynamics of
Proteins Internalized by Cell-Penetrating Peptides (Arwyn T. Jones). 16.
Cargo Transport by Teams of Molecular Motors: Basic Mechanisms for
Intracellular Drug Delivery (Melanie J. I. Müller, Florian Berger, Stegan
Klumpp, and Reinhard Lipowsky). 17. The Potential of Photochemical
Internalization (PCI) for the Cytosolic Delivery of Nanomedicines (Kristian
Berg, Anette Weyergang, Anders Høgset, and Pål Kristian Selbo). 18.
Peptide-Based Nanocarriers for Intracellular Delivery of Biologically
Active Proteins (Seong Loong Lo and Shu Wang). 19. Organelle-Specific
Pharmaceutical Nanotechnology: Active Cellular Transport of Submicro- and
Nanoscale Particles (Galya Orr). 20. Subcellular Targeting of
Virus-Envelope-Coated Nanoparticles (Jia Wang, Mohammad F. Saeed, Andrey A.
Kolokoltsov, and Robert A. Davey). 21. Mitochondria-Targeted Pharmaceutical
Nanocarriers (Volkmar Weissig and Gerard G.M. D'Souza). 22.
Cell-Penetrating Peptides for Cytosolic Delivery of Biomacromolecules
(Camilla Foged, Xiaona Jing, and Hanne Moerck Nielsen). 23. Therapeutic
Nano-object Delivery to Subdomains of Cardiac Myocytes (Valeriy
Lukyanenko). 24. Design Parameters Modulating Intracellular Drug Delivery:
Anchoring to Specific Cellular Epitopes, Carrier Geometry, and Use of
Auxiliary Pharmacological Agents (Silvia Muro and Vladimir R. Muzykantov).
25. Uptake Pathways Dependent Intracellular Trafficking of DNA Carrying
Nanodelivery Systems (Ikramy A. Khalil, Yuma Yamada, Hidetaka Akita, and
Hideyoshi Harashima). 26. Cellular Interactions of Plasmon-Resonant Gold
Nanorods (Qingshan Wei and Alexander Wei). 27. Quantum Dot Labeling for
Assessment of Intracellular Trafficking of Therapeutically Active Molecules
(Diane J. Burgess and Mamta Kapoor). Index.