In Sunderland, England, a city quarantined by the cholera epidemic of 1831, Gustine, a defiant fifteen-year-old beauty in an elegant blue dress rented from her pimp-landlord, sells her body to feed her only love: a fragile baby boy. When she meets surgeon Henry Chiver, who has recently been implicated in a series of killings in which beggars were murdered so the corpses could be sold for medical research, Gustine begins working for him by securing cadavers for his ill-equipped anatomy school. It is a gruesome job that will soon threaten the very things she's working so hard to protect.