Featuring the work of pioneering investigators, including Nobel Laureate, Dr. Stanley Prusiner, this comprehensive volume begins with a study of the mechanisms of fibril formation and cellular response and discusses emerging diagnostic and translational approaches. It covers- * Possible horizontal transmission * Charge differences of deposits in AL and NALCDD * Novel assays to detect amyloid induced apoptosis * AA and localized amyloidosis * Hereditary gelsolin amyloidosis, and other novel mutations * ALBASE as a platform analysis tool * AL amyloidosis in the elderly * Naturally occurring antibodies as a potential therapy * Clinical trials of melphalan-dexamethasone * Autologous stem cell transplantation
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