David J. Balding, Christopher D. Steele

Weight-of-Evidence for Forensic DNA Profiles (eBook, PDF)

• Format: PDF

Produktbeschreibung

DNA evidence is widely used in the modern justice system. Statistical methodology plays a key role in ensuring that this evidence is collected, interpreted, analysed and presented correctly. This book is a guide to assessing DNA evidence and presenting that evidence in a courtroom setting. It offers practical guidance to forensic scientists with little dependence on mathematical ability, and provides the scientist with the understanding they require to apply the methods in their work. Since the publication of the first edition of this book in 2005 there have been many incremental changes, and one dramatic change which is the emergence of low template DNA (LTDNA) profiles. This second edition is edited and expanded to cover the basics of LTDNA technology. The author's own open-source R code likeLTD is described and used for worked examples in the book. Commercial and free software are also covered.

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Produktdetails

• Verlag: John Wiley & Sons
• Seitenzahl: 232
• Erscheinungstermin: 11. Mai 2015
• Englisch
• ISBN-13: 9781118814536
• Artikelnr.: 42885330

Autorenporträt

David J. Balding, University of Melbourne, Australia; and University College London, UK. Christopher D. Steele, University College London, UK.

Inhaltsangabe

Preface to the 2nd edition xvi Preface to the 1st edition xvii 1
Introduction 1 1.1 Weight-of-evidence theory 1 1.2 About the book 3 1.3 DNA
profiling technology 4 1.4 What you need to know already 5 1.5 Other
resources 6 2 Crime on an island 9 2.1 Warm-up examples 10 2.1.1 People v.
Collins (California, 1968) 10 2.1.2 Disease testing: Positive Predictive
Value (PPV) 10 2.1.3 Coloured taxis 12 2.2 Rare trait identification
evidence 14 2.2.1 The \island" problem 14 2.2.2 A first lesson from the
island problem 15 2.3 Making the island problem more realistic 17 2.3.1 The
effect of uncertainty about p 17 2.3.2 Uncertainty about N 19 2.3.3 The
effect of possible typing errors 19 2.3.4 The effect of searches 20 2.3.5
The effect of other evidence 22 2.3.6 The effects of relatives and
population subdivision 23 2.4 Weight-of-evidence exercises 24 3 Assessing
evidence using likelihoods 27 3.1 Likelihoods and their ratios 28 3.2 The
weight-of-evidence formula 29 3.2.1 Application to the island problem 31
3.3 General application of the formula 32 3.3.1 Several items of evidence
32 3.3.2 The role of the expert witness 34 3.4 Consequences for DNA
evidence 35 3.4.1 Many possible culprits 35 3.4.2 Incorporating the non-DNA
evidence 35 3.4.3 Relatives 38 3.4.4 Laboratory and handling errors 39
3.4.5 Database searches 40 3.5 Derivation of the weight-of-evidence formula
y 42 3.5.1 Bayes Theorem 42 3.5.2 Uncertainty about p and N 43 3.5.3
Grouping the alternative possible culprits 44 3.5.4 Typing errors 45 3.6
Further weight-of-evidence exercises 46 4 Profiling technologies 49 4.1 STR
typing 50 4.1.1 Anomalies 53 4.1.2 Contamination 56 4.1.3 Low-template DNA
(LTDNA) profiling 56 4.2 mtDNA typing 58 4.3 Y-chromosome markers 59 4.4
X-chromosome markers i 59 4.5 SNP profiles i 60 4.6 Sequencing i 62 4.7
Methylation i 62 4.8 RNA i 63 4.9 Fingerprints i 63 5 Some population
genetics for DNA evidence 65 5.1 A brief overview 65 5.1.1 Drift 65 5.1.2
Mutation 68 5.1.3 Migration 69 5.1.4 Selection 70 5.2 FST 71 5.2.1
Population genotype probabilities 73 5.3 A statistical model and sampling
formula 74 5.3.1 Diallelic loci 74 5.3.2 Multi-allelic loci 79 5.4
Hardy-Weinberg equilibrium 80 5.4.1 Testing for deviations from HWE i 81
5.4.2 Interpretation of test results 86 5.5 Linkage equilibrium 86 5.6
Coancestry i 88 5.7 Likelihood-based estimation of FST i 90 5.8 Population
genetics exercises 92 6 Inferences of identity 95 6.1 Choosing the
hypotheses 95 6.1.1 Post-data equivalence of hypotheses 97 6.2 Calculating
LRs 99 6.2.1 The match probability 99 6.2.2 Single locus 100 6.2.3 Multiple
loci: the \product rule" 103 6.2.4 Relatives of Q 105 6.2.5 Confidence
limits i 107 6.2.6 Other profiled individuals 108 6.3 Application to STR
profiles 109 6.3.1 Values for the pj 109 6.3.2 The value of FST 111 6.3.3
Choice of population 112 6.3.4 Errors 113 6.4 Application to haploid
profiles 114 6.4.1 mtDNA profiles 114 6.4.2 Y-chromosome markers 116 6.5
Mixtures 117 6.5.1 Visual interpretation of mixed profiles 117 6.5.2
Likelihood ratios under qualitative interpretation 119 6.5.3 Quantitative
interpretation of mixtures 124 6.6 Identification exercises 126 7 Inferring
relatedness 129 7.1 Paternity 129 7.1.1 Weight of evidence for paternity
129 7.1.2 Prior probabilities 130 7.1.3 Calculating LRs 131 7.1.4 Multiple
loci: the effect of linkage 136 7.1.5 Q may be related to c but not the
father 138 7.1.6 Incest 139 7.1.7 Mother unavailable 140 7.1.8 Mutation 141
7.2 Other relatedness between two individuals 146 7.2.1 Only the two
individuals profiled 146 7.2.2 Profiles of known relatives also available y
147 7.2.3 Software for relatedness analyses 148 7.3 Familial search 150 7.4
Inference of ethnicity y 151 7.5 Inference of phenotype y 153 7.6
Relatedness exercises 153 8 Low template DNA profiles 155 8.1 Background
155 8.2 Stochastic effects in LTDNA profiles 158 8.2.1 Dropout 158 8.2.2
Dropin 158 8.2.3 Peak Imbalance 159 8.2.4 Stutter 159 8.3 Computing
likelihoods 160 8.3.1 Single contributor allowing for dropout 160 8.3.2
Profiled contributors not subject to dropout 161 8.3.3 Modelling dropin 162
8.3.4 Multi-dose dropout and degradation 163 8.3.5 Additional contributors
subject to dropout 164 8.3.6 Replicates 164 8.3.7 Using peak heights 165
8.4 Quality of results 168 9 Introduction to likeLTDi 171 9.1 Installation
and example R script 172 9.1.1 Input 172 9.1.2 Allele report 173 9.1.3
Arguments and optimisation 173 9.1.4 Output report 175 9.1.5 Genotype
probabilities 177 9.2 Specifics of the package 179 9.2.1 The parameters 179
9.2.2 Key features of likeLTD 180 9.2.3 Maximising the penalised likelihood
181 9.2.4 Computing time and memory requirements 182 9.3 Verification 183
10 Other approaches to weight of evidence 187 10.1 Uniqueness 188 10.1.1
Analysis 189 10.1.2 Discussion 190 10.2 Inclusion/Exclusion probabilities
190 10.3 Hypothesis Testing y 193 10.4 Other exercises 194 11 Some issues
for the courtroom 197 11.1 The role of the expert witness 197 11.2 Bayesian
reasoning in court 198 11.3 Some fallacies 200 11.3.1 The prosecutor's
fallacy 200 11.3.2 The defendant's fallacy 201 11.3.3 The uniqueness
fallacy 201 11.4 Some UK appeal cases 202 11.4.1 Deen (1993) 202 11.4.2
Adams (1996) 202 11.4.3 Doheny/Adams (1996) 204 11.4.4 Watters (2000) 206
11.4.5 T (2010) 207 11.4.6 Dlugosz (2013) 209 11.5 US National Research
Council reports 210 11.6 Prosecutor's fallacy exercises 212 12 Solutions to
exercises 213