Using Eye Movements as an Experimental Probe of Brain Function (eBook, ePUB)

A Symposium in Honor of Jean Büttner-Ennever
Redaktion: Leigh, R. John; Kennard, Christopher

• Format: ePub

Produktbeschreibung

This volume of Progress in Brain Research is based on the proceedings of a conference, "Using Eye Movements as an Experimental Probe of Brain Function," held at the Charing Cross Hospital Campus of Imperial College London, UK on 5th -6th December, 2007 to honor Professor Jean Büttner-Ennever. With 87 contributions from international experts - both basic scientists and clinicians - the volume provides many examples of how eye movements can be used to address a broad range of research questions. Section 1 focuses on extraocular muscle, highlighting new concepts of proprioceptive control that involve even the cerebral cortex. Section 2 comprises structural, physiological, pharmacological, and computational aspects of brainstem mechanisms, and illustrates implications for disorders as diverse as opsoclonus, and congenital scoliosis with gaze palsy. Section 3 addresses how the cerebellum transforms neural signals into motor commands, and how disease of such mechanisms may lead to ataxia and disorders such as oculopalatal tremor. Section 4 deals with sensory-motor processing of visual, vestibular, somatosensory, and auditory inputs, such as are required for navigation, and gait. Section 5 illustrates how eye movements, used in conjunction with single-unit electrophysiology, functional imaging, transcranial magnetic stimulation, and lesion studies have illuminated cognitive processes, including memory, prediction, and even free will. Section 6 includes 18 papers dealing with disorders ranging from congenital to acquired forms of nystagmus, genetic and degenerative neurological disorders, and treatments for nystagmus and motion sickness.

* Clinicians will find important new information on the substrate for spinocerebellar ataxia, late-onset Tay-Sachs disease, Huntington disease, and pulvinar lesions
* Organizes multiple articles on such topics as proprioception, short and longer-term memory, and hereditary cerebellar ataxias for a more coherent presentation
* Articles on anatomic tracers, functional imaging, and computational neuroscience are illustrated in color

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Produktdetails

• Verlag: Elsevier Science & Techn.
• Seitenzahl: 652
• Erscheinungstermin: 2. September 2008
• Englisch
• ISBN-13: 9780080932323
• Artikelnr.: 38122160

Inhaltsangabe

Section 1: Using Novel Techniques to Define the Neural Substrate for Eye
Movements
Jean Büttner-Ennever, Munich: Re-mapping the oculomotor system
Joseph Demer, Los Angeles: Using high-definition MRI to re-define the
mechanics of eye rotations
Michael Goldberg, New York: The cortical representation of oculomotor
proprioception
David Zee, Baltimore: How new knowledge of the anatomy of the eye muscles
and their innervation translates into improved treatment of patients with
ocular motor palsies
Paul Knox, Liverpool: Testing the influences of extraocular proprioception
in humans
James Sharpe, Toronto: Reinterpreting palsies of the ocular motor nerves
Dominik Straumann: New insights into trochlear nerve palsy
Paul May: Anatomical insights into peripheral gaze control
Louis Dell'Osso: How disrupting ocular proprioception can be therapy for
congenital nsyatgmus
Section 2: New Insights into Brainstem Generation of Ocular Motor Commands
Anja Horn, Munich: New insights into the circuitry and pharmacology of the
brainstem reticular formation
Edward Keller, San Francisco: Using multiple electrode arrays to map moving
fields of neural activity in the superior colliculus
Paul Gamlin, Birmingham: Synthesis of vergence control by brainstem
circuits
Holger Rambold, Lübeck: Disturbances of vergence and saccadic eye movements
by human brainstem lesions
Christoph Helmchen, Luebeck: Understanding how the cerebellar disease could
cause saccadic oscillations
Stefano Ramat, Pavia: A brainstem network that accounts for abnormal
saccades
Mark Gibson, Belfast: Human saccadic disorders and their brainstem
mechanisms
Richard Clement: A black-box approach to saccadic disorders
Section 3: Using Eye Movements as an Index of Transformation of Signals by
the Cerebellum
Stephen Highstein, St. Louis: How the cerebellar transforms sensory inputs
into motor commands
Albert Fuchs, Seattle: How visual and motor signals interact in the
cerebellum
John Stahl, Cleveland: How mutant mice with calcium channel defects provide
insight into the cerebellar role in balance
Michael Strupp, Munich: How knowledge about calcium channel disorders
translates into treatment of human cerebellar disease
Bernard Cohen, New York: Cerebellar governance of vestibular mechanisms
Mark Walker, Baltimore: Influence of cerebellar nodulus on translational
vestibulo-ocular reflex
Ulrich Büttner, Munich: Control of smooth-pursuit eye movements by
cerebellum
Robert McCrea, Chicago: Influence of cerebellum on combined eye-head
tracking
Adolfo Bronstein, London: Degenerative disorders that affect the cerebellar
control of eye movements
Section 3: Using Eye Movements as a Probe of Sensory-Motor Processing
Frederick Miles, Bethesda: How the brain uses visual motion as we move
through the environment
Peter Hoffmann: How motion signals are encoded in visual areas
Michael Mustari, Atlanta: How disturbed maturation of visual motion
processing leads to nystagmus in infancy
Thomas Brandt: How vestibular and visual inputs may be abnormally processed
in cerebral cortex
Richard Abadi, Manchester: Visual perceptions during ocular oscillations
Michael Gresty, London: Self-motion, gaze control and visual perception
Bernhard Hess, Zurich: Understanding interactions between responses to head
rotations and translations
Michael Halmagyi, Sydney: Probing otolith-ocular reflexes using novel
stimuli in humans
Sergei Yakushin, New York: How visual inputs from subcortical pathways
influence perception of self-motion
Section 4: Using Eye Movements as a Probe of Cognition
James Lynch, Jackson: Concepts of the contribution of cerebral cortex based
on new anatomical findings
Kikuro Fukushima, Sapporo: Prediction, eye movements, and the frontal lobes
Rene Müri, Bern: Using transcranial magnetic stimulation to probe
decision-making and memory
Parashkev Nachev, London: Using functional imaging to during conflict
resolution and free choice
Charles Pierrot-Deseilligny, Paris: Using saccades to probe different forms
of memory
Christopher Kennard, London: Role of the supplementary eye fields in
countermanding saccades
Masud Husain, London: Using eye movements to probe shifts of instruction
set
Graham Barnes, Manchester: Using smooth tracking movements to probe
prediction
R. John Leigh, Cleveland, Ohio: Eye movements: The meaning of it all
(Epilogue)