The Respiratory Functions of Blood (eBook, PDF)

Redaktion: Garby, Lars

• Format: PDF

Produktbeschreibung

This monograph is the first of a series which is designed to present in depth timely reviews of subjects related to the blood. Insofar as each subject lends itself, the clinical aspects of each topic will be presented as fully as is appropriate, in addition to the basic features. As a consequence, the various monographs should be found useful not solely by hematologists. Depending on the nature of each topic, it is expected that these monographs will be found important by physiologists and specialists in fields other than hematology, as well as by scientists of very diverse interests. The present treatise illus trates this point. Doctors Garby and Meldon have brought together in a most useful way the spectacular advances which have been made in the last decade or two in a field of fundamental biologic impor tance. They have also brought to the discussion of this subject their own observations and interpretations as well as their profound understanding of the respiratory functions of the blood. Maxwell M. Wintrobe Salt Lake City, Utah v Preface This volume is an attempt to summarize the present state of know ledge of the respiratory functions of blood in health and disease. Though it deals fairly thoroughly with physicochemical aspects of the blood's gas transport properties and with the molecular chemis try of hemoglobin, its main emphasis is the gas transport function of the blood in vivo and modes of its disturbance in disease.

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Produktdetails

• Verlag: Springer New York
• Seitenzahl: 282
• Erscheinungstermin: 6. Dezember 2012
• Englisch
• ISBN-13: 9781468423136
• Artikelnr.: 43987731

Inhaltsangabe

1 Introduction.- 2 Two Gas Transport Problems.- Requirements at Rest.- Requirements during Exercise.- Some Further Requirements.- 3 Physical Relationships in Blood-Tissue Gas Transport.- 4 Blood as a Physicochemical System-I. Hemoglobin and Its Interaction with Ligands.- Hemoglobin Structure.- Ligand Binding and Conformational States.- Linked Functions.- The Molecular Basis of Ligand Binding, Conformational Change, and Allosteric Interaction of the Hemoglobin Molecule.- Oxygen Binding and Interaction Coefficients under Physiological Conditions.- Hemoglobin-Ligand Kinetics in Solution.- 5 Blood as a Physicochemical System-II. Equilibria, Steady States, and Transport Kinetics of the Red Cell-Plasma Distributions.- Definition of a Standard State for Measurements of Blood Composition.- The Standard Steady State Distributions.- Erythrocyte and Plasma Responses to Perturbations in Composition.- 6 The Dynamics of Oxygen, Carbon Dioxide, and Proton Transport under Normal Conditions.- The Model System.- Simulation of Gas Transport at Rest.- Oxygen Transport in Exercise.- Facilitated Gas Transport in Tissue.- 7 Some Physiological Control Systems.- The Controlled Gas Transport System.- The Red Cell 2,3-DPG Concentration.- The Whole Blood Hemoglobin Concentration.- Protection against Oxidation of Hemoglobin.- 8 Disturbances of the Respiratory Functions of Blood.- Abnormal Acid-Base Balance.- Abnormal Erythron function.- Abnormal Lung Function and Ambient Air.- 9 Concluding Remarks.- References.