Peter R. Bergethon

The Physical Basis of Biochemistry (eBook, PDF)

The Foundations of Molecular Biophysics

• Format: PDF

Produktbeschreibung

The Physical Basis of Biochemistry is an introduction to the philosophy and practice of an interdisciplinary field in which biological systems are explored using the quantitative perspective of the physical scientist. As with the first edition, the idea that a fundamental understanding of the basic physical principles underlying chemical biological systems is vital remains the focus of this second edition. This new edition of The Physical Basis of Biochemistry has substantial new material added with respect to models at the simple molecular level (including van der Waals gases and virial treatments) which is tied to coverage of models of polymer thermo-dynamics. The second edition is partitioned into five sections: the central concept that science is a way of looking at the world; the physical under-pinnings of biophysical chemistry with an emphasis first on energy, work and forces of biological importance; exploring how models applicable to molecular biophysics are constructed; the three-dimensional potential energy surface put into motion; and a succinct discussion of the bio-physical methods used to evaluate structure and function in biological systems. Additionally, a section of appendices continues to serve the pur¬pose of presenting some review information and certain topics in detail. The Physical Basis of Biochemistry will be of interest to quantitatively-oriented biologists as well as aspiring chemists, physicists, and engineers with an interest in biological systems.

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Produktdetails

• Verlag: Springer-Verlag GmbH
• Seitenzahl: 949
• Erscheinungstermin: 10. September 2010
• Englisch
• ISBN-13: 9781441963246
• Artikelnr.: 43785578

Autorenporträt

Kevin Hallock, Ph.D., is a researcher and instructor in the Department of Anatomy and Neurobiology at the Boston University School of Medicine in Boston, Masschusetts, where he teaches biostatistics, an graduate course on the science of disasters, and co-teaches biophysical chemistry and modeling courses with Dr. Bergethon. His research interests include the impact of antimicrobial peptide on phospholipid bilayers, solid-state NMR and magnetic resonance imaging characterization of crystalline solids, atherosclerotic plaque formation, magnetic resonance microscopy of arthropods, the impact of chronic Hg exposure on aging, and the role cell membrane biophysics play in the fundamental processes of neurophysics. Peter Bergethon, MD is the Head of the Neuroscience Interdisciplinary Modeling and Simulation Center (NIMS Center), the Laboratory for Intelligence Modeling and Neurophysics and a member of the faculty in both the Departments of Anatomy/Neurobiology and Biochemistry at Boston University School of Medicine. His research spirals around a core question: "What is the physical and systemic basis for creativity and intelligent behavior and how could such behavior be practically constructed or reconstructed?" Dr. Bergethon is also an active member of the American Academy of Neurology from which he received the Founder's Award , the Electrochemical, Biophysical, American Chemical Societies, the Society for Neuroscience and the American Society of Biochemistry and Cellular Biology.

Inhaltsangabe

PREFACEPART I: Principles of Biophysical InquiryChapter 1Introduction: "To the Student"Chapter 2Philosophy and Practice of Biophysical StudyChapter 3Overview of the Biological System Under Study - Descriptive ModelsChapter 4Physical Thoughts, Biological Systems - The application of modeling principles to understanding biological systemsChapter 5Probability and StatisticsPART II: FoundationsChapter 6Physical Principles: Energy - The Prime ObservableChapter 7Biophysical Forces in Molecular SystemsChapter 8An Introduction to Quantum MechanicsChapter 9Chemical PrinciplesChapter 10Measuring the Energy of a System: Energetics and the First Law of ThermodynamicsChapter 11Entropy and the Second Law of ThermodynamicsChapter 12Which Way Did That System Go? The Gibbs Free EnergyChapter 13The Thermodynamics of Phase EquilibriaPART III: Building a Model of Biomolecular StructureChapter 14Water: A Unique Structure, A Unique SolventChapter 15Ion-Solvent InteractionsChapter 16Ion-Ion InteractionsChapter 17Lipids in Aqueous SolutionChapter 18Macromolecules in SolutionChapter 19Molecular Modeling - Mapping Biochemical State SpaceChapter 20The Electrified InterphasePART IV: Function and Action Biological State SpaceChapter 21Transport and Kinetics: Processes Not at EquilibriumChapter 22Flow in a Chemical Potential Field: DiffusionChapter 23Flow in an Electrical Field: ConductionChapter 24Forces Across MembranesChapter 25Kinetics - Chemical KineticsChapter 26Bioelectrochemistry - Charge Transfer in Biological SystemsPART V: Methods for the Measuring Structure and FunctionChapter 27Separation and Characterization of Biomolecules Based on Macroscopic Properties (with Kristin E. Bergethon)Chapter 28Determining Structure by molecular interactions with photons: Electronic Spectroscopy (with Kristin Bergethon)Chapter 29Determining Structure by molecular interactions with photons: ScatteringPhenomenaChapter 30Analysis of Structure - MicroscopyChapter 31EpilogueChapter 32Physical ConstantsPART VI: APPENDICESAppendix AReview of Mathematical MethodsAppendix BQuantum ElectrodynamicsAppendix CThe Pre-Socratic Roots of Modern ScienceAppendix DThe Poisson FunctionAppendix EAssumptions of a Kinetic Theory of Ideal Gas BehaviorAppendix FDetermination of a Field from the PotentialAppendix GGeometric OpticsAppendix HThe Compton EffectAppendix IHamilton's Principle of Least Action/Fermat's Principle of Least TimeAppendix JEnergy of Interaction between ionsAppendix KDerivation of the Statement, Qrev > QirrevAppendix LDerivation of the Clausius-Clapeyron EquationAppendix MDerivation of the van't Hoff Equation for Osmotic PressureAppendix NPseudoforcesAppendix OWork of charging and discharging a rigid sphereAppendix PReview of Electrical CircuitsAppendix QFermi's Golden RuleAppendix RAdiabatic vs non-Adiabatic processes