The Pharmacology of Monoclonal Antibodies (eBook, PDF)

Redaktion: Rosenberg, Martin; Moore, Gordon P.

• Format: PDF

Produktbeschreibung

A sample of the most exciting developments in the cloning, manipulation, expression and application of genetically-engineered monoclonal antibodies. This rapidly-evolving field has witnessed the PCR combinatorial cloning of vast immunological diversity, in vitro mutagenesis of MAbs, MAbs created by transgenic animals, novel expression systems in plants, animals and lower systems, as well as a rich variety of genetically modified MAbs as potential therapeutic agents. Leading scientists from academia and industry present their own findings as well as short reviews of these research areas.

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Produktdetails

• Verlag: Springer Berlin Heidelberg
• Seitenzahl: 406
• Erscheinungstermin: 6. Dezember 2012
• Englisch
• ISBN-13: 9783642784323
• Artikelnr.: 53091245

Inhaltsangabe

Section I: Human Monoclonal Antibodies.- 1 Human Monoclonal Antibody Technology.- 2 Recombinant Therapeutic Human Monoclonal Antibodies.- 3 Transgenic Approaches to Human Monoclonal Antibodies.- Section II: Genetically Engineered Monoclonal Antibodies.- 4 Humanization of Monoclonal Antibodies.- 5 Applications for Escherichia coli-Derived Humanized Fab' Fragments: Efficient Construction of Bispecific Antibodies.- Section III: MAb Conjugates and Fusions.- 6 Immunotoxins.- 7 Antibody-Enzyme Fusion Proteins and Bispecific Antibodies.- 8 Three Generations of Recombinant CD4 Molecules as Anti-HIV Reagents.- Section IV: Combinatorial Libraries.- 9 Chemical and Biological Approaches to Catalytic Antibodies.- 10 The Combinatorial Approach to Human Antibodies.- Section V: Expression of MAbs/MAb Fragments.- 11 Antibodies from Escherichia coli.- 12 Structure, Function and Uses of Antibodies from Transgenic Plants and Animals.- 13 Some Aspects of Monoclonal Antibody Production.- Section VI: Medical Applications.- 14 Prospects for Cancer Imaging and Therapy with Radioimmunoconjugates.- 15 Clinical Experience with Murine, Human and Genetically Engineered Monoclonal Antibodies.- 16 Anti-idiotypic Monoclonal Antibodies: Novel Approach to Immunotherapy.