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Angiogenesis, the development of new blood vessels from an existing vascular bed, is an essential feature in many pathological conditions, including cancer, atherosclerosis, rheumatoid arthritis, and diabetic neuropathy. Inadequate regulation of angiogenesis can often lead to chronic pressure ulcers, duodenal ulcers, and myocardial infarction. In The New Angiotherapy, an international team of experts critically review the recent progress in both basic and applied research on angiogenesis. Their cutting-edge discussion ranges from the stimulation and repression of angiogenesis to the discovery of novel angiotherapeutic targets and their use in the clinic. Details of fundamental concepts in angiogenesis physiology and pathophysiology are provided, and the potential of angiotherapy in the management of angiogenic disease is evaluated, highlighting some of the angiogenic and antiangiogenic agents both in development and in clinical trials. The future prospects of receptor antagonists, enzyme inhibitors, and vascular targeted approaches, especially gene therapy in the development of angiotherapy, are also covered. Authoritative and cutting-edge, The New Angiotherapy illuminates our understanding of the central role of human angiogenesis, as well as the novel therapeutic approaches now made possible by our ability to control vascular development.
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From the Foreword by Judah Folkman, "In this very timely and informative book, Tai Ping Fan and Elise Kohn have assembled chapters authored by many of the leading scientists in the field of angiogenesis research. The molecular underpinnings of the angiogenic process in reproduction, development, repair and in disease, are clearly developed. Broad coverage is given to preclinical and clinical applications of angiogenesis inhibitors, and the book is a valuable source of references to the many aspects of the angiogenic process. . .The importance of quantifying effectiveness of antiangiogenic therapy is just one of many new directions in angiogenesis research both basic and clinical, which are highlighted by the authors. Future directions are also emphasized in the chapters on gene therapy, therapeutic angiogenesis for ischemic disease of the heart and limbs, and in new thinking about preventive antiangiogenic therapy." -Judah Folkman, July 2001 "This is an excellent collection of reviews in the field of angiogenesis therapy. This is an important area because growth factors are now in the clinical trials in the cardiovascular arena in an attempt to grow new vessels for ischemic disease. At the same time, antiangiogenesis is being evaluated to prevent tumor growth and neovascularization in the diabetic retina. Each chapter is well referenced and the index is very helpful in locating specific points in the book. This is an important addition to the medical literature. "-Doody's Health Sciences Book Review Journal, 96 score, 4 stars! "Fan and Kohn have assembled a group of international experts who have written up-to-date and detailed chapters on all aspects of the processes. The term 'therapeutic angiogenesis' encompasses the use of angiogenesis stimulation to overcome certain disease states. The material is quite detailed and aimed at investigators, but the book as a whole is an excellent reference for anyone interested in the field." - Oncology