M. Lynn Lamoreux, Véronique Delmas, Lionel Larue, Dorothy Bennett

The Colors of Mice (eBook, PDF)

A Model Genetic Network

• Format: PDF

Produktbeschreibung

Serving the needs of pigment cell biologists, cellular physiologists, developmental geneticists, researchers interested in melanoma and more, this new book showcases a blend of new technologies and new insights in the field of pigmantary genetics of mice, with comparative information on other animals. Graduate students can learn here the terminology and scope of the field, and animal fanciers can discover the genetics behind common color variants of mammals. The book is hailed for being written by four of the premier scientists in the field. These authors aim to present the molecular /cellular work in the context of phenotype and the interacting functions of genes that direct the development and function of one biological system. For other researchers, the depth of genetic knowledge on the pigmantary system makes it a valuable model for the study of other systems.

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Produktdetails

• Verlag: John Wiley & Sons
• Seitenzahl: 312
• Erscheinungstermin: 22. Februar 2010
• Englisch
• ISBN-13: 9781444319668
• Artikelnr.: 37344287

Autorenporträt

Associated with our Pigment Cell Journal, the authors are of the highest stature in their fields. Lynn Lamoreux is a mouse geneticist well known for her work in pigment system. Dorothy Bennett is an expert on growth and biology of melanocytes while Dr. Larue is an expert on melanoma. together they are some of the most respected researchers in pigment cell biology

Inhaltsangabe

Preface. Acknowledgments. Statement regarding the use of pictures.
Statement regarding nomenclature. Part I: Introduction to the Pigmentary
System. 1. Introduction to the Pigmentary System. 1.1. Introduction. 1.2.
Colors of vertebrate animals. 1.3. Other pigment cells. 1.4. The epidermal
melanin unit. 1.5. Mammalian hair. 1.6. Melanosome biogenesis and
translocation. 1.7. Melanin. 1.8. Hair growth. 1.9. Hair growth cycles.
1.10. Embryonic development of the pigment cell lineage. 1.11. Pigment
cells in culture. 1.12. Conclusion. Appendix: color loci of the mouse. Part
II: The Pigmentary Loci. 2. Introduction to Mutant Pigmentary Genes. 2.1.
Defects of normal melanocyte development: white spotting and graying with
age. 2.2. Defects in normal melanosome development: albinism. 2.3.
Transport of melanosomes to other cells: the 'dilute' phenotype. 2.4.
Pigment-type switching: from eumelanogenesis to pheomelanogenesis. 3. White
Spotting and Progressive Graying. 3.1. Definitions and general background .
3.2. Pigment cell development: developmental biology. 3.3. Cellular
signaling pathways for melanocytes. 3.4. Pigment phenotypes and the
classical white-spotting genes. 3.5. The head, heart, ears, and eyes. 4.
'Albinism' and the Failure of Normal Melanosome Development. 4.1.
Background. 4.2. The melanosomal matrix. 4.3. The enzymes that catalyze
melanogenesis. 4.4. Membrane proteins that regulate the internal milieu of
the melanosome. 4.5. Protein processing and routing to the maturing
melanosome. 4.6. Melanosome transport. 5. Pigment-Type Switching. 5.1.
Introduction. 5.2. Yellow phenotypes. 5.3. Melanin pigment . 5.4.
Melanogenesis and the eumelanin/pheomelanin switch mechanism. 5.5.
Signaling the switch mechanism at the cellular level. 5.6. Yellow genes.
Part III: Technology and Resources. 6. Novel Mouse Pigmentary Mutants
Generated by Genetic Manipulation. 6.1. Introduction. 6.2. Mouse
transgenesis: generation of genetically engineered mice. 6.3. Coat-color
transgenic mice. 6.4. The coat-color mutants generated by gene targeting.
6.5. Influence of the genetic background. 6.6. Conclusions. 7. Other
Species and Other Resources. 7.1. Introduction. 7.2. Resources. 7.3. Other
species. References. Index.