Gunter Mayer

The Chemical Biology of Nucleic Acids (eBook, ePUB)

• Format: ePub

Produktbeschreibung

With extensive coverage of synthesis techniques and applications, this text describes chemical biology techniques which have gained significant impetus during the last five years. It focuses on the methods for obtaining modified and native nucleic acids, and their biological applications. Topics covered include: * chemical synthesis of modified RNA * expansion of the genetic alphabet in nucleic acids by creating new base pairs * chemical biology of DNA replication: probing DNA polymerase selectivity mechanisms with modified nucleotides * nucleic-acid-templated chemistry * chemical biology of peptide nucleic acids (PNA) * the interactions of small molecules with DNA and RNA * the architectural modules of folded RNAs * genesis and biological applications of locked nucleic acid (LNA) * small non-coding RNA in bacteria * microRNA-guided gene silencing * nucleic acids based therapies * innate immune recognition of nucleic acid * light-responsive nucleic acids for the spatiotemporal control of biological processes * DNA methylation * frameworks for programming RNA devices * RNA as a catalyst: The Diels-Alderase-Ribozyme * evolving an understanding of RNA function by in vitro approaches * the chemical biology of aptamers: synthesis and applications * nucleic acids as detection tools * bacterial riboswitch discovery and analysis The Chemical Biology of Nucleic Acids is an essential compendium of the synthesis of nucleic acids and their biological applications for bioorganic chemists, chemical biologists, medicinal chemists, cell biologists, and molecular biologists.

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Produktdetails

• Verlag: John Wiley & Sons
• Seitenzahl: 478
• Erscheinungstermin: 20. Juni 2011
• Englisch
• ISBN-13: 9781119957263
• Artikelnr.: 37353943

Autorenporträt

Günter Mayer, Assistant Professor, LIMES Prog. Unit Chemical Biology and Medicinal Chemistry, Kekulé-Institute for Organic Chemistry and Biochemistry, University of Bonn, Germany Professor Mayer's research involves molecular diversity applied to elucidate the conformation, function and identity of biomolecules. He is a co-founder of NascaCell Technologies AG, a leading service provider of innovative biomolecules, where he headed the combinatorial biotechnology department. He has published papers in leading journals such as Nature, Angewandte Chemie and Journal of the American Chemical Society.

Inhaltsangabe

Foreword. Preface. List of Contributors. 1 Chemical Synthesis of Modified
RNA (Claudia Hobartner and Falk Wachowius). 2 Expansion of the Genetic
Alphabet in Nucleic Acids by Creating New Base Pairs (Ichiro Hirao and
Michiko Kimoto). 3 Chemical Biology of DNA Replication: Probing DNA
Polymerase Selectivity Mechanisms with Modified Nucleotides (Andreas Marx).
4 Nucleic Acid-templated Chemistry (Michael Oberhuber). 5 Chemical Biology
of Peptide Nucleic Acids (PNAs) (Peter E. Nielsen). 6 The Interactions of
Small Molecules with DNA and RNA (Yun Xie, Victor K. Tam and Yitzhak Tor).
7 The Architectural Motifs of Folded RNAs (Valerie Fritsch and Eric
Westhof). 8 Genesis and Biological Applications of Locked Nucleic Acids
(LNAs) (Harleen Kaur and Souvik Maiti). 9 Small Non-coding RNA in Bacteria
(Sabine Brantl). 10 MicroRNA-guided Gene Silencing (Gunter Meister). 11
Nucleic Acid-based Therapies (Britta Hoehn and John J. Rossi). 12 Innate
Immune Recognition of Nucleic Acids (Stefan Bauer). 13 Light-responsive
Nucleic Acids for the Spatiotemporal Control of Biological Processes
(Alexander Heckel and Gunter Mayer). 14 DNA Methylation (Albert Jeltsch and
Renata Z. Jurkowska). 15 Frameworks for Programming RNA Devices (Maung Nyan
Win, Joe C. Liang and Christina D. Smolke). 16 RNA as a Catalyst: The
Diels-Alderase Ribozyme (Andres Jaschke). 17 Evolving an Understanding of
RNA Function by In Vitro Approaches (Qing Wang and Peter J. Unrau). 18 The
Chemical Biology of Aptamers: Synthesis and Applications (Gunter Mayer and
Bernhard Wulffen). 19 Nucleic Acids as Detection Tools (Jeffrey C.F. Lam,
Sergio Aguirre and Yingfu Li). 20 Bacterial Riboswitch Discovery and
Analysis (Tyler D. Ames and Ronald R. Breaker). Index.