Navjeet Kaur

Synthesis of Aziridines and Oxaziridines from Imines (eBook, ePUB)

• Format: ePub

Produktbeschreibung

The smallest possible saturated azaheterocycle, aziridine, is well-known to organic chemists for its tremendous potential in pharmaceutical chemistry and organic synthesis. The general biological importance of aziridines is proven by the fact that they found several uses as subunits in pharmacologically active compounds such as antitumor agents, enzyme inhibitors, and antibiotics. Although aziridines are highly reactive, this framework occurs in many synthetic compounds and the natural products of biological interest also contain aziridine skeleton in their structures.

The synthetic community is captivated with prospects of selective synthesis and conversions of aziridines. Several important advances in this area have been witnessed in recent years and discovering efficient novel methods for the synthesis of aziridines has been very active field of research. Its powerful synthetic utility has been described by an overpowering amount of documentation on the approaches for the formation of aziridine.

Synthesis of Aziridines and Oxaziridines from Imines describes the new and old methods for the synthesis of aziridines from imines and covers an important and rapidly growing branch of heterocyclic chemistry. Readers will have access to different methods and information allowing them to evaluate which method is most suitable for particular cases.

• Focuses on the biological importance of different heterocycles
• Describes traditional and innovative methods for the synthesis of aziridines from imines
• Includes comparison amongst different methods, reagents, reaction conditions in tabulated forms, advantages, disadvantages, and critical analysis of different methodologies with respect to their comparison with green technique

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Produktdetails

• Verlag: Elsevier Science & Techn.
• Seitenzahl: 300
• Erscheinungstermin: 13. Januar 2024
• Englisch
• ISBN-13: 9780443220609
• Artikelnr.: 69786128

Autorenporträt

Dr. Navjeet Kaur received her BSc from Panjab University Chandigarh (Panjab, India) in 2008. In 2010, she completed her MSc in Chemistry from Banasthali Vidyapith. She was awarded with PhD in 2014 by the same university. With 11 years of teaching experience, she has published over 160 scientific research papers, review articles, book chapters, and monographs in the field of organic synthesis in national and international reputed journals. She has published five authored books: with Elsevier. She secured her place amongst top 2% scientists of the world in 2017 (single year ranking), 2018 (full career wise ranking), 2019 [full career wise ranking with 424 world rank (04 in India) and single year ranking with 03 world rank (01 in India)] and 2020 (full career wise ranking with 372 world rank and single year ranking with 126 world rank). In 2021, Dr. Kaur was chosen as a candidate for membership by Royal Society of Research, London, England, UK with full waiver of application fees. She is serving as an Editor-in-Chief of the "Advanced Chemicobiology Research¿ journal.

Inhaltsangabe

1. Aziridine synthesis from imines-I 2. Aziridine synthesis from imines-II
3. Aziridine synthesis by condensation of phenylimines with ethyl
diazoacetate 4. Aziridine synthesis by metal-catalyzed condensation of
phenylimines with ethyl diazoacetate 5. Aziridine synthesis by addition of
biphenyl imines to ethyl diazoacetate 6. Aziridine synthesis by
metal-catalyzed addition of biphenyl imines to ethyl diazoacetate 7.
Aziridine synthesis by condensation of imines with diazo compounds 8.
Aziridine synthesis by condensation of imines with diazomethane 9.
Aziridine synthesis by ring-closure of haloimines 10. Aziridine synthesis
by ring-closure of imines and halo compounds 11. Aziridine synthesis by
alkene-imine and alkyne-imine reactions 12. Oxaziridine synthesis from
imines 13. Oxaziridine synthesis from imines using m-CPBA