RNA Interference (eBook, PDF)

Application to Drug Discovery and Challenges to Pharmaceutical Development
Redaktion: Johnson, Paul H.

• Format: PDF

Produktbeschreibung

RNA Interference: Application to Drug Discovery and Challenges to Pharmaceutical Development provides a general overview of this rapidly emerging field, with a strong emphasis on issues and aspects that are important to a drug development team. The first part covers more general background of RNA interference and its application in drug discovery. In the second part, the book addresses siRNA (small interfering RNA), a pharmaceutically potent form, and its use and delivery in therapeutics along with manufacturing and delivery aspects.

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Produktdetails

• Verlag: John Wiley & Sons
• Seitenzahl: 336
• Erscheinungstermin: 14. Dezember 2010
• Englisch
• ISBN-13: 9780470923726
• Artikelnr.: 37300337

Autorenporträt

PAUL H. JOHNSON, PhD, is a cofounder and Chief Scientific Officer at PhaseRx, Inc. He is the author of numerous scientific papers and patents, and was the recipient of the 2007 Jeffrey Wenig Memorial Award for Outstanding Achievement in Drug Delivery.

Inhaltsangabe

CONTRIBUTORS. PREFACE. FOREWORD. I. Biology of RNA Interference. 1 RNA
Interference: What is it? (James A. Birchler). 2 Nucleic Acids as
Regulatory Molecules (Faqing Huang, C. J. Yu, and Yanlin Guo). 3 Use of
siRNA Oligonucleotides to Study Gene Function (Kristin A. Wiederholt and
Adam N. Harris). 4 Genome Scanning by RNA Interference (Roderick L.
Beijersbergen and Oliver C. Steinbach). II Development of siRNA for
Therapeutic Applications. 5 Discovery of New siRNA Delivery Agents (Paul H.
Johnson, Diane Frank, Kunyuan Cui, Roger Adami, Harry Wang, Michael
Houston, and Steven C. Quay). 6 siRNA Delivery Vehicles (Aliasger K. Salem
and Mark A. Behlke). 7 Interferon, Cytokine Induction and Other Potential
In Vivo Toxicities (Adam Judge, Marjorie Robbins, and Ian MacLachlan). 8
Application of RNA Interference to Viral Diseases (Ralph A. Tripp and
Stephen Mark Tompkins). Index.