Robert A. O'Brien

Receptor Binding in Drug Research (eBook, PDF)

• Format: PDF

Produktbeschreibung

This book describes the applications of receptor techniques in many different areas in addition to conventional drug and neurotransmitter binding sites. It reviews humoral modulators such as a leukotrienes, interferon, platelet-derived growth factor, and novel endogenous ligands.

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Produktdetails

• Verlag: Taylor & Francis
• Seitenzahl: 544
• Erscheinungstermin: 26. August 2020
• Englisch
• ISBN-13: 9781000103342
• Artikelnr.: 59975175

Autorenporträt

Robert A. O'Brien (Author)

Inhaltsangabe

Part I: Analysis and Interpretation of Receptor Screening Data 1. Receptor
Binding Methodology and Analysis 2. Computer Analysis of Binding Data James
Part II: Receptor Screening Applied to Specific Therapeutic Areas 3.
Benzodiazepines and Nonbenzodiazepines 4. Enhancers of Benzodiazepine
Binding 5. Convulsant and Anticonvulsant Drug Receptor Binding 6.
Neuroleptic Receptor Binding in Drug Research 7. Receptor Binding and
Atypical Antidepressant Drug Discovery 8. Central Recognition Sites for
Psychomotor Stimulants: Methylphenidate and Amphetamine 9. Opiate Receptor
Binding in Drug Research Part III: Receptor Interactions with Implications
in Multiple Therapeutic Areas 10. Molecular Heterogeneity of Leukotriene
Receptors 11. Purinergic Receptors in Mammalian Tissue 12. New Routine
Methodology to Study Steroid Hormone Binding Sites in Heterogeneous Tissues
13. pplication of Ligand Binding to the Development of New Calcium
Antagonists and Activators 14. Muscarinic Cholinergic Receptor Binding Part
IV: Receptor Applications to Peptides, Growth Factors, and Endogenous
Ligands 15. Interferon Receptors: Progress and Prospects 16. The
Platelet-Derived Growth Factor Receptor 17. Receptor Screening Assays for
Insulin and Other Growth Factors 18. Cholecystokinin Receptor Binding: Its
Use in Drug Research and Development 19. Using Radioreceptor Binding Assays
to Identify Endogenous Ligands Part V: In Vivo and In Vitro Receptor
Methodologies for Use in Drug Discovery and Characterization 20. In Vivo
Receptor Modifications as a Measure of Antidepressant Potential 21.
Antidepressant Interactions with Neurotransmitter Receptors in Vitro:
Prediction of Potential Side Effects 22. Altered Responsiveness of the
Noradrenergic-Coupled Adenylate Cyclase System in Brain 23. Quantitative
Autoradiography in Drug Research: Tricyclic Antidepressants 24.
Characterization of Agonist and Antagonist Interactions at the
Benzodiazepine Receptor 25. Receptor Binding Assays for Muscarinic
Cholinergic Agonists