Alexei V. Finkelstein, Oleg Ptitsyn

Protein Physics (eBook, ePUB)

A Course of Lectures

• Format: ePub

Produktbeschreibung

Protein Physics: A Course of Lectures covers the most general problems of protein structure, folding and function. It describes key experimental facts and introduces concepts and theories, dealing with fibrous, membrane, and water-soluble globular proteins, in both their native and denatured states.

The book systematically summarizes and presents the results of several decades of worldwide fundamental research on protein physics, structure, and folding, describing many physical models that help readers make estimates and predictions of physical processes that occur in proteins.

New to this revised edition is the inclusion of novel information on amyloid aggregation, natively disordered proteins, protein folding in vivo, protein motors, misfolding, chameleon proteins, advances in protein engineering & design, and advances in the modeling of protein folding.

Further, the book provides problems with solutions, many new and updated references, and physical and mathematical appendices. In addition, new figures (including stereo drawings, with a special appendix showing how to use them) are added, making this an ideal resource for graduate and advanced undergraduate students and researchers in academia in the fields of biophysics, physics, biochemistry, biologists, biotechnology, and chemistry.

• Fully revised and expanded new edition based on the latest research developments in protein physics
• Written by the world's top expert in the field
• Deals with fibrous, membrane, and water-soluble globular proteins, in both their native and denatured states
• Summarizes, in a systematic form, the results of several decades of worldwide fundamental research on protein physics and their structure and folding
• Examines experimental data on protein structure in the post-genome era

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Produktdetails

• Verlag: Elsevier Science & Techn.
• Seitenzahl: 528
• Erscheinungstermin: 22. Juni 2016
• Englisch
• ISBN-13: 9780081012369
• Artikelnr.: 45353862

Autorenporträt

Alexei V. Finkelstein is the Head of the Laboratory of Protein Physics at the Institute of Protein Research, Russian Academy of Sciences. He is also a Full Professor in Biophysics at the Pushchino Department of the Lomonosov Moscow State University. He won the National Prize of Russia in Science in 1999 and is a Howard Hughes Medical Institute International Research Scholar. He is the author of about 150 papers on protein physics.Oleg B. Ptitsyn (deceased 1999) was the Head of Protein Physics Laboratory at the Institute of Protein Research, Russian Academy of Sciences and a Visiting Scientist at the Laboratory of Experimental and Computational Biology, Molecular Structure Section, National Cancer Institute, USA. He was also a member of the European Academy of Sciences and winner of the National Prize of Russia in Science (1999). He authored about 250 papers on polymer and protein physics.Their laboratory is one of the most distinguished in the world for its work in protein physics. It is one of the few laboratories outside the USA to receive support from the Howard Hughes Medical Institute. Both scientists have very high international reputations, Professor Finkelstein is frequently invited to conferences in Europe and in the USA, as was Professor Ptitsyn before his recent death.

Inhaltsangabe

Elementary Interactions in Proteins and Around
Secondary Structures of Polypeptide Chains
Protein Structures
Cooperative Transitions in Protein Molecules
Protein Structure Prediction and Design
Protein Functions

Rezensionen

"It is not always easy to translate a good lecture course into an equally engaging textbook, but Finkelstein and Ptitsyn have succeeded in this difficult task. The twenty-five chapters are not only an accurate and detailed introduction to the physics of proteins, but also remarkably lively. ...the book is a pleasure to read and is well suited both as a textbook used in a course on protein science and as a tool for self-study." --Ulrich H. E. Hansmann for the BULLETIN OF MATHEMATICAL BIOLOGY, Sept. 2003

"The lectures are unique... anticipating questions from the students, and answering them, with an interspersion of simple examples...a good introduction to protein physics for students, ...will help chemists, physicists, and biologists acquire a widespread knowledge of current issues in protein structure, properties, and reactions." --Harold A. Scheraga, Todd Professor of Chemistry, Cornell University, USA

"Protein Physics provides all the essential information. ...concise, reliable and very well written" --Israel M. Gelfand, Distinguished Professor Rutgers University, USA

"Rigorous and thorough analysis of physical basis of protein structure...unique in its profound professionalism ... free, colloquial style." --Alexander S. Spirin, Professor of Biochemistry, Moscow University, Russia