Principles of Molecular Rheumatology (eBook, PDF)

Redaktion: Tsokos, George C.

• Format: PDF

Produktbeschreibung

Rheumatic diseases are complex in nature and require for their optimal diagnosis and treatment a critical understanding of the mechanisms that lead to their tissue pathology and various clinical manifestations. In Principles of Molecular Rheumatology, George Tsokos and a panel of authoritative clinicians and researchers synthesize all the latest findings from across cell and molecular biology with the basic principles of rheumatology to create the first textbook of molecular rheumatology. These established experts describe the biochemical mechanisms by which apoptosis, cell signaling, complement, lipids, and viruses contribute to disease expression, and detail both immune and nonimmune cell function in rheumatic diseases. Their review of the major rheumatic diseases integrates the cellular, biochemical, and molecular biological mechanisms that are important in rheumatic disease pathogenesis. The authors also discuss the molecular and cellular mechanisms of action following the administration of the principal drugs used in rheumatology. Path-breaking and illuminating, Principles of Molecular Rheumatology expands the envelope of clinical understanding to reveal the biological roots underlying rheumatologic disease, as well as the nature and roles of the powerful new therapeutics now emerging for its optimal treatment.

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Produktdetails

• Verlag: Humana Press
• Seitenzahl: 542
• Erscheinungstermin: 24. Juli 2000
• Englisch
• ISBN-13: 9781592590186
• Artikelnr.: 43995470

Inhaltsangabe

Part I. Molecular Mechanisms in Rheumatic Diseases
Genetics
Peter K. Gregersen
Viruses
Andras Perl
Apoptosis
John D. Mountz, Hui-Chen Hsu, Huang-Ge Zhang, and Tong Zhou
Humoral Response
Gary S. Gilkeson
T-Cell Signaling
Gary A. Koretzky and Erik J. Peterson
Adhesion and Costimulatory Molecules
Vassiliki A. Boussiotis, Gordon J. Freeman, and Lee M. Nadler
Transcription Factors
Henry K. Wong
Immune Complexes
Mark H. Wener
Complement
V. Michael Holers
Eicosanoids and Other Bioactive Lipids
Leslie J. Crofford
Collagens
Sergio A. Jiménez
Part II. Cellular Mechanisms in Rheumatic Diseases
T-Lymphocytes
Nilamadhab Mishra and Gary M. Kammer
B-Lymphocytes
Robert F. Ashman
Monocytes and Macrophages
James M. K. Chan and Sharon M. Wahl
Polymorphonuclear Cells
Michael H. Pillinger, Pamela B. Rosenthal, and Bruce N. Cronstein
Synoviocytes
David E. Yocum
Chondrocytes
Tariq M. Haqqi, Donald D. Anthony, and Charles J. Malemud
Osteoblasts and Osteoclasts
Stavros C. Manolagas
Animal Models
Thomas J. Lang and Charles S. Via
Part III. Pathogenesis of Rheumatic Diseases
Systemic Lupus Erythematosus
Stamatis-Nick C. Liossis and George C. Tsokos
Rheumatoid Arthritis
Richard M. Pope and Harris Perlman
Inflammatory Myopathies
Norbert Goebels and Reinhard Hohlfeld
Systemic Sclerosis
Timothy M. Wright
Vasculitis
Jörg J. Goronzy and Cornelia M. Weyand
Osteoarthritis
Robin Poole and Ginette Webb
Osteoporosis
Stavros C. Manolagas
Heritable Disorders of Connective Tissue
Petros Tsipouras
Part IV. Molecular Aspects of Treatment of Rheumatic Diseases
Corticosteroids
Henry K. Wong and George C. Tsokos
Cytotoxic Drugs
David A. Fox and W. Joseph McCune
Complement Inhibitors
Savvas C. Makrides
Cytokine Response Modifiers
Richard E. Jones and Larry W. Moreland
Restoration of Immune Tolerance
Woodruff Emlen
Metalloproteases and Their Modulation as Treatment in Osteoarthritis
Johanne Martel-Pelletier, Ginette Tardif, Julio Fernandes, and Jean-Pierre Pelletier
Gene Therapy
Robert P. Kimberly

Rezensionen

"Unlike previous classical textbooks of rheumatology in which the clinical and therapeutic approaches to rheumatic disease are discussed, this one is unique in the contributors' ability to integrate the clinical approach to rheumatic disease with the latest biochemical, cellular, and molecular mechanisms at play in these disorders. This approach allows clinical rheumatologists to gain a better understanding of the cellular and molecular biology that underlies the diseases we treat and the therapeutics we use to treat these disorders.."-Doody's Health Science Book Review Journal "It contains many figures of good quality." - Journal of Endocrine Genetics "Unlike previous classical textbooks of rheumatology in which the clinical and therapeutic approaches to rheumatic disease are discussed, this one is unique in the contributors' ability to integrate the clinical approach to rheumatic disease with the latest biochemical, cellular, and molecular mechanisms at play in these disorders. This approach allows clinical rheumatologists to gain a better understanding of the cellular and molecular biology that underlies the diseases we treat and the therapeutics we use to treat these disorders." - Doody Publishing