Post-transcriptional Gene Regulation in Human Disease (eBook, ePUB)

Redaktion: Jain, Buddhi Prakash; Sharma, Tapan; Goswami, Shyamal K

• Format: ePub

Produktbeschreibung

Post-transcriptional Gene Regulation in Human Disease, a new volume in the Translational Epigenetics book series, offers a thorough overview and discussion of post-transcriptional genetic control mechanisms and their roles across various pathologies and human developmental outcomes, along with regulatory mechanisms targeted for therapeutic approaches. The book is broadly divided in two parts: early chapters describe the basics of post-transcriptional gene regulation, associated epigenetic mechanisms, the role of RNA binding proteins, the evolution of post-transcriptional gene regulation, and methods to study these mechanisms. The second half of the book includes deeper discussion of post-transcriptional gene regulation across specific diseases and therapeutics targets. Various post-transcriptional events, including alternative splicing and polyadenylation, mRNA stability, and miRNAs and their involvement in the disease progression, are examined in detail.

• Includes full-color imagery illustrating key concepts and post-transcriptional disease processes, as well as descriptions of methods for studying post-transcriptional gene regulation
• Presents fundamental knowledge, molecular and biochemical mechanisms, and recent findings in concise and easily understandable formats
• Features a summary and conclusion at the end of each chapter

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Produktdetails

• Verlag: Elsevier Science & Techn.
• Seitenzahl: 394
• Erscheinungstermin: 12. August 2022
• Englisch
• ISBN-13: 9780323914246
• Artikelnr.: 65154280

Inhaltsangabe

1. Regulation of Gene Expression in Mammals: An Overview
2. Post Transcriptional Gene Regulation: An Overview
3. Methods to Study Post-Transcriptional Regulation of Gene Expression
4. Epigenetic Regulation of Post-Transcriptional Machinery
5. Post-Transcriptional Regulation: A Less Explored Territory in the World
of Neurodegenerative Diseases
6. Role of Post-Transcriptional Gene Regulation in Hematological
Malignancies
7. Post-Transcriptional Gene Regulation in Solid Tumors
8. A Comprehensive View of the Prostate Cancer Metastasis and Role of
Androgen Receptor Splice Variants
9. Post-Transcriptional Gene Regulation in Cardiorenal Syndrome
10. Noncoding RNAs as Modulators of Post-Transcriptional Changes and Their
Role in CVDs
11. microRNAs as Critical Regulators in Heart Development and Diseases
12. MicroRNA Regulation in Autoimmune Diseases
13. Post-Transcriptional Regulation of Inflammatory Disorder
14. Post-Transcriptional Gene Regulation in Metabolic Syndrome
15. Post-Transcriptional Regulation of HIV-1 Gene Expression: Role of Viral
and Host Factors
16. Post-Transcriptional Regulation of Gene Expression in Entamoeba
histolytica
17. Post-Transcriptional Regulation of Gene Expression in the Human Malaria
Parasite Plasmodium falciparum
18. Hepcidin-Induced Degradation of Iron Exporter Ferroportin Determines
Anemia of Chronic Diseases
19. Post-Transcriptional Regulation of Genes and Mitochondrial Disorder