Philosophy of Molecular Medicine (eBook, ePUB)

Foundational Issues in Research and Practice
Redaktion: Boniolo, Giovanni; Nathan, Marco J.

• Format: ePub

Produktbeschreibung

Despite its prominence in scientific research, molecular medicine has not received sufficient attention by the philosophical community. Philosophy of Molecular Medicine: Foundational Issues in Theory and Practice aims at a systematic investigation of a number of foundational issues in the field of molecular medicine. The volume is organized around four broad modules focusing, respectively, on the following key aspects: What are the nature, scope and limits of molecular medicine? How does it provide explanations? How does it represent and model phenomena of interest? How does it infer new knowledge from data and experiments? The essays collected here, authored by prominent scientists and philosophers of science, focus on a handful of mainstream topics in the philosophical literature, such as causation, explanation, modeling, and scientific inference. These previously unpublished contributions shed new light on these traditional topics by integrating them with problems, methods, and results from three prominent areas of contemporary biomedical science: basic research, translational and clinical research, and clinical practice.

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Produktdetails

• Verlag: Taylor & Francis
• Seitenzahl: 296
• Erscheinungstermin: 18. November 2016
• Englisch
• ISBN-13: 9781317378341
• Artikelnr.: 47140108

Autorenporträt

Giovanni Boniolo (degrees in Physics and in Philosophy) is Professor of Philosophy of Science and Medical Humanities at the Università di Ferrara, and Anna Boyksen Fellow at the Institute for Advanced Study, Technische Universität München. He has published 13 books (plus 12 books edited) and about 200 research articles. Marco J. Nathan is Assistant Professor of Philosophy at the University of Denver. His work has been published in various philosophical and scientific venues, including Noûs, Philosophy of Science, British Journal for Philosophy of Science, Nephrology Dialysis and Transplantation, Biology and Philosophy, and Synthese.

Inhaltsangabe

Introduction
Giovanni Boniolo and Marco J. Nathan
Part 1: Nature, Origins, and Scope
Chap. 1: Molecular medicine: the clinical method enters the lab. What tumor
heterogeneity and primary tumor culture teach us
Giovanni Boniolo
Chap. 2: Personalized Medicine: Historical Roots of a Medical Model
Mariacarla Gadebusch Bondio and Francesco Spöring
Chap. 3: From the concept of genetic disease to the geneticization of
diseases: analyzing and solving the paradox of contemporary medical
genetics
Marie Darrason
Part 2: Explanation
Chap. 4: Molecular complexity: Why has psychiatry not been revolutionized
by genomics (yet)?
Maël Lemoine
Chap. 5: How cancer spreads: reconceptualizing a disease
Katherine E. Liu, Alan C. Love, and Michael Travisano
Chap. 6: Evolutionary Perspectives on Molecular Medicine: Cancer from an
Evolutionary Perspective
Anya Plutynski
Part 3: Representation and Modeling
Chap. 7: Towards a Notion of Intervention in Big-Data Biology and Molecular
Medicine
Federico Boem and Emanuele Ratti
Chap. 8: Pathways to the clinic: cancer stem cells and challenges for
translational research
Melinda Bonnie Fagan
Chap. 9: Counterfactual Reasoning in Molecular Medicine
Marco J. Nathan
Part 4: Inference
Chap. 10: Forms of Extrapolation in Molecular Medicine
Pierre-Luc Germain and Tudor Baetu
Chap. 11: Testing Oncological Treatments in the Era of Personalized
Medicine
David Teira
Chap. 12: Opportunities and challenges of molecular epidemiology
Federica Russo and Paolo Vineis