Pharmacogenomics in Clinical Therapeutics (eBook, PDF)

Redaktion: Langman, Loralie J.; Dasgupta, Amitava

• Format: PDF

Produktbeschreibung

Pharmacogenomics is the basis of personalized medicine which will be the medicine of the future. Through both reducing the numbers of adverse drug reactions and improving the use of existing drugs in targeted populations, pharmacogenomics represents a real advance on traditional therapeutic drug monitoring. Pharmacogenomics in Clinical Therapeutics provides an introduction to the principles of pharmacogenomics before addressing the pharmacogenomic aspects of key therapeutic areas such as warfarin therapy, cancer chemotherapy, therapy with immunosuppressants, antiretroviral therapy, and psychoactive drugs. It also includes methods of pharmacogenomic testing and the pharmacogenomic aspects of drug-drug interactions. From a team of expert contributors, Pharmacogenomics in Clinical Therapeutics is a comprehensive overview of the current state of pharmacogenomics in pharmacotherapy for all clinicians, pharmacologists and clinical laboratory professionals. It is also a guide for practicing clinicians and health care professionals to the basic principles of pharmacogenomics, laboratory tests currently available to aid clinicians, and the future promise of this developing field.

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Produktdetails

• Verlag: John Wiley & Sons
• Seitenzahl: 400
• Erscheinungstermin: 31. Januar 2012
• Englisch
• ISBN-13: 9781119959571
• Artikelnr.: 38447731

Autorenporträt

Amitava Dasgupta, Ph.D, DABCC, FACB, Professor of Pathology and Laboratory Medicine, University of Texas Health Sciences Center at Houston, Houston, TX. Loralie J. Langman, Ph.D, DABCC, FACB, Associate Professor of Laboratory Medicine, Mayo Clinic, Rochester, MN.

Inhaltsangabe

List of Contributors
vii Preface
ix 1 Pharmacogenomics Principles: Introduction to Personalized Medicine
1 Parvaz Madadi
PhD and Gideon Koren
MD 2 Traditional Therapeutic Drug Monitoring and Pharmacogenomics: Are They Complementary? 15 Christine L.H. Snozek
PhD
Loralie J. Langman
PhD
and Amitava Dasgupta
Ph.D 3 Pharmacogenomics Aspect of Warfarin Therapy
26 Matthew D. Krasowski
MD
PhD 4 Pharmacogenetics and Cancer Chemotherapy
39 Christine L.H. Snozek 5 Pharmacogenomic Considerations in Anesthesia and Pain Management
53 Christine M. Formea
PharmD and Wayne T. Nicholson
MD
PharmD 6 Pharmacogenomics of Immunosuppressants
70 Nicolas Picard
PharmD
PhD and Pierre Marquet
MD
PhD 7 Pharmacogenomics of Cardiovascular Drugs
98 Linnea M. Baudhuin
PhD 8 Pharmacogenomic Aspects of Antiretroviral Therapy
127 Natella Y. Rakhmanina
MD
PhD and John N. van den Anker
MD
PhD 9 Pharmacogenetics of Psychoactive Drugs
144 Jorge L. Sepulveda
MD
PhD 10 Pharmacogenomic Aspects of Adverse Drug-Drug Interactions
176 Loralie J. Langman
PhD and Christine L.H. Snozek
PhD 11 Microarray Technology and Other Methods in Pharmacogenomics Testing
185 Jorge L. Sepulveda
MD
PhD 12 Pharmacogenetic Testing in the Clinical Laboratory Environment
201 Mark P. Borgman
PhD and Mark W. Linder
PhD Index
225