Pathogenesis of Bacterial Infections in Animals (eBook, PDF)

Redaktion: Prescott, John F.; Vázquez-Boland, José A.; Rycroft, Andrew N.; Boyce, John D.; Immerseel, Filip van; MacInnes, Janet I.

• Format: PDF

Produktbeschreibung

PATHOGENESIS OF BACTERIAL INFECTIONS IN ANIMALS Comprehensive review of the major bacterial pathogens of animals, focusing on the current understanding of how they cause disease Pathogenesis of Bacterial Infections in Animals, Fifth Edition is a specialist reference that provides a comprehensive review of bacterial pathogens in animals and their complex interplay with disease processes, offering a complete understanding of how bacteria cause disease in animals. It covers the many recent advances in the field including the newest taxonomies. In this revised and long anticipated fifth edition, additional introductory chapters have been added to set the material in context, and more figures added to integrate and improve understanding and comprehension throughout the text. A companion website presents the figures from the book in PowerPoint and references. This detailed reference includes novel approaches to controlling bacterial pathogens in the light of growing concerns about antimicrobial resistance, with more than 70 expert authors sharing their wisdom on the topic. While molecular pathogenesis is a major aspect in almost every chapter, the authors have been careful to place pathogens in their broader context. Pathogenesis of Bacterial Infections in Animals, Fifth Edition also contains information on: * Themes in bacterial pathogenesis, covering the basic elements of pathogenesis, concepts of virulence, host-pathogen interactions and communication, and pathogenesis in the post-genomic era * Evolution of bacterial pathogens, covering what they are and how they emerge, along with sources of genetic diversity, population structure, and genome plasticity * Understanding of pathogenesis through pathogenomics and bioinformatics, including how mutations generate pathogen diversity, and an overview of genome sequencing technologies * Subversion of the immune response by bacterial pathogens, covering subversion of both innate responses and adaptive immunity Pathogenesis of Bacterial Infections in Animals, Fifth Edition is an essential resource for graduate students in veterinary medicine and animal science, and for veterinary microbiologists, pathologists, infectious disease experts, and others interested in bacterial disease. It is the only book to cover this topic to this depth through the wealth of insight of dozens of qualified and practicing professionals.

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Produktdetails

• Verlag: John Wiley & Sons
• Seitenzahl: 816
• Erscheinungstermin: 11. August 2022
• Englisch
• ISBN-13: 9781119754824
• Artikelnr.: 65464557

Autorenporträt

John F. Prescott is University Professor Emeritus at the University of Guelph, in Guelph, Ontario, Canada. Janet I. MacInnes is Professor Emerita at the University of Guelph in Guelph, Ontario, Canada. Filip Van Immerseel is Professor at Ghent University in Merelbeke, Belgium. John D. Boyce is Associate Professor at Monash Biomedicine Discovery Institute, Monash University, in Clayton, Victoria, Australia. Andrew N. Rycroft is Professor at the Royal Veterinary College, in Hatfield, Hertfordshire, United Kingdom. José A. Vázquez-Boland is Professor at the University of Edinburgh in Edinburgh, United Kingdom.

Inhaltsangabe

Preface xv

List of Contributors xvii

About the Companion Website xxv

1 Themes in Bacterial Pathogenesis 1
John F. Prescott

Introduction 1

The Basic Elements of Bacterial Pathogenesis 1

Concepts of Bacterial Virulence are Being Refined 5

Host-Pathogen Communications are Critical 9

Pathogenesis in the Post-Genomic Era 11

Gaps in Knowledge and Anticipated Directions 13

References 13

2 Evolution of Bacterial Pathogens 15
Patrick Boerlin

What are Pathogens and How Do They Emerge? 15

Bacterial Fitness and Virulence 17

Sources of Genetic Diversity, Population Structure, and Genome Plasticity 18

Pathogenicity Islands 20

Bacteriophages and Their Role in Pathogen Evolution and Virulence 22

Examples of Virulence Evolution 23

Gaps in Knowledge and Anticipated Directions 27

References 28

3 Understanding Pathogenesis Through Pathogenomics and Bioinformatics 32
Gregorio Iraola and John D. Boyce

Introduction 32

How Mutations Generate Bacterial Diversity 34

Genome Sequencing Technologies 36

Genome Assembly 38

Gene Prediction and Annotation 39

Defining Prokaryotic Species from Genomes 41

The Pangenome Concept, Reconstruction, and Comparative Analyses 41

Phylogenomics and Genome-Wide Association Studies 42

Functional Genomics for Understanding Host-Pathogen Interactions 44

Reverse Vaccinology 48

Gaps in Knowledge and Anticipated Directions 51

References 52

4 Experimental Approaches to Understanding Pathogenesis 57
Francesca L. Short and Janet I. MacInnes

Introduction 57

Testing Koch's Postulates 57

Virulence Factors and Main Steps in Pathogenesis 58

Molecular Koch's Postulates 60

Refining Animal Usage 60

Experimental Approaches for Virulence Factor Discovery and Validation 62

Approaches for Virulence Factor Discovery 63

Gene Disruption Approaches for Virulence Factor Discovery 71

Bringing It All Together: Validation and Further Characterization of Virulence Factors 73

Two Stories of Virulence Factor Discovery and Characterization: Pasteurella multocida Capsule, and Mycoplasma bovis Adhesins 74

Gaps in Knowledge and Anticipated Directions 75

References 76

5 Subversion of the Immune Response by Bacterial Pathogens 79
Douglas C. Hodgins, Raveendra R. Kulkarni, and Patricia E. Shewen

Introduction 79

Subversion of Innate Responses 80

Subversion of Adaptive Immunity 85

Manipulation of Cell Fate 88

Non-Coding RNA and Host-Pathogen Interactions 91

Epigenetic and Genetic Modulation 92

Gaps in Knowledge and Anticipated Directions 94

References 94

6 Chinks in the Armor 99
Allison C. Leonard, Celine Stoica, and Georgina Cox

Introduction 99

Virulence Factors: Pathogenesis-Based Targets to Combat Bacterial Pathogens 99

Targeting Bacterial Host Cell Adhesion and Biofilm Formation 100

Quorum Sensing Inhibition 104

Interfering with Two-Component Regulatory Systems 105

Inhibiting Bacterial Motility 106

Toxin Neutralization 107

Inhibitors of Bacterial Secretion Systems 107

Targeting Nutrient Acquisition: Starving the Pathogen 110

Antivirulence Phage Therapy 111

Bacterial Drug Efflux Pumps as Pathogenesis-Based Antibacterial Targets 112

Gaps in Knowledge and Anticipated Directions 112

Rezensionen

"The book is well-produced and a useful update on bacterial pathogenesis from a genomics standpoint. It belongs in the diagnostic laboratory, and not just on the bacteriologist's shelf." - Journal of Veterinary Diagnostic Investigation, 2023, Vol. 35(2) 217-218