Particle Toxicology (eBook, PDF)

Redaktion: Donaldson, Ken; Borm, Paul

• Format: PDF

Produktbeschreibung

Particle Toxicology integrates the current knowledge in particulate physico-chemistry, cell/molecular biology and toxicology into a single volume. While using the classical toxicology paradigm of exposure - dose - response, it provides reviews on the mechanisms and properties of pathogenic particles and their pathogenic effects. The text describes how these actions may be related to specific site of deposition, translocation, particle composition, shape and the outcome of various pathogenic processes involving pro-inflammatory effects and inflammatory signaling, oxidative and nitrosative stress, particulate interactions in the pulmonary, cardiovascular, and central nervous systems, as well as genotoxic effects of ultrafine and other particles.

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Produktdetails

• Verlag: Taylor & Francis
• Seitenzahl: 456
• Erscheinungstermin: 21. Dezember 2006
• Englisch
• ISBN-13: 9781420003147
• Artikelnr.: 53315705

Autorenporträt

Donaldson, Ken; Borm, Paul

Inhaltsangabe

An Introduction to Particle Toxicology: From Coal Mining to Nanotechnology
Mineralogy and Structure of Pathogenic Particles
Particle Dosimetry: Deposition and Clearance from the Respiratory Tract and Translocation towards Extra-Pulmonary Sites
Particulate Air Pollutants and Small Airway Remodeling
Particle-Mediated Extracellular Oxidative Stress in the Lung
Particles and Cellular Oxidative and Nitrosative Stress
Interaction of Particles with Membranes
B. Rothen-Rutishauser
Particle-Associated Metals and Oxidative Stress in Signaling
Proinflammatory Effects of Particles on Macrophages and Epithelial Cells
Cell-Signaling Pathways Elicited by Particlates
Particle-Associated Organics and Proinflammatory Signaling
The Asbestos Model of Interstitial Pulmonary Fibrosis: TNF-a and TGF-b1 as Mediators of Asbestos-Induced Lung Fibrogenesis
Effects of Particles on the Immune System
Effects of Particles on the Cardiovascular System
Susceptibility to Particle Effects
Genotoxic Effects of Particles
Approaches to the Toxicological Testing of Particles
K. Donaldson
Models for Testing the Pulmonary Toxicity of Particles: Lund Bioassay Screening Studies in Male Rats with a New Formulation of TiO2 Particulates
Air Pollution and Human Brain Pathology: A Role for Air Pollutants in the Pathogensis of Alzheimer's Disease
Biologically-Based Lung Dosimetry and Exposure-Dose-Response Models for Poorly Soluble Inhaled Particles
Nanoparticles in Medicine
The Toxicology of Inhaled Particles: Summing Up an Emerging Conceptual Framework
Index