Nuclear Organization in Development and Disease (eBook, PDF)

Redaktion: Chadwick, Derek J.; Goode, Jamie A.

• Format: PDF

Produktbeschreibung

This book draws together contributions from cell and developmental biologists, structural biologists, geneticists and clinical scientists aimed at a better understanding of the cellular and molecular basis of these diseases. Topics include: * How nuclear structure and location within a nucleus affect gene expression * Chromatin organization and cell differentiation * The nature of the interactions between the nuclear envelope and the cytoskeleton * The extent to which the cytoskeleton mediates communication between the cell membrane and nucleus in regulating gene expression and whether disruption of such communication might underlie the disease processes It is hoped that a better understanding of the mechanisms leading to disease pathogenesis may ultimately lead to more rational and appropriate treatments.

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Produktdetails

• Verlag: John Wiley & Sons
• Seitenzahl: 300
• Erscheinungstermin: 5. August 2005
• Englisch
• ISBN-13: 9780470093740
• Artikelnr.: 37290334

Autorenporträt

The Novartis Foundation is an international scientific and educational charity which promotes the study and general knowledge of science and in particular encourages international co-operation in scientific research. Chair: Robert D. Goldman

Inhaltsangabe

Chair's Introduction (R. Goldman). Nuclear lamins: building blocks of
nuclear structure and function (R. Goldman, et al.). Aspects of nuclear
envelope dynamics in mitotic cells (B. Burke, et al.). Components of the
nuclear envelope and their role in human disease (H. Worman). Nuclear
membrane protein emerin: roles in gene regulation, actin dynamics and human
disease (K. Wilson, et al.). Identification of novel integral membrane
proteins of the nuclear envelope with potential disease links using
subtractive proteomics (E. Schirmer, et al.). Genetics of laminopathies (R.
Ben Yaou, et al.). Muscular dystrophies related to the cytoskeleton/nuclear
envelope (K. Nowak, et al.). Skeletal and cardiac muscle defects in a
murine model of Emery-Dreifuss muscular dystrophy (M. Grattan, et al.).
Multiple pathways tether telomeres and silent chromatin at the nuclear
periphery: functional implications for Sir-mediated repression (A. Taddei,
et al.). A-type lamin-linked lipodystrophies (C. Vigouroux and J. Capeau).
Cytoskeletal defects in amyotrophic lateral sclerosis (motor neuron
disease) (J. Julien, et al.). LMNA mutations in progeroid syndromes (S.
Huang, et al.). A genetic approach to study the role of nuclear envelope
components in nuclear positioning (D. Starr and M. Han). General Discussion
I. A lamin-dependent pathway that regulates nuclear organization, cell
cycle progression and germ cell development (A. Margalit, et al.).
Mutations in the mouse Lmna gene causing progeria, muscular dystrophy and
cardiomyopathy (S. Kozlov, et al.). The nuclear membrane and
mechanotransduction: impaired nuclear mechanics and mechanotransduction in
lamin A/C-deficient cells (J. Lammerding and R. Lee). Chair's summing up
(R. Goldman). Index of contributors. Subject index.

Rezensionen

" an excellent guide to research in the field of nuclear organization, and an encouragement for students interested in learning how great minds tackle complex problems." ( Doody s Health Services )