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Novel Pharmacological Interventions for Alcoholism identifies priorities for focusing alcoholism and addiction research efforts during the coming years. A number of important issues concerning methodology, mechanisms, clinical evaluation, and pharmaceutical aspects are discussed. This book is also a plea for a greater degree of collaboration among academics, pharmaceutical physicians and scientists, and drug regulators; it demonstrates that progress in understanding and fighting addiction and alcoholism is possible in the foreseeable future.
Novel Pharmacological Interventions for Alcoholism identifies priorities for focusing alcoholism and addiction research efforts during the coming years. A number of important issues concerning methodology, mechanisms, clinical evaluation, and pharmaceutical aspects are discussed. This book is also a plea for a greater degree of collaboration among academics, pharmaceutical physicians and scientists, and drug regulators; it demonstrates that progress in understanding and fighting addiction and alcoholism is possible in the foreseeable future.
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I. General Methodologic Issues.- 1. Animal Models for Testing Drug Effects on Alcohol Consumption.- 2. Animal Models for Screening Drugs to Decrease Alcohol Consumption.- 3. Medications for Alcohol Abuse and Dependence: Methodology for Clinical Studies.- 4. Some Issues in the Evaluation of a Pharmacotherapy of Alcoholism.- II. Serotonin and Alcohol Consumption.- 5. Serotonin and Alcohol Consumption.- 6. Serotonergic and Dopaminergic Involvement in Ethanol Intake.- 7. Serotonin and Alcohol Consumption.- 8. Basic and Clinical Studies on Serotonin, Alcohol, and Alcoholism.- 9. Evaluation of the Effects of Serotonin Uptake Inhibitors in Alcoholics: A Review.- III. Opioids and Alcohol Consumption.- 10. Opioids Modulate Rats Propensities to Take Alcoholic Beverages.- 11. The Enkephalinergic System and Maintenance of Ethanol Drinking.- 12. The Relationship of Alcohol Drinking and Endogenous Opioids: The Opioid Compensation Hypothesis.- 13. Naltrexone in the Treatment of Alcohol Dependence: Preliminary Findings.- IV. The Role of Other Neurotransmitters in Regulating Alcohol Intake.- 14. Neurotransmitter Systems Regulating Alcohol Intake.- 15. Agents Which Modify Channels as Potential Treatments in Alcohol Withdrawal.- 16. Management of Alcohol Consumption with Angiotensin Converting Enzyme Inhibitors: A Review of the Animal Findings.- 17. Enalapril Does not Decrease Alcohol Intake in Normotensive Alcoholics.- Poster Papers.- General Methodologic Issues.- Rational vs. Reflexive Alcohol Drinking.- Rats Intakes of Different Alcoholic Beverages.- Drug-induced Specific and Nonspecific Changes in Voluntary Ethanol Intake by Rats.- Rationale for Alcoholism Treatment Based on Inhibition of Aldehyde Dehydrogenase.- The Effect of Low Alcohol Beverages on Alcoholism Levels in Canada in 1986.- Alcoholism, Antisocial Behavior, and Family History: A Synopisis.- Perception of Whether Drug or Placebo has been Administered is a Determinant of Drinking Reduction.- Disulfiram Treatment of Alcoholism.- Controlled Release Disulfiram (DS) Implant.- Depot Disulfiram: Pharmacokinetics and Clinical Effects During 28 Days Following a Single Subcutaneous Dose.- Mildly Intoxicating Levels of Alcohol Produces Direct Myocardial Depression on Left Ventricular Performance.- A Human Model for Testing Drug-induced Concomitant Variations in Alcohol Consumption and Desire to Drink.- Serotonin and Alcohol Consumption.- Mianserin, a Serotonergic Antagonist, and Intake of an Alcoholic Beverage.- Effects of the 5-HT Uptake Inhibitor, Sertraline, on Ethanol, Water and Food Consumption.- Fluvoxamine is Poorly Tolerated by Alcoholics.- Opioids and Alcohol Consumption.- Effects of Differential Handling on Rats Intake of Alcohol.- Stereoselectivity of Opioids Effects on Intake of an Alcoholic Beverage.- Metabolites of Morphine and Intake of an Alcoholic Beverage.- Peripheral Administrations of TIQS and Intake of an Alcoholic Beverage.- Morphine Enhances Intake of an Alcoholic Beverage Regardless of Type of Flavoring.- LY78335, an Inhibitor of Phenylethanolamine N-methyltransferase, and Rats Intake of an Alcoholic Beverage.- LY255582, an Opioid Antagonist, and Intake of an Alcoholic Beverage.- Effects of Naltrexone on the Cognitive Functioning of Recently Abstinent Alcohol Dependent Patients.- The Role of Other Neurotransmitters in Regulating Alcohol Intake.- Calcium-diacetyl-homotaurinate which Prevents Relapse in Weaned Alcoholics Decreases the Action of Excitatory Amino Acids in Neocortical Neurons of the Rat in Vitro.- THC, an Active Ingredient in Marijuana, and Rats Intake of a Sweetened Alcoholic Beverage.- Cocaine and Rats Intake of an Alcoholic Beverage.- Calcium-acetylhomotaurinate for Maintaining Abstinence in Weaned Alcoholic Patients: A Placebo-controlled Double-blind Multicenter Study.- Effects of Angiotensin Converting Enzyme Inhibitors on Free Choice Ethanol Consumption by Rats.- Calcium Channel Antagonists Attenuate the Alcohol Dependence Syndrome.- Pharmacologic
I. General Methodologic Issues.- 1. Animal Models for Testing Drug Effects on Alcohol Consumption.- 2. Animal Models for Screening Drugs to Decrease Alcohol Consumption.- 3. Medications for Alcohol Abuse and Dependence: Methodology for Clinical Studies.- 4. Some Issues in the Evaluation of a Pharmacotherapy of Alcoholism.- II. Serotonin and Alcohol Consumption.- 5. Serotonin and Alcohol Consumption.- 6. Serotonergic and Dopaminergic Involvement in Ethanol Intake.- 7. Serotonin and Alcohol Consumption.- 8. Basic and Clinical Studies on Serotonin, Alcohol, and Alcoholism.- 9. Evaluation of the Effects of Serotonin Uptake Inhibitors in Alcoholics: A Review.- III. Opioids and Alcohol Consumption.- 10. Opioids Modulate Rats Propensities to Take Alcoholic Beverages.- 11. The Enkephalinergic System and Maintenance of Ethanol Drinking.- 12. The Relationship of Alcohol Drinking and Endogenous Opioids: The Opioid Compensation Hypothesis.- 13. Naltrexone in the Treatment of Alcohol Dependence: Preliminary Findings.- IV. The Role of Other Neurotransmitters in Regulating Alcohol Intake.- 14. Neurotransmitter Systems Regulating Alcohol Intake.- 15. Agents Which Modify Channels as Potential Treatments in Alcohol Withdrawal.- 16. Management of Alcohol Consumption with Angiotensin Converting Enzyme Inhibitors: A Review of the Animal Findings.- 17. Enalapril Does not Decrease Alcohol Intake in Normotensive Alcoholics.- Poster Papers.- General Methodologic Issues.- Rational vs. Reflexive Alcohol Drinking.- Rats Intakes of Different Alcoholic Beverages.- Drug-induced Specific and Nonspecific Changes in Voluntary Ethanol Intake by Rats.- Rationale for Alcoholism Treatment Based on Inhibition of Aldehyde Dehydrogenase.- The Effect of Low Alcohol Beverages on Alcoholism Levels in Canada in 1986.- Alcoholism, Antisocial Behavior, and Family History: A Synopisis.- Perception of Whether Drug or Placebo has been Administered is a Determinant of Drinking Reduction.- Disulfiram Treatment of Alcoholism.- Controlled Release Disulfiram (DS) Implant.- Depot Disulfiram: Pharmacokinetics and Clinical Effects During 28 Days Following a Single Subcutaneous Dose.- Mildly Intoxicating Levels of Alcohol Produces Direct Myocardial Depression on Left Ventricular Performance.- A Human Model for Testing Drug-induced Concomitant Variations in Alcohol Consumption and Desire to Drink.- Serotonin and Alcohol Consumption.- Mianserin, a Serotonergic Antagonist, and Intake of an Alcoholic Beverage.- Effects of the 5-HT Uptake Inhibitor, Sertraline, on Ethanol, Water and Food Consumption.- Fluvoxamine is Poorly Tolerated by Alcoholics.- Opioids and Alcohol Consumption.- Effects of Differential Handling on Rats Intake of Alcohol.- Stereoselectivity of Opioids Effects on Intake of an Alcoholic Beverage.- Metabolites of Morphine and Intake of an Alcoholic Beverage.- Peripheral Administrations of TIQS and Intake of an Alcoholic Beverage.- Morphine Enhances Intake of an Alcoholic Beverage Regardless of Type of Flavoring.- LY78335, an Inhibitor of Phenylethanolamine N-methyltransferase, and Rats Intake of an Alcoholic Beverage.- LY255582, an Opioid Antagonist, and Intake of an Alcoholic Beverage.- Effects of Naltrexone on the Cognitive Functioning of Recently Abstinent Alcohol Dependent Patients.- The Role of Other Neurotransmitters in Regulating Alcohol Intake.- Calcium-diacetyl-homotaurinate which Prevents Relapse in Weaned Alcoholics Decreases the Action of Excitatory Amino Acids in Neocortical Neurons of the Rat in Vitro.- THC, an Active Ingredient in Marijuana, and Rats Intake of a Sweetened Alcoholic Beverage.- Cocaine and Rats Intake of an Alcoholic Beverage.- Calcium-acetylhomotaurinate for Maintaining Abstinence in Weaned Alcoholic Patients: A Placebo-controlled Double-blind Multicenter Study.- Effects of Angiotensin Converting Enzyme Inhibitors on Free Choice Ethanol Consumption by Rats.- Calcium Channel Antagonists Attenuate the Alcohol Dependence Syndrome.- Pharmacologic
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