Neurotransmitter Transporters (eBook, PDF)

Structure, Function, and Regulation
Redaktion: Reith, Maarten E. A.

• Format: PDF

Produktbeschreibung

Integrating the many recent advances from DNA technology, Maarten Reith and his contributors fully update all the material in his highly acclaimed first edition, expanding it to include the important progress made in characterizing the structure, function, regulation, and physiological relevance of each transporter. The new material includes discussions of gene organization and the relationship of polymorphisms of monoamine transporters with a variety of diseases, transgenic animals carrying altered genes for plasma membrane monoamine transporters, and the regulation of transporters by trafficking in relation to their phosphorylation state. Also addressed are transporter imaging techniques that allow in vivo measurement in men and animals, chimera and site-directed mutagenesis studies, and transporter electrophysiology. Many chapters will be of interest to physicians carrying out imaging and postmortem measurements of neurotransmitter transporters in the human brain, and to physicians who study the relation of gene linkages and polymorphisms to psychiatric and other complex human diseases. Complete and up-to-date, Neurotransmitter Transporters: Structure, Function, and Regulation, Second Edition continues to be the most informative and useful review of this most active field, allowing comparison between the characteristics of various neurotransmitter transporters and their biological roles in such a way that progress for one transporter can help move work on another transporter forward.

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Produktdetails

• Verlag: Humana Press
• Seitenzahl: 518
• Erscheinungstermin: 15. Mai 2002
• Englisch
• ISBN-13: 9781592591589
• Artikelnr.: 44054010

Inhaltsangabe

1 - Regulation of Monoamine Transporters: Regulated Phosphorylation, Dephosphorylation, and Trafficking.- 2 - Mechanisms of Biogenic Amine Neurotransmitter Transporters.- 3 - Structure-Function Relationships for Biogenic Amine Neurotransmitter Transporters.- 4 - Gene Organization and Polymorphisms of Monoamine Transporters: Relationship to Psychiatric and Other Complex Diseases.- 5 - Monoamine Transporters: Their Role in Maintaining Neuronal Homeostasis.- 6 - Family of Sodium-Coupled Transporters for GABA, Glycine, Proline, Betaine, Taurine, and Creatine: Pharmacology, Physiology, and Regulation.- 7 - Sodium-Coupled GABA and Glutamate Transporters: Structure and Function.- 8 - The High-Affinity Glutamate and Neutral Amino-Acid Transporter Family: Structure, Function, and Physiological Relevance.- 9 - Vesicular Neurotransmitter Transporters: Pharmacology, Biochemistry, and Molecular Analysis.- 10 - Neurotransmitter-Transporter Proteins: Post-Translational Modifications.- 11 - Dopamine-Transporter Uptake Blockers: Structure-Activity Relationships.- 12 - Imaging the Brain Dopamine Transporter Using PET and SPECT.- 13 - In Vitro and In Vivo Imaging of the Human Dopamine Transporter in Cocaine Abusers.

Rezensionen

From Reviews of the first edition...

"...highly informative and useful..."-Trends in Neurosciences