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The Third International Symposium on Neurotransmitter Receptors was held in Hiroshima at a time when the entire field of neurotransmitter receptors in the brain is progressing at an unprecedented pace. The sym posium also marked my retirement as Professor and Chairman of the Third Department of Internal Medicine, Hiroshima University School of Medicine, and a new beginning as a Professor of the University of the Air. The symposium was remarkably successful, and there were enthusiastic responses from scientists allover the world, proving that the meeting was timely. The selected papers…mehr
The Third International Symposium on Neurotransmitter Receptors was held in Hiroshima at a time when the entire field of neurotransmitter receptors in the brain is progressing at an unprecedented pace. The sym posium also marked my retirement as Professor and Chairman of the Third Department of Internal Medicine, Hiroshima University School of Medicine, and a new beginning as a Professor of the University of the Air. The symposium was remarkably successful, and there were enthusiastic responses from scientists allover the world, proving that the meeting was timely. The selected papers contained in this volume constitute a state of-the-art survey of the most advanced aspects of neurotransmitter recep tor mechanisms in the brain. lowe thanks for the great success of the symposium to Prof. Richard Olsen of UCLA, Prof. Tomio Segawa of Hiroshima University, Prof. Kinya Kuriyama of Kyoto Prefectural University of Medicine, and Prof. Masaya Tohyama of Osaka University. I express my sincere gratitude to many friends for making this publication possible. I especially thank Dr. Rie Miyoshi, whose devoted efforts as secretary-general were vital to the success of the symposium. Dr. Miyoshi is currently an instructor in the Department of Pharmacology at Tokyo Women's Medical College. I would also like to acknowledge the excellent secretarial work of Misses Ritsuko Sato and Yuko Wakita.
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Effect of Neuropeptides on Classic Types of Neurotransmission in the Rat Central Nervous System.- Solubilization and Characterization of Substance P Receptors in the Central Nervous System.- Evidence for Cardiovascular Roles of Tachykinin Peptides in the Brain of the Rat.- Functions of a Co-Transmitter, Calcitonin Gene-Related Peptide, on the Neuromuscular Junction.- Pharmacological Characterization of Sigma Binding Sites in Guinea Pig Brain Membranes.- Transmitter-Activated Ion Channels as the Target of Chemical Agents.- Chemical Kinetic Investigations of the Channel-Opening Process of Neurotransmitter Receptors.- Primary Structure and Functional Expression of the Inositol 1,4,5-Trisphosphate Receptor, P400.- Inositol 1,4,5-Trisphosphate Activates Ca2+ Channels in the Plasma Membranes of Rat Brain Nerve Terminals.- Formation of Inositol Polyphosphates in Cultured Adrenal Chromaffin Cells.- Effects of Oxygen Depletion on Phosphoinositide Breakdown in Rat Brain Slices.- Expression of G-Protein ?-Subunit cDNA.- Serotonin Receptor Subtypes in Brain: Ligand Binding Properties and Coupling with G Proteins.- A Cerebral Endogenous Factor Regulates the Activity of the Serotonergic Receptors Modulating the Neuronal Release of Acetylcholine.- Serotonin Receptor Heterogeneity and the Role of Potassium Channels in Neuronal Excitability.- Modulatory Actions of Norepinephrine on Neural Circuits.- Genetic Analysis of the ?-Adrenergic Receptor.- Reversal of Nigrostriatal-Lesion-Induced Receptor Alterations by Grafting of Fetal Mesencephalic Dopaminergic Neurons.- Octopamine: An Endogenous Blocker of Dopamine D-1 Receptors.- Depression of NMDA-Evoked Acetylcholine Release by Endogenous Adenosine in Striatum Slices.- Imaging of Dopamine Dl and D2 Receptors by a High Resolution PositronEmission Tomography.- The Nicotinic Acetylcholine Receptor Gene Family: Structure of Nicotinic Receptors from Muscle and Neurons and Neuronal ?-Bungarotoxin-Binding Proteins.- Regulation of the Nicotinic Acetylcholine Receptor by Serine and Tyrosine Protein Kinases.- Affinity Purification of Nicotinic Acetylcholine Receptor from Rat Brain.- Differential Coupling of Subtypes of the Muscarinic Receptor to Signaling Mechanisms in Brain and Peripheral Tissues.- The Molecular Properties of the M1 Muscarinic Receptor and its Regulation of Cytosolic Calcium in a Eukaryotic Gene Expression System.- Molecular Mechanism Underlying the Occurrence of Supersensitivity at Muscarinic Receptors: Analysis Using Cerebral Cortical Neurons in Primary Culture.- Super-Delayed Changes of Muscarinic Acetylcholine Receptor in the Gerbil Hippocampus Following Transient Ischemia.- Intramembrane Particles in the Postsynaptic Membranes of the S-, F-, and C-Type Synapses by Freeze-Fracturing, and Deep-Etching Studies on the Xenopus Spinal Cord.- GABAA -Benzodiazepine Receptors: Demonstration of Pharmacological Subtypes in the Brain.- Structural, Developmental, and Functional Heterogeneity of Rat GABAA Receptors.- Subunit and Subtype-Specific Antibodies to the GABA-A/Benzodiazepine Receptor Complex.- The Differential Expression Pattern of the mRNAs Encoding ? Subunits (?1, ?2 and ?3) of GABAA Receptor in Rat Brain.- "In Vivo" Inhibition of GABAergic Transmission Increases 35S-TBPS Binding in the Rat Brain.- 123-I-Iomazenil-SPECT in Patients with Focal Epilepsies -A Comparative Study with 99mTc-HMPAO-SPECT, CT and MR.- Expression of the GABAB Receptor in Xenopus Oocytes and Desensitization by Activation of Protein Kinase C.- Structure and Expression of Inhibitory Glycine Receptors.-Heterogeneous Distribution of Glutamate Receptor Subtypes in Hippocampus as Revealed by Calcium Fluorometry.- Excitatory Amino Acid Receptors in the Xenopus Oocyte Expression System.- Novel Fourth Binding Sites of [3H]Spermidine within the NMDA Receptor Complex.- Solubilization of the NMDA Receptor Ion Channel Complex from Rat Brain.- NMDA Receptor Agonists: Relationships between Structure and Biological Activity.- Contributors.
Effect of Neuropeptides on Classic Types of Neurotransmission in the Rat Central Nervous System.- Solubilization and Characterization of Substance P Receptors in the Central Nervous System.- Evidence for Cardiovascular Roles of Tachykinin Peptides in the Brain of the Rat.- Functions of a Co-Transmitter, Calcitonin Gene-Related Peptide, on the Neuromuscular Junction.- Pharmacological Characterization of Sigma Binding Sites in Guinea Pig Brain Membranes.- Transmitter-Activated Ion Channels as the Target of Chemical Agents.- Chemical Kinetic Investigations of the Channel-Opening Process of Neurotransmitter Receptors.- Primary Structure and Functional Expression of the Inositol 1,4,5-Trisphosphate Receptor, P400.- Inositol 1,4,5-Trisphosphate Activates Ca2+ Channels in the Plasma Membranes of Rat Brain Nerve Terminals.- Formation of Inositol Polyphosphates in Cultured Adrenal Chromaffin Cells.- Effects of Oxygen Depletion on Phosphoinositide Breakdown in Rat Brain Slices.- Expression of G-Protein ?-Subunit cDNA.- Serotonin Receptor Subtypes in Brain: Ligand Binding Properties and Coupling with G Proteins.- A Cerebral Endogenous Factor Regulates the Activity of the Serotonergic Receptors Modulating the Neuronal Release of Acetylcholine.- Serotonin Receptor Heterogeneity and the Role of Potassium Channels in Neuronal Excitability.- Modulatory Actions of Norepinephrine on Neural Circuits.- Genetic Analysis of the ?-Adrenergic Receptor.- Reversal of Nigrostriatal-Lesion-Induced Receptor Alterations by Grafting of Fetal Mesencephalic Dopaminergic Neurons.- Octopamine: An Endogenous Blocker of Dopamine D-1 Receptors.- Depression of NMDA-Evoked Acetylcholine Release by Endogenous Adenosine in Striatum Slices.- Imaging of Dopamine Dl and D2 Receptors by a High Resolution PositronEmission Tomography.- The Nicotinic Acetylcholine Receptor Gene Family: Structure of Nicotinic Receptors from Muscle and Neurons and Neuronal ?-Bungarotoxin-Binding Proteins.- Regulation of the Nicotinic Acetylcholine Receptor by Serine and Tyrosine Protein Kinases.- Affinity Purification of Nicotinic Acetylcholine Receptor from Rat Brain.- Differential Coupling of Subtypes of the Muscarinic Receptor to Signaling Mechanisms in Brain and Peripheral Tissues.- The Molecular Properties of the M1 Muscarinic Receptor and its Regulation of Cytosolic Calcium in a Eukaryotic Gene Expression System.- Molecular Mechanism Underlying the Occurrence of Supersensitivity at Muscarinic Receptors: Analysis Using Cerebral Cortical Neurons in Primary Culture.- Super-Delayed Changes of Muscarinic Acetylcholine Receptor in the Gerbil Hippocampus Following Transient Ischemia.- Intramembrane Particles in the Postsynaptic Membranes of the S-, F-, and C-Type Synapses by Freeze-Fracturing, and Deep-Etching Studies on the Xenopus Spinal Cord.- GABAA -Benzodiazepine Receptors: Demonstration of Pharmacological Subtypes in the Brain.- Structural, Developmental, and Functional Heterogeneity of Rat GABAA Receptors.- Subunit and Subtype-Specific Antibodies to the GABA-A/Benzodiazepine Receptor Complex.- The Differential Expression Pattern of the mRNAs Encoding ? Subunits (?1, ?2 and ?3) of GABAA Receptor in Rat Brain.- "In Vivo" Inhibition of GABAergic Transmission Increases 35S-TBPS Binding in the Rat Brain.- 123-I-Iomazenil-SPECT in Patients with Focal Epilepsies -A Comparative Study with 99mTc-HMPAO-SPECT, CT and MR.- Expression of the GABAB Receptor in Xenopus Oocytes and Desensitization by Activation of Protein Kinase C.- Structure and Expression of Inhibitory Glycine Receptors.-Heterogeneous Distribution of Glutamate Receptor Subtypes in Hippocampus as Revealed by Calcium Fluorometry.- Excitatory Amino Acid Receptors in the Xenopus Oocyte Expression System.- Novel Fourth Binding Sites of [3H]Spermidine within the NMDA Receptor Complex.- Solubilization of the NMDA Receptor Ion Channel Complex from Rat Brain.- NMDA Receptor Agonists: Relationships between Structure and Biological Activity.- Contributors.
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