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In an unprecedented integration of cutting-edge ideas in immunology with clinical neuropathological findings, Neuroinflammation: Mechanisms and Management reviews and synthesizes our knowledge of the inflammatory mediators and cells involved in neurodegenerative diseases. Beginning with a detailed review of the role of biochemical mediators in neuronal loss and the mechanisms of cell death, the distinguished contributors critically examine research on the design of specific pharmacological agents to inhibit defined points in the neuroinflammatory cascade. They also address the molecular, cellular, and therapeutic actions of first generation agents, as well as their potential clinical relevance to AIDS dementia, Alzheimer's disease, amyotropic lateral sclerosis (ALS), Down's syndrome, Huntington's disease, multiple sclerosis, Parkinson's disease, and stroke. Neuroinflammation: Mechanisms and Management offers a remarkable new synthesis that will play a key role in developingthe molecular targets now emerging in neuropharmacological drug design, and so lead to a new generation of drugs for neurologists to use in the treatment of a wide variety of both acute and chronic neurodegenerative disorders.
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