Neurocircuitry of Addiction (eBook, ePUB)

Redaktion: Gilpin, Nicholas W.

• Format: ePub

Produktbeschreibung

People use drugs for many different reasons, including the pursuit of "high," social factors and self-medication of other conditions. Many millions of people are addicted to at least one substance, and the cost of addiction is immense, at both the individual and societal levels. Neurocircuitry of Addiction is the first book of its kind, with a focus on addiction neuroscience from a neural circuit perspective. This book begins with a primer on circuit-based neuroscience that equips the reader with an understanding of the applications described throughout the book. Each subsequent chapter positions a different brain region at the "center" of addiction neurocircuitry and goes on to describe the anatomical connectivity of that brain region, how those circuits are affected by drug exposure, and the role of those circuits in controlling addiction-related behaviors. All chapters of this book are written by content experts for a target audience that has some basic neuroscience background, but no prior in-depth knowledge regarding the neurocircuitry of addiction.

• Reviews the circuit-based tools that are used by scientists to investigate neural circuit function
• Describes how acute and chronic alcohol and drug exposure affect neural circuit function
• Describes the state of the science regarding the role of specific neural circuis in drug addiction
• Chapters include data from both human neuroscience and animal models

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Produktdetails

• Verlag: Elsevier Science & Techn.
• Seitenzahl: 558
• Erscheinungstermin: 29. November 2022
• Englisch
• ISBN-13: 9780128234549
• Artikelnr.: 66764982

Autorenporträt

Dr Nicholas Gilpin completed his undergraduate training in Psychology at University of Texas at Austin, and his Ph.D. in Psychobiology at Indiana University-Purdue University at Indianapolis. During graduate training, he worked with genetic models of susceptibility to alcoholism. He went on to complete a post-doctoral fellowship in the labs of Drs. George Koob and Marisa Roberto at The Scripps Research Institute in La Jolla, CA, where he used behavioral pharmacology & electrophysiology techniques to explore neural and behavioral dysregulation associated with alcohol dependence. He remains interested in questions of addiction, and is especially interested in understanding why and how alcohol addiction is co-morbid with addiction to other drugs and other psychiatric conditions. His interests also include questions related to subpopulations of addicts and individual differences in propensity to consume alcohol and drugs.

Inhaltsangabe

1. Foreword
2. Leveraging circuits to understand addiction
3. Ventral tegmental area (VTA) circuits
4. Striatal circuits
5. Prefrontal cortical (PFC) circuits
6. Extended amygdala circuits
7. Doral raphe nucleus (5-HT) circuits
8. Locus coeruleus (NE) circuits
9. Neuroendocrine (HPA) circuits
10. Circadian (SCN) circuits