Imran Ali, Hassan Y. Aboul-Enein, Vinod K. Gupta

Nanochromatography and Nanocapillary Electrophoresis (eBook, PDF)

Pharmaceutical and Environmental Analyses

• Format: PDF

Produktbeschreibung

Detection of drugs at low concentration is required in a variety of biological and medical situations, in order to avoid harmful side effects posed by some drug residues. The book details the instrumentation, detection, and application of nano chromatography (that is, any chromatographic and capillary electrophoretic method dealing with the detection of a sample at nano gram per liter or lower) and capillary electrophoresis in the analyses of biological and environmental samples. Methods discussed include: Nano Gas Chromatography, Nano Capillary Electrophoresis, Nano Chiral Chromatography, Micellar Electrokinetic Chromatography, Supercritical Fluid Chromatography, and Nano High Performance Liquid Chromatography.

---

Dieser Download kann aus rechtlichen Gründen nur mit Rechnungsadresse in A, B, BG, CY, CZ, D, DK, EW, E, FIN, F, GR, HR, H, IRL, I, LT, L, LR, M, NL, PL, P, R, S, SLO, SK ausgeliefert werden.

Produktdetails

• Verlag: John Wiley & Sons
• Seitenzahl: 296
• Erscheinungstermin: 2. April 2009
• Englisch
• ISBN-13: 9780470434918
• Artikelnr.: 37292185

Autorenporträt

Imran Ali, PhD, is Associate Professor at the Department of Chemistry, Jamia Millia Islamia (Central University), New Delhi, India. Dr. Ali has published more than 150 scholarly works, including complete books, book and encyclopedia chapters, review articles, research papers, technical reports, and conference presentations. Hassan Y. Aboul-Enein, PhD, is a Professor at Pharmaceutical and Medicinal Chemistry Department, Pharmaceutical and Drug Industries Research Division, National Research Centre, Dokki, Cairo, Egypt. He has published more than 600 articles, including several books and encyclopedia chapters. Vinod K. Gupta is a Professor in the Department of Chemistry, Indian Institute of Technology, Roorkee, India. He has published more than 200 articles including book and encyclopedia chapters, review articles, research papers, technical reports, and conference presentations.

Inhaltsangabe

Chapter 1: Introduction. 1. Nano Analyses. 2. Definition of
Nano-Chromatography and Nano-Capillary Electrophoresis. 3.
Nano-Chromatography and Nano-Capillary Electrophoresis. 4. Fabrication of
Micro Devices. 5. Development in Nano Analyses. 6. Data Integration. 7.
Protocol of Nano Analyses. 8. Scope of the Book. 9. Conclusion. 10.
References. Chapter 2: Fabrication of Micro Chips. 1. Introduction. 2.
Substrates. 3. Techniques of Fabrication. 3.1 Glass Chips. 3.2 Quartz
Chips. 3.3 Silica Chips. 3.4 Polymer Chips. 3.5 Plastic Chips. 3.6 Chips
and PCR. 4. Surface Modification. 4.1 Modification by Polymers. 4.2
Modification by Silica Gel. 4.3 Modification by Monolithics. 4.4
Modification by Sulfonation. 5. Designs of Chips. 6. Bindings of Chips. 7.
Conclusion. 8. References. Chapter 3: Instrumentation of
Nano-Chromatogrpahy and Nano-Capillary Electrophoresis. 1. Introduction. 2.
Nano-Liquid Chromatography. 2.1 Mobile Phase Reservoirs. 2.2 Mobile Phases
and Flow Calibration. 2.3 Mobile Phase Tubings. 2.4 Solvent Delivery Pump.
2.6 Sample Injector. 2.7 Separation Chips. 2.8 Detectors. 2.9 Recorder.
2.10 Sample Preparation Units. 3. Nano Capillary Electrophoresis. 3.1
Separation Chip. 3.2 Background Electrolyte and its Reservoirs. 3.3 Sample
Injection Port. 3.4 Detectors. 3.5 Recorder. 3.6 Sample Preparation Units.
4. Conclusion. 5. References. Chapter 4: Detection in Nano Chromatography
and Nano Capillary Electrophoresis. 1. Introduction. 2. Mass Spectrometer
Detectors. 3. Fluorescence Detectors. 4. Electrochemical Detectors. 5.
Element Specific Detectors. 6. Miscellaneous Detectors. 7. Conclusion. 8.
References. Chapter 5: Sample Preparation in Nano Chromatography and
Nano-Capillary Electrophoresis. 1. Introduction. 2. Sample Preparation. 3.
Sampling. 3.1 Biological Samples. 3.1.1 Blood. 3.1.2 Urine. 3.1.3 Tissues.
3.1.4 Plants. 3.1.5 Food Stuffs. 3.2 Environmental Samples. 3.2.1 Air.
3.2.2 Water. 3.2.3 Sediment and Soils. 4. Preservation. 5. Filtration. 6.
Digestion/Homogenization. 7. Extractions. 8. Clean-Up. 9.
Pre-concentration. 10. Off-Line Nano-Sample Preparation Methods. 10.1 Nano
Solid Phase Extractions. 10.2 Nano Membrane Extractions. 10.3 Nano
Miscellaneous Extractions. 11. On-Line Nano-Sample Preparation Methods. 12.
Conclusion. 13. References. Chapter 6: Nano High Performance Liquid
Chromatography. 1. Introduction. 2. Nano-HPLC. 3. Applications. 3.1
Nano-HPLC of Biological Matrices. 3.1.1 Proteomics. 3.1.2 Drugs Development
and Design. 3.1.3 Environmental Analysis. 4. Optimization of Separations in
Nano-HPLC. 5. Trouble Shooting in Nano-HPLC. 6. Conclusion. 7. References.
Chapter 7: Nano Capillary Electro-Chromatography and Nano Micellar
Electrokinetic Chromatography. 1. Introduction. 2. Nano Capillary
Electro-Chromatography. 2.1 Biological Samples. 2.2 Environmental Samples.
2.3 Mechanism of Separation. 3. Nano Micellar Electrokinetic
Chromatography. 3.1 Biological Samples. 3.2 Environmental Samples. 3.3
Mechanisms of Separation. 4. Conclusion. 5. References. Chapter 8: Nano
Capillary Electrophoresis. 1. Introduction. 2. Optimization. 3.
Applications. 3.1 Proteomics. 3.2 Genomics. 3.3 Amino Acids. 3.4 Drugs
Development and Design. 3.5 Enzymes and Hormones. 3.6 Biological Fluids.
3.7 Foods and Beverages. 3.8 Viruses and Bacteria. 3.9 Explosives. 3.10
Environmental Analyses. 3.11 Miscellaneous Applications. 4. Mechanism of
Separation. 5. Conclusion. 6. References. Chapter 9: Chiral Separations by
Nano Liquid Chromatography and Nano Capillary Electrophoresis. 1.
Introduction. 2. Nano Liquid Chromatography. 3. Nano Capillary
Electrophoresis. 4. Mechanisms of Chiral Separations. 5. Conclusion. 6.
References. Chapter 10: Perspectives of Nano Analyses. 1. Introduction. 2.
Future of Micro Fluidic Devices. 3. Future Challenges. 4. Conclusion. 5.
References.