Muscle Aging, Inclusion-Body Myositis and Myopathies (eBook, ePUB)

Redaktion: Askanas, Valerie; Engel, W. King

• Format: ePub

Produktbeschreibung

Muscle weakness with ageing is almost inevitable, generally beginning to manifest beyond the age of 40, and is usually unstoppable. It can lead to reduced mobility, increased risk of falling, injury, and even death. But "you're just getting old" is not a sufficient diagnosis. Specific causes of neuromuscular symptoms may explain progressive muscle weakness, and should be investigated for potential treatment. Muscle Ageing, Inclusion-Body Myositis and Myopathies explores the clinical and pathological expression of muscle weakness in aging persons. Case studies demonstrate how physicians can more accurately diagnose weakening elderly patients and make better management decisions. It also explores sporadic inclusion-body myositis and hereditary inclusion-body myopathies. The former, the most common progressive muscle disease in the over 50s, is frequently under-diagnosed and, with the increasing population of aged individuals, is presenting a greater challenge. This disease of muscle has pathological similarities with the well-known Alzheimer and Parkinson brain diseases. Edited and written by a leading international cast of authors, Muscle Ageing, Inclusion-Body Myositis and Myopathies provides a state-of-the-art guide to ageing-associated neuromuscular disorders. It should be in the hands of all those involved in the care of aging and muscle-weakened patients. Titles of Related Interest Neuromuscular Disorders Tawil and Vennance (eds); ISBN 978-0-470-65456-9 European Handbook of Neurological Management, Vol 1, 2e Gilhus, Barnes, Brainin (eds); ISBN 978-1-4051-8533-2 European Handbook of Neurological Management, Vol 2, 2e Gilhus, Barnes, Brainin (eds); ISBN 978-1-4051-8534-9

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Produktdetails

• Verlag: John Wiley & Sons
• Seitenzahl: 264
• Erscheinungstermin: 30. November 2011
• Englisch
• ISBN-13: 9781444398298
• Artikelnr.: 38307409

Autorenporträt

Edited by Valerie Askanas, MD, PhD, Departments of Neurology and Pathology, University of Southern California, Keck School of Medicine, CA, USA W. King Engel, MD, Departments of Neurology and Pathology, University of Southern California, Keck School of Medicine, CA, USA

Inhaltsangabe

List of Contributors
vii Preface
xi Part 1 Muscle Aging 1 Aging of the human neuromuscular system: pathological aspects
3 W. King Engel and Valerie Askanas 2 Aging of the human neuromuscular system: clinical considerations
33 W. King Engel and Valerie Askanas 3 Aging of the human neuromuscular system: patient vignettes
55 W. King Engel
Shalini Mahajan
and Valerie Askanas 4 Mitochondrial changes in aging with particular reference to muscle
and possible clinical consequences
81 Salvatore DiMauro
Eric Schon
and Michio Hirano 5 Protein degradation in aging cells and mitochondria: relevance to the neuromuscular system
89 Jenny K. Ngo and Kelvin J. A. Davies 6 Human muscle protein metabolism in relation to exercise and aging: potential therapeutic applications
97 Micah J. Drummond and Blake B. Rasmussen Part 2 Sporadic Inclusion-Body Myositis 7 Pathogenesis of sporadic inclusion-body myositis: role of aging and muscle-fiber degeneration
and accumulation of the same proteins as in Alzheimer and Parkinson brains
111 Valerie Askanas
W. King Engel
and Anna Nogalska 8 Inflammatory and autoimmune features of inclusion-body myositis
146 Marinos C. Dalakas 9 Sporadic inclusion-body myositis: clinical symptoms
physical findings
and diagnostic investigations
159 Frank L. Mastaglia 10 Pathologic diagnostic criteria of sporadic inclusion-body myositis and hereditary inclusion-body myopathy muscle biopsies
168 Valerie Askanas and W. King Engel Part 3 Hereditary Inclusion-Body Myopathies 11 Function and mutations of the GNE gene leading to distal myopathy with rimmed vacuoles/hereditary inclusion-body myopathy
animal models
and potential treatment
177 May Christine V. Malicdan
Satoru Noguchi
and Ichizo Nishino 12 GNE myopathy (hereditary inclusion-body myopathy/distal myopathy with rimmed vacuoles): clinical features and epidemiology
191 Zohar Argov
Ichizo Nishino
and Ikuya Nonaka 13 Consequences of the hereditary inclusion-body myopathy-characteristic GNE mutations on muscle proteins in vivo and in vitro
199 Aldobrando Broccolini and Massimiliano Mirabella 14 Function and structure of VCP mutations leading to inclusion-body myopathy associated with Paget disease of bone and frontotemporal dementia
206 Cezary Wojcik 15 Clinical spectrum of VCP myopathy
Paget disease
and frontotemporal dementia: experimental models and potential treatments
219 Virginia E. Kimonis
Eric Dec
Mallikarjun Badadani
Angele Nalbandian
Jouni Vesa
Vincent Caiozzo
Douglas Wallace
Barbara Martin
Charles Smith
and Giles D. Watts 16 Drosophila and mouse models of hereditary myopathy caused by mutations in VCP/p97
230 Nisha M. Badders and J. Paul Taylor Index
241