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Presents a sampling of new and novel approaches to the amelioration of musculoskeletal disease pathology, emphasizing prevention and therapy. Where applicable, these new technologies are focused on their application to human autoimmune diseases, but the volume mainly discusses and details the use of
Presents a sampling of new and novel approaches to the amelioration of musculoskeletal disease pathology, emphasizing prevention and therapy. Where applicable, these new technologies are focused on their application to human autoimmune diseases, but the volume mainly discusses and details the use of
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Series Introduction Preface 1. Monoclonal Antibodies: New Horizons in the Treatment of Human Autoimmune Disease /William J. Koopman 2. Therapeutic Application of Monoclonal Antibodies in the Rheumatic Diseases /Edward V. Lally 3. Treatment of Patients with Rheumatoid Arthritis with Anti CD4 Monoclonal Antibodies /Christian Herzog, Wolfgang Muller, Christoph Walker, and Werner J. Pichler 4. Human Monoclonal Autoantibodies /Susan Alpert Gale I, Edgar G. Engleman, and Steven K. H. Foung 5. Biologic Therapies for Rheumatoid Arthritis: Concepts from Considerations on Pathogenesis /Ian R. Mackay, Merrill J. Rowley, and Claude C. A. Bernard 6. Cellular and Molecular Interactions in the Induction of Inflammation in Rheumatic Diseases /Sharon M. Wahl 7 Interleukin 1 Inhibitors and Their Significance in Rheumatoid Arthritis /Gloria C. Higgins and Arnold E. Postlethwaite 8. Interleukins and Metalloproteinases in Arthritis /Gene DiPasquale 9. T Cell Cytokines as Immunomodulators of Arthritis Disease Pathology /Thomas F. Kresina and Donna J. Spannaus Martin 10. Induction and Regulation of Arthritis by T Cell Derived Collagen Binding Proteins /David E. Trentham 11. Experimental Arthritis: Importance of T Cells and Antigen Mimicry in Chronicity and Treatment /Wim B. van den Berg, Maries F. van den Broek, Levinus B. A. van de Putte, Mieke C. J. van Bruggen, and Peter L. E. M. van Lent 12. A Mycobacterial 65 kd Heat Shock Protein and T Cells in Experimental Arthritis: Possibilities for Immunotherapy /Willem van Eden, Claire J. P. Boog, Els J. M. Hogervorst, Marca H. M. Wauben, Ruurd van der Zee, and Jan D. A. van Embden 13. Immunotherapy of Collagen Induced Arthritis with Anti la and Anti IL 2R Antibodies /Paul H. Wooley and Subhashis Banerjee 14. Anti L3T4 Antibody Therapy in Systemic Lupus Erythematosus /Nancy L. Carteron and David Wofsy 15. Autoreactive B Cells in Collagen Induced Arthritis /Rikard Holmdahl 16. Antiproteoglycan Antibodies in Experimental Spondylarthritis /Tibor T. Giant, Katalin Mikecz, Edit Buzas, Eric Dayer, and A. Robin Poole 17. Reproduction and Regulation of the Autoimmunity That Induces Cartilage Pathology in Experimental Immune Synovitis /Thomas F. Kresina 18. Serum Keratan Sulfate Concentration as a Measure of the Catabolism of Cartilage Proteoglycans /Eugene J. M. A. Thonar, James M. Williams, M. Barry E. Sweet, Brian A. Maldonado, Mary Ellen Lenz, Thomas J. Schnitzer, Giles V. Campion, and Klaus E. Kuettner 19. Cross Reactive Idiotypes of Rheumatoid Factors in Arthritis and Related Diseases /Pojen P. Chen and Dennis A. Carson 20. Characterization of Rheumatoid Factors Using Monoclonal Anti idiotypic Reagents /Mary Ann Accavitti, Ralph E. Schrohenloher, and William J. Koopman 21. The Human Anti DNA Idiotype (16 /6 Idiotype) /Howard Amital Teplizki and Yehuda Shoenfeld 22. Immunoregulation in Systemic Lupus Erythematosus by Idiotypic Network: Possible Future Therapeutic Implications /Nabih /. Abdou and Ronsuke Suenaga 23. Clinical Trial Design and Concepts for Biologic Agents in the Treatment of Rheumatic Diseases /Vibeke Strand Index.
Series Introduction Preface 1. Monoclonal Antibodies: New Horizons in the Treatment of Human Autoimmune Disease /William J. Koopman 2. Therapeutic Application of Monoclonal Antibodies in the Rheumatic Diseases /Edward V. Lally 3. Treatment of Patients with Rheumatoid Arthritis with Anti CD4 Monoclonal Antibodies /Christian Herzog, Wolfgang Muller, Christoph Walker, and Werner J. Pichler 4. Human Monoclonal Autoantibodies /Susan Alpert Gale I, Edgar G. Engleman, and Steven K. H. Foung 5. Biologic Therapies for Rheumatoid Arthritis: Concepts from Considerations on Pathogenesis /Ian R. Mackay, Merrill J. Rowley, and Claude C. A. Bernard 6. Cellular and Molecular Interactions in the Induction of Inflammation in Rheumatic Diseases /Sharon M. Wahl 7 Interleukin 1 Inhibitors and Their Significance in Rheumatoid Arthritis /Gloria C. Higgins and Arnold E. Postlethwaite 8. Interleukins and Metalloproteinases in Arthritis /Gene DiPasquale 9. T Cell Cytokines as Immunomodulators of Arthritis Disease Pathology /Thomas F. Kresina and Donna J. Spannaus Martin 10. Induction and Regulation of Arthritis by T Cell Derived Collagen Binding Proteins /David E. Trentham 11. Experimental Arthritis: Importance of T Cells and Antigen Mimicry in Chronicity and Treatment /Wim B. van den Berg, Maries F. van den Broek, Levinus B. A. van de Putte, Mieke C. J. van Bruggen, and Peter L. E. M. van Lent 12. A Mycobacterial 65 kd Heat Shock Protein and T Cells in Experimental Arthritis: Possibilities for Immunotherapy /Willem van Eden, Claire J. P. Boog, Els J. M. Hogervorst, Marca H. M. Wauben, Ruurd van der Zee, and Jan D. A. van Embden 13. Immunotherapy of Collagen Induced Arthritis with Anti la and Anti IL 2R Antibodies /Paul H. Wooley and Subhashis Banerjee 14. Anti L3T4 Antibody Therapy in Systemic Lupus Erythematosus /Nancy L. Carteron and David Wofsy 15. Autoreactive B Cells in Collagen Induced Arthritis /Rikard Holmdahl 16. Antiproteoglycan Antibodies in Experimental Spondylarthritis /Tibor T. Giant, Katalin Mikecz, Edit Buzas, Eric Dayer, and A. Robin Poole 17. Reproduction and Regulation of the Autoimmunity That Induces Cartilage Pathology in Experimental Immune Synovitis /Thomas F. Kresina 18. Serum Keratan Sulfate Concentration as a Measure of the Catabolism of Cartilage Proteoglycans /Eugene J. M. A. Thonar, James M. Williams, M. Barry E. Sweet, Brian A. Maldonado, Mary Ellen Lenz, Thomas J. Schnitzer, Giles V. Campion, and Klaus E. Kuettner 19. Cross Reactive Idiotypes of Rheumatoid Factors in Arthritis and Related Diseases /Pojen P. Chen and Dennis A. Carson 20. Characterization of Rheumatoid Factors Using Monoclonal Anti idiotypic Reagents /Mary Ann Accavitti, Ralph E. Schrohenloher, and William J. Koopman 21. The Human Anti DNA Idiotype (16 /6 Idiotype) /Howard Amital Teplizki and Yehuda Shoenfeld 22. Immunoregulation in Systemic Lupus Erythematosus by Idiotypic Network: Possible Future Therapeutic Implications /Nabih /. Abdou and Ronsuke Suenaga 23. Clinical Trial Design and Concepts for Biologic Agents in the Treatment of Rheumatic Diseases /Vibeke Strand Index.
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