Mitochondrial Neuropathies (eBook, ePUB)

• Format: ePub

Produktbeschreibung

Mitochondrial Neuropathies, Volume 146, brings together experts in a range of diseases that damage the nervous system to present the role of mitochondrial dysfunction in their particular field, with this new release focusing on Mitochondrial dysfunction in Alzheimer's Disease, HIV and the mitochondrial: immune interface in the CNS, The Impact of mitochondrial damage in HIV-induced peripheral neuropathy, Mitochondrial dysfunction and the pathogenesis of chemotherapy-induced peripheral neuropathy, Disorders of mitochondrial biogenesis in peripheral neuropathy, Mitochondrial dysfunction and the pathogenesis of diabetic neuropathy, Manipulating mitochondria to treat peripheral neuropathy, and DCA therapy - the yin and yang of mitochondrial activation.

• Contains contributions from a diverse group of experts
• Presents a timely resource that brings together different fields to highlight a common pathogenic mechanism
• Focuses on the role of mitochondria in diverse neuropathies

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Produktdetails

• Verlag: Elsevier Science & Techn.
• Seitenzahl: 252
• Erscheinungstermin: 15. Juni 2019
• Englisch
• ISBN-13: 9780128172254
• Artikelnr.: 56976977

Autorenporträt

Nigel Calcutt, Ph.D. is a Professor in the Department of Pathology at the University of California, San Diego. Dr. Calcutt was spawned and bred in the Black Country of England and took both his B.Sc. in Zoology and Ph.D. Physiology and Pharmacology at Nottingham University, England. Following post-doctoral research at St. Bartholomew's Hospital, London and at the University of California San Diego, he was appointed to the faculty of the Department of Pathology at UCSD in 1993. Dr. Calcutt first began studying nerve damage caused by diabetes as an undergraduate, with a largely unsuccessful, but nevertheless entertaining, attempt to generate diabetic chickens. Undeterred by the paucity of pre-diabetic poultry, he has continued to investigate mechanisms of diabetic neuropathy and neuropathic pain throughout his career, with a particular interest in developing therapies than can be translated to clinical use. He is also a co-founder of the biotechnology company WinSanTor Inc. and

the non-profit organization Diabetes Research Connection.

Inhaltsangabe

1. Mitochondriopathy: The unifying concept in distal neuropathies? Robert E. Schmidt 2. Dysfunction of mitochondria: Implications for Alzheimer's disease Benedict C. Albensi 3. HIV in the cART era and the mitochondrial: immune interface in the CNS Jerel Adam Fields and Ronald J. Ellis 4. Mitochondrial dysfunction in HIV-induced peripheral neuropathy Ricardo H. Roda and Ahmet Hoke 5. Mitochondrial dysfunction in the pathogenesis of chemotherapy-induced peripheral neuropathy Annalisa Trecarichi and Sarah J.L. Flatters 6. Disorders of mitochondrial dynamics in peripheral neuropathy: Clues from hereditary neuropathy and diabetes Amy E. Rumora, Masha G. Savelieff, Stacey A. Sakowski and Eva L. Feldman 7. Role of mitochondria in diabetic peripheral neuropathy: Influencing the NAD⁺-dependent SIRT1-PGC-1a-TFAM pathway Krish Chandrasekaran, Muragundla Anjaneyulu, Joungil Choi, Pranith Kumar, Mohammad Salimian, Cheng-Ying Ho and James W. Russell 8. Dichloroacetate-induced peripheral neuropathy Peter W. Stacpoole, Christopher J. Martyniuk, Margaret O. James and Nigel A. Calcutt