Jane Foster, Gerard Clarke

Microbiota Brain Axis (eBook, ePUB)

A Neuroscience Primer

• Format: ePub

Produktbeschreibung

Microbiota Brain Axis: A Neuroscience Primer provides neuroscience researchers with a comprehensive guide on how to conduct effective microbiota-brain research, understand the appropriate methodologies, and collect and analyze microbiota data. The book begins with an introduction to the importance of the microbiota-brain communication in development and how microbiota impact neurodevelopmental disorders, mental health and neurodegeneration. In addition, the book discusses advances in microbiota analysis tools and techniques for neuroscience related research.

• Reviews the many approaches to manipulating the microbiota in animal studies - including the use of germ-free animals, antibiotics and diet - and covers the strengths and limitations of each
• Outlines available microbiota research tools, such as 16S sequencing and shot-gun metagenomics
• Provides a comprehensive guide to analyzing microbiota-related data and the many choices for bioinformatics

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Produktdetails

• Verlag: Elsevier Science & Techn.
• Seitenzahl: 496
• Erscheinungstermin: 1. März 2024
• Englisch
• ISBN-13: 9780128148013
• Artikelnr.: 70039072

Autorenporträt

Dr. Jane Foster, Ph.D., is a Professor in the Department of Psychiatry, at the Center for Depression Research and Clinical Care at UT Southwestern Medical Center in Dallas, Texas. In the past 20 years, Dr. Foster has developed an internationally recognized translational research program that uses a 'bench to bedside' and back again approach to studying microbiota - brain and immune - brain systems. As one of the early proponents of the role of gut - brain axis in mental health, her lab produced important data demonstrating a role for the microbiome in brain development and behavior in animal studies and recently has extended this work to study the complex neurobiological underpinnings of microbiota - brain and neuroimmune systems in psychiatric illness in clinical populations. Her multidisciplinary expertise includes behavioral neuroscience, molecular biology, immunology, neuroimaging, microbiome, and bioinformatics in both preclinical and clinical research domains. Dr. Foster's research program has developed high-quality analytical pipelines for biological data and novel analytical tools for integrating data across modalities.

Inhaltsangabe

1. The gut-brain axis
2. What is a healthy microbiome?
3. Gene-environment factors influence microbiota composition, diversity,
and function
4. Microbiota to brain communication
5. Microbiota influence behaviour - work in animal models
6. Microbiota influence brain systems - work in animal models
7. Microbiota in neurodevelopmental disorders
8. Microbiota in psychiatry
9. Microbiota-brain interactions in aging and neurodegeneration
10. Pharmacological treatments and the microbiome - Antibiotics and
nonantibiotic drugs
11. Microbial-related treatments
12. Microbiota-related biomarkers for precision medicine and drug discovery