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The immunostimulatory prospects of bacterial DNA have attracted the interest and attention of scientists and physicians and become a major focus in immunobiology and biomedicine. These activities are the product of immunostimulatory DNA sequences (ISS, also known as GpG motifs), which are rare in the mammalian genome. ISS were shown to enhance immunological responses and were used to confer protection to a wide variety of tumors, allergic inflammation, and infections. In Microbial DNA and Host Immunity, leading researchers review the activation of the mammalian immune system by bacterial DNA and consider the applications of ISS in clinical medicine. The authors survey the latest findings concerning the receptor-recognition and signaling pathways triggered by ISS, the process of cell activation, and potential vaccination strategies using ISS. Specific pharmaceutical applications discussed include infectious disease (Hepatitis B, HIV, and mycobacterial infections), allergy (asthma and conjunctivitis), cancer (lymphoma), and inflammation and autoimmunity (arthritis and colitis). Up-to-date and informative, Microbial DNA and Host Immunity illuminates the immunobiology of bacterial DNA and its promise of powerful new vaccines to provide protective immunity against infections, tumors, and chronic disease.
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"I am delighted, therefore to have found this book, which thoroughly reviews the field by contributions from most of the key names associated with the subject. For those not yet initiated into the tell-tale nature of ISS-DNA presented by non-self, the excellent introductory chapter by Eyal Raz(Editor) will reveal all you need to know to read the rest of the book. It summarizes the role of Toll Receptors(TLR) as sensors of infection by recognition of conserved molecular patterns in pathogenic bacteria (PAMPS), a subject very topical these days but riddled with a lot of new reference terms for the poor immunologist to contend with. This new book highlights the fact that even the ubiquitous DNA molecule has been the subject of critical censorship during evolution and has allowed the mammalian innate immune response to use subtle differences between prokaryotic and eukaryotic DNA to inform of bacterial invasion...recommended as an excellent library acquisition, if not a departmental one." -- Immunology News "This is a worthwhile endeavor and the book is of value. Investigators interested in the overall utility of these DNA sequences will find useful material..." -Doody's Health Sciences Book Review Journal