J. G. Salway

Metabolism at a Glance (eBook, PDF)

• Format: PDF

Produktbeschreibung

Metabolism at a Glance presents a concise, illustrated summary of metabolism in health and disease. This essential text is progressively appropriate for introductory through to advanced medical and biochemistry courses. It also provides a succinct review of inborn errors of metabolism, and reference for postgraduate medical practitioners and biomedical scientists who need a resource to quickly refresh their knowledge. Fully updated and extensively illustrated, this new edition of Metabolism at a Glance is now in full colour throughout, and includes new coverage of sports biochemistry; the metabolism of lipids, carbohydrates and cholesterol; glyceroneogenesis, alpha-oxidation and omega-oxidation of fatty acids. It also features the overlooked "Krebs Uric Acid Cycle". Metabolism at a Glance offers an accessible introduction to metabolism, and is ideal as a revision aid for students preparing for undergraduate and USMLE Step 1 exams.

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Produktdetails

• Verlag: John Wiley & Sons
• Seitenzahl: 144
• Erscheinungstermin: 1. Dezember 2016
• Englisch
• ISBN-13: 9781119277781
• Artikelnr.: 47386451

Autorenporträt

Jack Salway was Senior Lecturer within the Faculty of Health and Medical Sciences at the University of Surrey until 2008.

Inhaltsangabe

Preface ix Acknowledgements x Part 1 Energy metabolism 1 Introduction to
metabolic pathways 2 2 Biosynthesis of ATP I: ATP, the molecule that powers
metabolism 4 3 Biosynthesis of ATP II: mitochondrial respiratory chain 6 4
Oxidation of cytosolic NADH: the malate/aspartate shuttle and glycerol
phosphate shuttle 8 5 Metabolism of glucose to provide energy 10 6
Metabolism of one molecule of glucose yields 31 (or should it be 38?)
molecules of ATP 12 7 Anaerobic metabolism of glucose and glycogen to yield
energy as ATP 14 8 2,3-Bisphosphoglycerate (2,3-BPG) and the red blood cell
16 9 Metabolism of triacylglycerol to provide energy as ATP 18 Part 2
Carbohydrate metabolism 10 Metabolism of glucose to glycogen 20 11 Glycogen
metabolism I 22 12 Glycogen metabolism II 24 13 Glycogen metabolism III:
regulation of glycogen breakdown (glycogenolysis) 26 14 Glycogen metabolism
IV: regulation of glycogen synthesis (glycogenesis) 28 15 Pentose phosphate
pathway: the production of NADPH and reduced glutathione 30 16 Regulation
of glycolysis: overview exemplified by glycolysis in cardiac muscle 32 17
Glycolysis in skeletal muscle: biochemistry of sport and exercise 34 18
Regulation of gluconeogenesis 36 19 Regulation of Krebs cycle 38 20 Mammals
cannot synthesize glucose from fatty acids 40 21 Supermouse: overexpression
of cytosolic PEPCK in skeletal muscle causes super-athletic performance 42
22 Sorbitol, galactitol, glucuronate and xylitol 44 23 Fructose metabolism
46 24 Ethanol metabolism 48 Part 3 Fat metabolism 25 Pyruvate/malate cycle
and the production of NADPH 50 26 Metabolism of glucose to fat
(triacylglycerol) 52 27 Metabolism of glucose to fatty acids and
triacylglycerol 54 28 Glycolysis and the pentose phosphate pathway
collaborate in liver to make fat 56 29 Esterification of fatty acids to
triacylglycerol in liver and white adipose tissue 58 30 Mobilization of
fatty acids from adipose tissue I: regulation of lipolysis 60 31
Mobilization of fatty acids from adipose tissue II: triacylglycerol/fatty
acid cycle 62 32 Glyceroneogenesis 64 33 Metabolism of protein to fat after
feeding 66 34 Elongation and desaturation of fatty acids 68 35 Fatty acid
oxidation and the carnitine shuttle 70 36 Ketone bodies 72 37 Ketone body
utilization 74 38 p-Oxidation of unsaturated fatty acids 76 39 Peroxisomal
p-oxidation 78 40 a- and p-oxidation 80 41 co-Oxidation 82 Part 4 Steroid
metabolism 42 Cholesterol 84 43 Steroid hormones and bile salts 86 Part 5
Amino acid metabolism 44 Biosynthesis of the non-essential amino acids 88
45 Catabolism of amino acids I 90 46 Catabolism of amino acids II 92 47
Metabolism of amino acids to glucose in starvation and during the period
immediately after refeeding 94 48 Disorders of amino acid metabolism 96 49
Phenylalanine and tyrosine metabolism 98 50 Tryptophan metabolism: the
biosynthesis of NAD+, serotonin and melatonin 100 51 Ornithine cycle for
the production of urea: the 'urea cycle' 102 Part 6 Metabolic channelling
52 Metabolic channelling I: enzymes are organized to enable channelling of
metabolic intermediates 104 53 Metabolic channelling II: fatty acid
synthase 106 Part 7 Purines, pyrimidines and porphyrins 54 Amino acid
metabolism, folate metabolism and the '1-carbon pool' I: purine
biosynthesis 108 55 Amino acid metabolism, folate metabolism and the
'1-carbon pool' II: pyrimidine biosynthesis 110 56 Krebs uric acid cycle
for the disposal of nitrogenous waste 112 57 Porphyrin metabolism, haem and
the bile pigments 114 Part 8 Integration of metabolic pathways and diabetes
58 Metabolic pathways in fasting liver and their disorder in Reye's
syndrome 116 59 Diabetes I: metabolic changes in diabetes 118 60 Diabetes
II: types I and II diabetes, MODY and pancreatic p-cell metabolism 120 61
Diabetes III: type 2 diabetes and dysfunctional liver metabolism 122 Index
125