Mass Spectrometry of Nucleosides and Nucleic Acids (eBook, PDF)

Redaktion: Banoub, Joseph H.; Limbach, Patrick A.

• Format: PDF

Produktbeschreibung

Assembling the work of an international panel of researchers, this volume summarizes and reviews the latest developments in the field of nucleic acid research by mass spectrometry and provides a window on the next generation of analysis. It highlights the most popular ionization methods and illustrates the diverse strategies used in the characterization and sequencing of novel nucleosides and nucleotides. It also covers deoxyribonucleic acid (DNA), DNA-adducts, DNA-drug complexes, ribonucleic acid (RNA) oligomers of biomedical importance, RNA-protein complexes, and post-transcriptional modifications. The contributions presented in this volume capture the range of these advances, helping to inspire new findings and avenues of research.

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Produktdetails

• Verlag: Taylor & Francis
• Seitenzahl: 504
• Erscheinungstermin: 21. Dezember 2009
• Englisch
• ISBN-13: 9781420044034
• Artikelnr.: 42765801

Autorenporträt

Joseph H. Banoub is a principal scientist and head of the special projects at Fisheries and Oceans Canada, Science Branch. He has been an adjunct professor of biochemistry at Memorial University of Newfoundland since 1984 and an adjunct professor of chemistry since 2006. His present research interests include the uses of tandem mass spectrometry for the structural elucidation of biologically active molecules. Patrick A. Limbach is a professor of chemistry and department head at the University of Cincinnati. His research interests include the development of new mass spectrometry methods for analyzing RNAs, the identification of unknown modified nucleosides, the characterization of RNA-protein complexes, and investigating the role of modified nucleosides in biological systems.

Inhaltsangabe

Overview of Recent Developments in the Mass Spectrometry of Nucleic Acid
and Constituents. Mass Spectrometric Analysis of Deoxyinosines. Tandem Mass
Spectrometry of Nucleic Acids. Mass Spectrometric Application in the Study
of Cyclic Nucleotides in Biochemical Signal Transduction. Analysis of
Urinary Modified Nucleosides by Mass Spectrometry. Mass Spectrometric
Determination of DNA Adducts in Human Carcinogenesis. Sequence Distribution
of Nucleobase Adducts Studied by Isotope Labeling of DNA-Mass Spectrometry.
Electrospray Mass Spectrometry of Noncovalent Complexes between Small
Molecule Ligands and Nucleic Acids. Electrospray Ionization-Mass
Spectrometry for the Investigation of Protein-Nucleic Acid Interactions.
Characterization of Noncovalent Complexes of Nucleic Acids with Peptides
and Proteins by Mass Spectrometry. MALDI-TOF Detection of Specific
Noncovalent Complexes of Highly Acidic Biomolecules with
Pyrenemethylguanidinium. Quantitative Identifi cation of Nucleic Acids via
Signature Digestion Products Detected Using Mass Spectrometry. Electrospray
Ionization Mass Spectrometry for the Direct Analysis of Modified
Nucleosides in Small RNAs. LC-MS/MS for the Examination of the Cytotoxic
and Mutagenic Properties of DNA Lesions. Influence of Metal Ions on the
Structure and Reactivity of Nucleic Acids. Index.