Mass Spectrometry for Drug Discovery and Drug Development (eBook, ePUB)

Redaktion: Korfmacher, Walter A.

• Format: ePub

Produktbeschreibung

Facilitates the discovery and development of new, effective therapeutics With coverage of the latest mass spectrometry technology, this book explains how mass spectrometry can be used to enhance almost all phases of drug discovery and drug development, including new and emerging applications. The book's fifteen chapters have been written by leading pharmaceutical and analytical scientists. Their contributions are based on a thorough review of the current literature as well as their own experience developing new mass spectrometry techniques to improve the ability to discover and develop new and effective therapeutics. Mass Spectrometry for Drug Discovery and Drug Development begins with an overview of the types of mass spectrometers that facilitate drug discovery and development. Next it covers: * HPLC-high-resolution mass spectrometry for quantitative assays * Mass spectrometry for siRNA * Quantitative analysis of peptides * Mass spectrometry analysis of biological drugs * Applications that support medicinal chemistry investigations * Mass spectrometry imaging and profiling Throughout the book, detailed examples underscore the growing role of mass spectrometry throughout the drug discovery and development process. In addition, images of mass spectra are provided to explain how results are interpreted. Extensive references at the end of each chapter guide readers to the primary literature in the field. Mass Spectrometry for Drug Discovery and Drug Development is recommended for readers in pharmaceutics, including medicinal chemists, analytical chemists, and drug metabolism scientists. All readers will discover how mass spectrometry can streamline and advance new drug discovery and development efforts.

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Produktdetails

• Verlag: John Wiley & Sons
• Seitenzahl: 476
• Erscheinungstermin: 12. Dezember 2012
• Englisch
• ISBN-13: 9781118516140
• Artikelnr.: 37758651

Autorenporträt

WALTER A. KORFMACHER, PhD, is Director of Bioanalysis at Genzyme, a Sanofi company, and Associate Editor at the Journal of Mass Spectrometry. Previously, he held positions at the FDA's National Center for Toxicological Research, Schering-Plough Research Institute, Merck Research Laboratories, and Medpace Bioanalytical Laboratories. Dr. Korfmacher is an international leader in developing mass spectrometry techniques and strategies for new drug discovery and drug metabolism applications. A 2009 recipient of the CPSA Distinguished Analytical Scientist Award, he has published more than 150 articles in the scientific literature and made more than eighty presentations at various scientific forums.

Inhaltsangabe

Contributors ix Preface xi 1 Overview of the Various Types of Mass
Spectrometers that are Used in Drug Discovery and Drug Development 1 Gérard
Hopfgartner 2 Utility of High-Resolution Mass Spectrometry for New Drug
Discovery Applications 37 William Bart Emary and Nanyan Rena Zhang 3
Quantitative Mass Spectrometry Considerations in a Regulated Environment 55
Mohammed Jemal and Yuan-Qing Xia 4 Mass Spectrometry for Quantitative In
Vitro ADME Assays 97 Jun Zhang and Wilson Z. Shou 5 Metabolite Identifi
cation Using Mass Spectrometry in Drug Development 115 Natalia Penner,
Joanna Zgoda-Pols, and Chandra Prakash 6 MS Analysis of Biological Drugs,
Proteins, and Peptides 149 Yi Du, John Mehl, and Pavlo Pristatsky 7
Characterization of Impurities and Degradation Products in Small Molecule
Pharmaceuticals and Biologics 191 Hui Wei, Guodong Chen, and Adrienne A.
Tymiak 8 Liquid Extraction Surface Analysis (LESA): A New Mass
Spectrometry-Based Technique for Ambient Surface Profiling 221 Daniel Eikel
and Jack D. Henion 9 MS Applications in Support of Medicinal Chemistry
Sciences 239 Maarten Honing, Benno Ingelse, and Birendra N. Pramanik 10
Imaging Mass Spectrometry of Proteins and Peptides 277 Michelle L. Reyzer
and Richard M. Caprioli 11 Imaging Mass Spectrometry for Drugs and
Metabolites 303 Stacey R. Oppenheimer 12 Screening Reactive Metabolites:
Role of Liquid Chromatography-High-Resolution Mass Spectrometry in
Combination with "Intelligent" Data Mining Tools 339 Shuguang Ma and Swapan
K. Chowdhury 13 Mass Spectrometry of siRNA 357 Mark T. Cancilla and W.
Michael Flanagan 14 Mass Spectrometry for Metabolomics 387 Petia Shipkova
and Michael D. Reily 15 Quantitative Analysis of Peptides with Mass
Spectrometry: Selected Reaction Monitoring or High-Resolution Full Scan?
403 Lieve Dillen and Filip Cuyckens Index 427