Edmond De Hoffmann, Vincent Stroobant

Mass Spectrometry (eBook, PDF)

Principles and Applications

• Format: PDF

Produktbeschreibung

The latest edition of a highly successful textbook, Mass Spectrometry, Third Edition provides students with a complete overview of the principles, theories and key applications of modern mass spectrometry. All instrumental aspects of mass spectrometry are clearly and concisely described: sources, analysers and detectors. Tandem mass spectrometry is introduced early on and then developed in more detail in a later chapter. Emphasis is placed throughout the text on optimal utilisation conditions. Various fragmentation patterns are described together with analytical information that derives from the mass spectra. This new edition has been thoroughly revised and updated and has been redesigned to give the book a more contemporary look. As with previous editions it contains numerous examples, references and a series of exercises of increasing difficulty to encourage student understanding. Updates include: Increased coverage of MALDI and ESI, more detailed description of time of flight spectrometers, new material on isotope ratio mass spectrometry, and an expanded range of applications. Mass Spectrometry, Third Edition is an invaluable resource for all undergraduate and postgraduate students using this technique in departments of chemistry, biochemistry, medicine, pharmacology, agriculture, material science and food science. It is also of interest for researchers looking for an overview of the latest techniques and developments.

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Produktdetails

• Verlag: John Wiley & Sons
• Seitenzahl: 502
• Erscheinungstermin: 22. Oktober 2007
• Englisch
• ISBN-13: 9780470512135
• Artikelnr.: 37293379

Autorenporträt

Edmond de Hoffmann, Université Catholique de Louvain, Belgium & Ludwig Institute for Cancer Research, Brussels, Belgium. Vincent Stroobant, Ludwig Institute for Cancer Research, Brussels, Belgium.

Inhaltsangabe

Contents Preface Introduction Principles Diagram of a Mass Spectrometer
History Ion Free Path 1 Ion Sources 1.1 Electron Ionization 1.2 Chemical
Ionization 1.3 Field Ionization 1.4 Fast Atom Bombardment and Liquid
Secondary Ion Mass Spectrometry 1.5 Field Desorption 1.6 Plasma Desorption
1.7 Laser Desorption 1.8 Matrix-Assisted Laser Desorption Ionization 1.9
Thermospray 1.10 Atmospheric Pressure Ionization 1.11 Electrospray 1.12
Atmospheric Pressure Chemical Ionization 1.13 Atmospheric Pressure
Photoionization (APPI) 1.14 Atmospheric Pressure Secondary Ion Mass
Spectrometry (APSIMS) 1.15 Inorganic Ionization Sources 1.16 Gas-Phase
Ion-Molecule Reactions 1.17 Formation and Fragmentation of Ions: Basic
Rules 2 Mass Analyzers 2.1 Quadrupole Analyzers 2.2 Ion Trap Analyzers 2.3
The Electrostatic Trap or "Orbitrap" 2.4 Time-of-Flight Analyzers 2.5
Magnetic and Electromagnetic Analyzers 2.6 Ion Cyclotron Resonance and
Fourier Transform Mass Spectrometry 2.7 Hybrid Instruments 3 Detectors and
Computers 3.1 Detectors 3.2 Computers 4 Tandem Mass Spectrometry (MS/MS)
4.1 Tandem Mass Spectrometry in Space or in Time 4.2 Tandem Mass
Spectrometry Scan Modes 4.3 Collision-activated or Collision-induced
Dissociation (CAD or CID) 4.4 Other Methods of Ion Activation 4.5 Reactions
Studied in MS/MS 4.6 Tandem Mass Spectrometry Applications 5 Mass
Spectrometry/Chromatography Coupling 5.1 Elution Chromatography Coupling
Techniques 5.2 Chromatography Data Acquisition Modes 5.3 Data Recording and
Treatment 6 Analytical Information 6.1 Mass Spectrometry Spectral
Collections 6.2 High Resolution 6.3 Isotopic Abundances 6.4 Low-mass
Fragments and Lost Neutrals 6.5 Number of Rings or Unsaturations 6.6 Mass
and Electron Parities, Closed-shell Ions and Open-shell Ions 6.7
Quantitative Data 7 Fragmentation Reactions 7.1 Electron Ionization and
Fragmentation Rates 7.2 Quasi-equilibrium and RRKM Theory 7.3 Ionization
and Appearance Energies 7.4 Fragmentation Reactions of Positive Ions 7.5
Fragmentation Reactions of Negative Ions 7.6 Charge Remote Fragmentation
(CRF) 7.7 Spectrum Interpretation 8 Analysis of Biomolecules 8.1
Biomolecules and Mass Spectrometry 8.2 Proteins and Peptides 8.3.
Oligonucleotides 8.4. Oligosaccharides 8.5. Lipids 8.6 Metabolomics 9
Exercises A. Questions B. Answers Appendices Appendix 1. Nomenclature 1.1.
Units 1.2. Definitions 1.3. Analyzers 1.4. Detection 1.5. Ionization 1.6
Ion Types 1.7. Ion-molecule Reaction 1.8. Fragmentation Appendix 2.
Abbreviations Appendix 3. Fundamental Physical Constants Appendix 4A .
Table of Isotopes in Ascending Mass Order Appendix 4B. Table of Isotopes in
Alphabetical Order Appendix 5. Isotopic Abundances in % for Various
Elemental Compositions CHON (M = 100%) Appendix 6. Gas-Phase Ion
Thermochemical Data of Molecules Appendix 7. Gas-Phase Ion Thermochemical
Data of Radicals Appendix 8. Literature on Mass Spectrometry Appendix 9.
Mass Spectrometry on Internet Index

Rezensionen

"This is a great book for everyone in the field to keep handy." (CHOICE, April 2008)

"Overview of the principles, theories, and key applications of modern mass spectrometry." (Materials and Corrosion, November 2007)