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Acute Coronary Syndrome covers the spectrum of clinical conditions ranging from unstable angina to non-ST elevation myocardial infarction and ST elevation myocardial infarction. These life-threatening disorders are a major cause of emergency medical care, hospitalization and mortality. Management of Acute Coronary Syndromes is designed to provide busy clinicians with a comprehensive guide to the investigation, diagnosis and treatment of these syndromes. It encompasses the latest technologies, including the use of biomarkers and non-invasive imaging procedures. For each condition, the reader is…mehr
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- Produktdetails
- Verlag: John Wiley & Sons
- Seitenzahl: 238
- Erscheinungstermin: 30. März 2009
- Englisch
- ISBN-13: 9780470745458
- Artikelnr.: 37298952
- Verlag: John Wiley & Sons
- Seitenzahl: 238
- Erscheinungstermin: 30. März 2009
- Englisch
- ISBN-13: 9780470745458
- Artikelnr.: 37298952
Pathophysiology of acute coronary syndromes (Alisa B. Rosen and Eli V.
Gelfand). Introduction. Formation of atherosclerotic plaque. Plaque
instability and the development of ACS. Myocardial ischemia. Thrombus
formation. Platelets. Secondary hemostasis. Dynamic obstruction.
Progressive mechanical obstruction. Inflammation. Secondary unstable
angina. References. Chapter 2 Diagnosis of acute coronary syndrome (Eli V.
Gelfand and Alisa B. Rosen). Introduction. Definition of myocardial
infarction. History. Risk factors. Physical examination.
Electrocardiography. The pathophysiologic basis of ST segment changes
during ischemia. Electrocardiography in ST-elevation MI and identification
of the infarct-related artery. Electrocardiography in unstable angina and
Cardiac biomarkers. Noninvasive imaging. Echocardiography. Myocardial
perfusion imaging. Coronary computed tomography. Cardiovascular magnetic
resonance imaging. Stress testing for diagnosis of ACS. Overall diagnostic
pathway for ACS. References. Chapter 3 Unstable angina and non-ST-elevation
myocardial infarction(Eli V. Gelfand and Christopher P. Cannon).
Introduction. Causes of UA/NSTEMI. Presentation of UA/NSTEMI. General
strategies in management of UA/NSTEMI. Risk stratification of patients with
UA/NSTEMI. Initial management of UA/NSTEMI in the emergency department.
Pharmacologic treatment of ischemia in UA/NSTEMI. Beta-blockers. Nitrates.
Calcium channel blockers. Angiotensin-converting enzyme inhibitors.
Morphine. Oxygen. Invasive versus conservative strategy. Antiplatelet
therapy in UA/NSTEMI. Aspirin. Clopidogrel. Prasugrel. Glycoprotein
IIb/IIIa inhibitors. Anticoagulant therapy in UA/NSTEMI. Unfractionated
heparin. Enoxaparin. Direct thrombin inhibitors. Fondaparinux. Oral
anticoagulation in UA/NSTEMI. Fibrinolysis in UA/NSTEMI. Early
lipid-lowering therapy in patients with UA/NSTEMI. Predischarge noninvasive
risk stratification after UA/NSTEMI. Overall management of UA/NSTEMI.
References. Chapter 4 ST-segment-elevation myocardial infarction (Eli V.
Gelfand and Christopher P. Cannon). Introduction. Global treatment goals in
STEMI. Prehospital management and triage. Transport decisions. Management
prior to reperfusion. Primary reperfusion therapy for STEMI. Fibrinolysis.
Combination fibrinolysis. Markers of fibrinolysis effectiveness.
Complications of fibrinolysis. Primary percutaneous coronary intervention.
Comparison of PCI with fibrinolysis. Timing of primary PCI. PCI following
fibrinolytic therapy. Rescue PCI. Facilitated PCI. Routine PCI after
successful fibrinolysis. Overall reperfusion strategy. Coronary artery
bypass grafting for treatment of STEMI. Adjunctive pharmacologic treatment
of STEMI. Antiplatelet agents. Anticoagulation therapy. Other adjunctive
therapy. Hospital care following successful reperfusion. References.
Chapter 5 Special considerations in acute coronary syndromes (Jason Ryan
and Eli V. Gelfand). Secondary unstable angina. Acute coronary syndrome in
patients with diabetes mellitus. General considerations. Primary ACS
therapy in diabetics. Glycemic control in diabetics with ACS. Coronary
revascularization in diabetics. Metabolic syndrome and ACS. Chronic kidney
disease in ACS. Young patients with ACS. ACS in the setting of cocaine use.
ACS in patients with normal coronary arteries or mild CAD. Myocarditis.
Acute transient apical ballooning syndrome. Postoperative ACS. ACS in a
pregnant woman. Hyperthyroidism and ACS. ACS in patients exposed to
radiation. Trauma and ACS. References. Chapter 6 Complications of acute
coronary syndrome (Jan M. Pattanayak and Eli V. Gelfand). Introduction.
Pump failure. General principle. Clinical presentation. Prognosis.
Treatment. Right ventricular infarction. Introduction. Clinical
presentation. Diagnosis. Management. Prognosis. Mechanical complications of
ACS. Introduction. Left ventricular free wall rupture. Ventricular septal
rupture. Acute mitral regurgitation. Left ventricular aneurysm. Left
ventricular pseudoaneurysm. Pericardial complications. Arrhythmic
complications of ACS. Bradyarrhythmias. Atrial fibrillation. Ventricular
tachycardia and fibrillation. Complications involving bleeding.
Complications of percutaneous coronary intervention. References. Chapter 7
Post-hospitalization care of patients with acute coronary syndrome (Jersey
Chen and Eli V. Gelfand). Introduction. Pharmacologic measures. Aspirin.
Clopidogrel. Beta adrenergic blockade. Renin-angiotensin-aldosterone
inhibitors. Lipid-lowering therapy. Warfarin. Influenza vaccination.
Medications of limited benefit to patients following ACS.
Vitamins/antioxidants. Estrogen replacement therapy. Nonsteroidal
anti-inflammatory agents and related compounds. Nonpharmacologic measures.
Antiarrhythmic devices. Therapy of comorbidities following ACS. Diabetes
mellitus. Hypertension. Depression. Lifestyle recommendations following
ACS. General physical activity and structured cardiac rehabilitation.
Sexual activity after ACS. Smoking cessation. Diet/nutrition and weight
loss. References. Appendix. Index.
Pathophysiology of acute coronary syndromes (Alisa B. Rosen and Eli V.
Gelfand). Introduction. Formation of atherosclerotic plaque. Plaque
instability and the development of ACS. Myocardial ischemia. Thrombus
formation. Platelets. Secondary hemostasis. Dynamic obstruction.
Progressive mechanical obstruction. Inflammation. Secondary unstable
angina. References. Chapter 2 Diagnosis of acute coronary syndrome (Eli V.
Gelfand and Alisa B. Rosen). Introduction. Definition of myocardial
infarction. History. Risk factors. Physical examination.
Electrocardiography. The pathophysiologic basis of ST segment changes
during ischemia. Electrocardiography in ST-elevation MI and identification
of the infarct-related artery. Electrocardiography in unstable angina and
Cardiac biomarkers. Noninvasive imaging. Echocardiography. Myocardial
perfusion imaging. Coronary computed tomography. Cardiovascular magnetic
resonance imaging. Stress testing for diagnosis of ACS. Overall diagnostic
pathway for ACS. References. Chapter 3 Unstable angina and non-ST-elevation
myocardial infarction(Eli V. Gelfand and Christopher P. Cannon).
Introduction. Causes of UA/NSTEMI. Presentation of UA/NSTEMI. General
strategies in management of UA/NSTEMI. Risk stratification of patients with
UA/NSTEMI. Initial management of UA/NSTEMI in the emergency department.
Pharmacologic treatment of ischemia in UA/NSTEMI. Beta-blockers. Nitrates.
Calcium channel blockers. Angiotensin-converting enzyme inhibitors.
Morphine. Oxygen. Invasive versus conservative strategy. Antiplatelet
therapy in UA/NSTEMI. Aspirin. Clopidogrel. Prasugrel. Glycoprotein
IIb/IIIa inhibitors. Anticoagulant therapy in UA/NSTEMI. Unfractionated
heparin. Enoxaparin. Direct thrombin inhibitors. Fondaparinux. Oral
anticoagulation in UA/NSTEMI. Fibrinolysis in UA/NSTEMI. Early
lipid-lowering therapy in patients with UA/NSTEMI. Predischarge noninvasive
risk stratification after UA/NSTEMI. Overall management of UA/NSTEMI.
References. Chapter 4 ST-segment-elevation myocardial infarction (Eli V.
Gelfand and Christopher P. Cannon). Introduction. Global treatment goals in
STEMI. Prehospital management and triage. Transport decisions. Management
prior to reperfusion. Primary reperfusion therapy for STEMI. Fibrinolysis.
Combination fibrinolysis. Markers of fibrinolysis effectiveness.
Complications of fibrinolysis. Primary percutaneous coronary intervention.
Comparison of PCI with fibrinolysis. Timing of primary PCI. PCI following
fibrinolytic therapy. Rescue PCI. Facilitated PCI. Routine PCI after
successful fibrinolysis. Overall reperfusion strategy. Coronary artery
bypass grafting for treatment of STEMI. Adjunctive pharmacologic treatment
of STEMI. Antiplatelet agents. Anticoagulation therapy. Other adjunctive
therapy. Hospital care following successful reperfusion. References.
Chapter 5 Special considerations in acute coronary syndromes (Jason Ryan
and Eli V. Gelfand). Secondary unstable angina. Acute coronary syndrome in
patients with diabetes mellitus. General considerations. Primary ACS
therapy in diabetics. Glycemic control in diabetics with ACS. Coronary
revascularization in diabetics. Metabolic syndrome and ACS. Chronic kidney
disease in ACS. Young patients with ACS. ACS in the setting of cocaine use.
ACS in patients with normal coronary arteries or mild CAD. Myocarditis.
Acute transient apical ballooning syndrome. Postoperative ACS. ACS in a
pregnant woman. Hyperthyroidism and ACS. ACS in patients exposed to
radiation. Trauma and ACS. References. Chapter 6 Complications of acute
coronary syndrome (Jan M. Pattanayak and Eli V. Gelfand). Introduction.
Pump failure. General principle. Clinical presentation. Prognosis.
Treatment. Right ventricular infarction. Introduction. Clinical
presentation. Diagnosis. Management. Prognosis. Mechanical complications of
ACS. Introduction. Left ventricular free wall rupture. Ventricular septal
rupture. Acute mitral regurgitation. Left ventricular aneurysm. Left
ventricular pseudoaneurysm. Pericardial complications. Arrhythmic
complications of ACS. Bradyarrhythmias. Atrial fibrillation. Ventricular
tachycardia and fibrillation. Complications involving bleeding.
Complications of percutaneous coronary intervention. References. Chapter 7
Post-hospitalization care of patients with acute coronary syndrome (Jersey
Chen and Eli V. Gelfand). Introduction. Pharmacologic measures. Aspirin.
Clopidogrel. Beta adrenergic blockade. Renin-angiotensin-aldosterone
inhibitors. Lipid-lowering therapy. Warfarin. Influenza vaccination.
Medications of limited benefit to patients following ACS.
Vitamins/antioxidants. Estrogen replacement therapy. Nonsteroidal
anti-inflammatory agents and related compounds. Nonpharmacologic measures.
Antiarrhythmic devices. Therapy of comorbidities following ACS. Diabetes
mellitus. Hypertension. Depression. Lifestyle recommendations following
ACS. General physical activity and structured cardiac rehabilitation.
Sexual activity after ACS. Smoking cessation. Diet/nutrition and weight
loss. References. Appendix. Index.