Jeffrey K. Actor

Introductory Immunology (eBook, ePUB)

Basic Concepts for Interdisciplinary Applications

• Format: ePub

Produktbeschreibung

Introductory Immunology: Basic Concepts for Interdisciplinary Applications, 3rd Edition, is a completely updated, revised, and expanded concise, conceptual approach to understanding the immune systems as a primary defense to maintain health and homeostasis. This expanded version includes the aspects of microbiology and related immune defense mechanisms important in combating disease, as well critical components related to the field of vaccine development.

Immunology as a subject is no longer confined to the realms of "immunology" or "microbiology" studies. Indeed, the subject matter has become increasingly important to understand complex mechanisms found within a wider range of biological systems. This book aims specifically at educated audiences who do not have a deep understanding of medical, biochemical, or cellular knowledge. The overall text will present concepts that portray a comprehensive picture of the natural defenses to infectious agents as well as provide an introduction to mechanisms that lead to autoimmune dysfunction. In addition, immunological diseases will be detailed, with the goal of allowing the readers to gain sufficient knowledge to make sound choices for clinical decisions to affect treatment outcomes.

This new edition expands on the existing chapters, focusing on updating the previous text. It has been expanded to include knowledge on effector mechanisms addressing components inherent within cellular responses that are either newly discovered, or missing from the previous edition. It has an extra emphasis on aspects related to mechanisms important in combating microbial agents and critical sections on how vaccines protect against pathogenic invaders to limit associated pathology.

The goal is that Introductory Immunology will become the preferred provider of core knowledge in immunology to build a foundation to explore components of the human immune system that work together to confer and understand dysregulation that causes clinical diseases. This book serves as a basic platform to define therapeutic interventions by:

• creating appreciation for components of the human immune system to work together to confer lifelong protection;
• providing a core knowledge in immunology to build a foundation to explore mechanisms involved in clinical disease, and defining functional aspects of immunological terms to permit the reader easy access to comprehend specific topics;
• presenting introduction to complex immunological concepts in a concise and easy manner that relates to clinical disease;
• breaking down all of immunology into manageable, logically digestible building blocks, and providing a map to explore overlapping mechanisms of immune protective responses;
• providing a platform to readers without medical, biochemical, or cellular expertise to understand and appreciate how immunology controls homeostasis and protects against pathogens.

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Produktdetails

• Verlag: Elsevier Science & Techn.
• Seitenzahl: 224
• Erscheinungstermin: 2. Februar 2023
• Englisch
• ISBN-13: 9780443153082
• Artikelnr.: 67394873

Autorenporträt

Jeffrey K. Actor, PhD, is a professor and Medical Immunology Course Director in the Department of Pathology and Laboratory Medicine at the McGovern Medical School at the University of Texas Health Center at Houston. Dr. Actor received his PhD degree from the University of Massachusetts. His research interests include examination of host immune responses during pathogenic disease, understanding proinflammatory and regulatory cytokines during mycobacterial infections, vaccine development, and molecular mechanisms of adjuvant-induced immunomodulation.

Professor Actor has established himself as a productive educator-scientist with a strong background in immunology and molecular biology with a broad range of expertise in pathobiology. He has shown his commitment to education and excellence, at both the Medical School and Graduate School levels.

Inhaltsangabe

Preface Acknowledgments
1. A functional overview of the immune system and components Chapter focus
Immune homeostasis Self versus nonself Innate and adaptive immunity Anatomy
of the immune system Cells of the immune system First-line defenders: the
myeloid cells Adaptive avengers: the lymphoid cells Lymphocytes Cluster of
differentiation Summary
2. The inflammatory response Chapter focus Inflammation Initiation of the
inflammatory response The role of antibodies in inflammation Biological
functions of complement Activation and directed migration of leukocytes
Pathogen recognition and cytokine signaling Feedback and adaptation from a
distance Pathological consequences of the inflammatory Response Summary
3. The B lymphocyte: antibodies and how they function Chapter focus B
lymphocytes produce antibodies Structural characteristics of
immunoglobulins Immunoglobulin nomenclature Biologic properties of antibody
isotypes IgD IgM IgG IgA IgE Kinetics of antibody response Membrane-bound
immunoglobulin Development of B cells Antibody gene recombination
Development and selection of mature B cells Activation and differentiation
of B cells Summary
4. T lymphocytes: ringleaders of adaptive immune function Chapter focus T
lymphocytes: specific and long-lasting immunity The T cell receptor T-cell
development Antigen recognition by T cells: requirement of major
histocompatibility molecules The HLA locus MHC class I MHC class II T
lymphocyte functions CD4 1 T-helper cells Events involved in T lymphocyte
activation Role of T cells in B-cell activation Cytotoxic T-cell effectors
CD8 1 T cells Other lymphocyte phenotypes ?d T cells Innate lymphocytes
Natural killer T (NKT) cells Superantigens Summary
5. How we defend against infectious agents Chapter focus Immune homeostasis
and pathogenic organisms Major immune defense mechanisms against pathogens
Physical barriers to infection Anatomic barrier Physiological barrier
Phagocytic and endocytic barriers Inflammatory barriers Bacterial
infections Microbial motifs detected through pattern-recognition receptors
Mycobacterial infections Viral infections Human immunodeficiency virus
Parasitic infections (helminths) Fungal infections Evasion of immune
response Summary
6. Basic disorders of immune function Chapter focus Immunodeficiency
disorders Genetic basis for primary immunodeficiency Innate deficiencies
Chronic granulomatous disease/myeloperoxidase deficiency Leukocyte adhesion
deficiency Chediakreceptor disorders Adaptive immune disorders X-linked agammaglobulinemia
Selective immunoglobulin A deficiency Common variable immunodeficiency
Hyper immunoglobulin M disorders DiGeorge syndrome WiskottSevere combined immunodeficiency Treatment of immunodeficiency diseases
Immunodeficiency as a predisposition to disease Human immunodeficiency
virus and acquired immunodeficiency syndrome Summary
7. Autoimmunity: regulation of response to self Chapter focus Homeostasis,
immune regulation, and autoimmunity Tolerance to self Etiology of
autoimmune disease Role of autoantibodies and self-reactive T lymphocytes
in autoimmune disorders Laboratory tests for autoimmunity Targeted
therapeutics Summary
8. Immune hypersensitivities Chapter focus Hypersensitive disorders Type I
hypersensitivity: immunoglobulin Ehypersensitivity: antibody-mediated cytotoxic hypersensitivity Type III
hypersensitivity: immune complex-mediated hypersensitivity Type IV
hypersensitivity: delayed-type (cell-mediated) hypersensitivity Alternative
hypersensitivity classifications Summary
9. Vaccines and immunotherapy Chapter focus Principles of vaccination Basic
concepts of protective immunization Types of immunizations Age and timing
of immunizations Vaccine types and components Immunologic adjuvants Passive
immunization Therapeutic uses of immunoglobulins Other ways to modify
immunity Summary
10. Cancer immunology Chapter focus Understanding immune defenses against
cancers Tumor antigens Effector mechanisms in tumor immunity Natural killer
cells and innate response to tumor cells Adaptive response to tumor cells
Escape mechanisms of tumor elimination Tumors of the immune system
Immunodiagnosis and immunotherapy Summary
11. Transplantation immunology Chapter focus Transplantation defined Tissue
histocompatibility Natural isohemagglutinins Human leukocyte antigens
Allograft rejection Hyperacute rejection Accelerated rejection Acute
rejection Chronic rejection Graft-versus-host disease Pretransplantation
histocompatibility evaluation Immunosuppressive drugs to prevent allograft
rejection Immunosuppressive therapy Summary
12. Assessment of immune parameters and immunodiagnostics Chapter focus
Antibodyantibodyimmunodiffusion The Ouchterlony assay Immunoelectrophoresis Latex
agglutination Lateral flow Western blot Immunoassays Enzyme-linked
immunoadsorbent assay Detection of cellular antigens Immunohistochemistry
Fluorescence-activated cell sorting analysis Multiplex bead arrays Assays
to determine immune function Complement fixation test Phagocyte function
assays Lymphocyte function assays Other tools to measure immunological
status Monoclonal antibodies Microarrays Summary Glossary Index