Insertional Mutagenesis Strategies in Cancer Genetics (eBook, PDF)

Redaktion: Dupuy, Adam J.; Largaespada, David A.

• Format: PDF

Produktbeschreibung

Over the past decades, insertional mutagenesis has played an important contribution to our understanding of cancer. Initially, the action of slow transforming retroviruses was used to identify endogenous cellular oncogenes (e.g. Myc, Myb). These observations sparked a series of experiments that eventually led to the idea cancer is caused by somatically acquired mutations in endogenous oncogenes and tumor suppressor genes. Since these discoveries, insertional mutagenesis has been used to identify novel cancer genes in a variety of tumor types in animal models of cancer. More recent work has developed novel insertional mutagens, such as transposons, that have broader capabilities to model cancer in vivo. While this work has focused on developing animal models of cancer, recent gene therapy trials in human patients have shown that insertional mutagenesis can also contribute to transformation. The goal of this work is summarize the contribution that insertional mutagenesis has made to our understanding of cancer. A variety of insertional mutagens are presented that have been used to study a variety of tumor types in several model organisms. In addition, the impact of insertional mutagenesis in several gene therapy trials is discussed along with strategies to avoid such complications in future clinical trials.

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Produktdetails

• Verlag: Springer-Verlag GmbH
• Seitenzahl: 200
• Erscheinungstermin: 18. November 2010
• Englisch
• ISBN-13: 9781441976567
• Artikelnr.: 37356442

Autorenporträt

Adam Dupuy, Ph.D., is an Assistant Professor at the Carver College of Medicine at the University of Iowa, and a rising star in the field of insertional mutagenesis; two of the last of his publications have been in Nature, and he was the lead author on one of these. Dr. Dupuy earned his B.A. at Central College in Pella, Iowar, went on to earn his Ph.D. at the University of Minnesota in the Program in Molecular, Cellular, Developmental Biology & Genetics, and did his Postdoctoral fellowship in the Mouse Cancer Genetics Program at the NCI-Frederick.

Inhaltsangabe

Chapter 1:IntroductionAuthor: Anton Berns (Netherlands Cancer Institute)Chapter 2:Retroviral mutagenesis in mouse leukemia/lymphomaAuthor: David Largaespada, Ph.D. (University of Minnesota)Chapter 3:MMTV models of breast cancerAuthor: John Hilkens (NKI)Chapter 4:Retroviral mutagenesis in other organismsAuthor: Michael Dvorak (Inst. Of Molecular Genetics, Prague, Czech Rep.)Chapter 5:Sleeping Beauty models of cancerAuthor: Adam J. Dupuy, Ph.D. (University of Iowa)Chapter 6:Insertional mutagenesis in gene therapy patientsAuthor: David Williams, M.D. (Cincinnati Children's Hospital)Chapter 7:Bioinformatics of high throughput insertional mutagenesisAuthor: Keiko Akagi (NCI-Frederick)