Immunotherapy in Translational Cancer Research (eBook, ePUB)

Redaktion: Cooper, Laurence J. N.; Prabhakaran, Sabitha; Moyes, Judy; Mittendorf, Elizabeth A.

• Format: ePub

Produktbeschreibung

A guide to state-of-the-art cancer immunotherapy in translational cancer research A volume in the Translational Oncology series, Immunotherapy in Translational Cancer Research explores the recent developments in the role that immunotherapy plays in the treatment of a wide range of cancers. The editors present key concepts, illustrative examples, and suggest alternative strategies in order to achieve individualized targeted therapy. Comprehensive in scope, Immunotherapy in Translational Cancer Research reviews the relevant history, current state, and the future of burgeoning cancer-fighting therapies. The book also includes critical information on drug development, clinical trials, and governmental resources and regulatory issues. Each chapter is created to feature: development of the immunotherapy; challenges that have been overcome in order to scale up and undertake clinical trials; and clinical experience and application of research. This authoritative volume is edited by a team of noted experts from MD Anderson Cancer Center, the world's foremost cancer research and care center and: * Offers a comprehensive presentation of state-of-the-art cancer immunotherapy research that accelerates the pace of clinical cancer care * Filled with the concepts, examples, and approaches for developing individualized therapy * Explores the breath of treatments that reflect the complexity of the immune system itself * Includes contributions from a panel international experts in the field of immunotherapy Designed for physicians, medical students, scientists, pharmaceutical executives, public health and public policy government leaders and community oncologists, this essential resource offers a guide to the bidirectional interaction between laboratory and clinic immunotherapy cancer research.

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Produktdetails

• Verlag: John Wiley & Sons
• Seitenzahl: 312
• Erscheinungstermin: 12. Februar 2018
• Englisch
• ISBN-13: 9781118684528
• Artikelnr.: 52554277

Autorenporträt

Laurence J. N. Cooper, Associate Professor, Department of Pediatrics, The University of Texas MD Anderson Cancer Center, Houston, USA. Elizabeth A. Mittendorf, Professor, Department of Breast Surgical Oncology, The University of Texas MD Anderson Cancer Center, Houston, USA. Judy Moyes, Department of Pediatric Research, The University of Texas MD Anderson Cancer Center, Houston, USA. Sabitha Prabhakaran, Clinical Research Scientist, Department of Breast Surgical Oncology, The University of Texas MD Anderson Cancer Center, Houston, USA.

Inhaltsangabe

Editors
vi Contributors
vii Introduction
ix 1 Translation in Immunology: The Role of Translational Biomarkers to Guide Clinical Use of Immunotherapy for Cancer
1 Saranya Chumsri and Keith L. Knutson 2 Monoclonal Antibody Therapy
12 Elizabeth A. Mittendorf and Sabitha Prabhakaran 3 Somatic Mutations and Immunotherapy
24 Eric Tran 4 Checkpoint Blockade
37 Tracy A. Proverbs?]Singh
Jedd Wolchok
and Alexandra Snyder 5 Myeloid Leukemia Vaccines
54 Paul M. Armistead and Jonathan S. Serody 6 Cancer Vaccines for Solid Tumors
72 Timothy J. Vreeland
Garth S. Herbert
and George E. Peoples 7 Immunotherapy with Non-Genetically Modified T Cells
91 Cassian Yee 8 Immunotherapy with Genetically Modified T Cells
101 Liora Schultz and Crystal Mackall 9 Immunomodulation with Adjuvants and Cytokines
115 Dae won Kim and Adi Diab 10 Immune Cell Migration in Cancer and Immunotherapy
132 Timothy Murray and Daniel E. Speiser 11 Repurposing of Drugs for Immunotherapy
143 Jyothishmathi Swaminathan and Vidya Gopalakrishnan 12 Immunomodulation with Radiation
161 Jonathan E. Schoenhals
Taylor R. Cushman
Alexandra P. Cadena
Sandra Demaria
and James W. Welsh 13 Good Manufacturing Practices Facilities for Cellular Therapy
177 Andrew D. Fesnak and Bruce L. Levine 14 T Cell Receptor Mimic Antibodies
186 Gheath Alatrash and Jeffrey J. Molldrem 15 Stem Cell Transplantation for Treatment of Malignancy
201 Lohith S. Bachegowda and Richard E. Champlin 16 Natural Killer Cell-Based Immunotherapy
215 Jennifer A. Foltz
Jeffrey S. Miller
and Dean A. Lee 17 Immunologic Monitoring in Immuno?] Oncology
228 William R. Gwin and Mary L. Disis 18 Cell?]Based Therapies for Canine Cancer
252 Nicola J. Mason and M. Kazim Panjwani 19 Interaction between Targeted Therapy and Immunotherapy
268 Peter A. Prieto
Miles C. Andrews
Alexandria P. Cogdill
and Jennifer A. Wargo Index 286