Redaktion: Bast, Robert C.; Willman, Cheryl L.; Willett, Christopher G.; Tsimberidou, Apostolia-Maria; Pollock, Raphael E.; Khuri, Fadlo R.; Hawk, Ernest; Croce, Carlo M.; Byrd, John C.
Redaktion: Bast, Robert C.; Willman, Cheryl L.; Willett, Christopher G.; Tsimberidou, Apostolia-Maria; Pollock, Raphael E.; Khuri, Fadlo R.; Hawk, Ernest; Croce, Carlo M.; Byrd, John C.
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HOLLAND-FREI CANCER MEDICINE The latest edition of the gold-standard in cancer science and clinical oncology references In the newly revised Tenth Edition of Holland-Frei Cancer Medicine, a team of distinguished researchers and practitioners delivers a comprehensive and up-to-date discussion of cancer science and clinical oncology practice. The book contains timely and indispensable information on epidemiology, etiology, cancer biology, immunology, prevention, screening, clinical presentation, pathology, imaging, and therapy. Grounded in a fundamental understanding of cancer biology,…mehr
HOLLAND-FREI CANCER MEDICINE The latest edition of the gold-standard in cancer science and clinical oncology references In the newly revised Tenth Edition of Holland-Frei Cancer Medicine, a team of distinguished researchers and practitioners delivers a comprehensive and up-to-date discussion of cancer science and clinical oncology practice. The book contains timely and indispensable information on epidemiology, etiology, cancer biology, immunology, prevention, screening, clinical presentation, pathology, imaging, and therapy. Grounded in a fundamental understanding of cancer biology, Holland-Frei Cancer Medicine combines scientific principles with clinical practice. It contains hundreds of full-color illustrations and photographs, tables, graphs, and algorithms that complement and enhance the complex topics discussed within the book. This book is an invaluable clinical tool that provides readers with overview boxes, additional references, and other pedagogic features designed to make the content easy to access and comprehend. Readers will also find: * A translational and integrated approach throughout the book that combines cancer biology with cancer management * A strong emphasis on multidisciplinary, research-driven patient care that improves outcomes and allows for the optimal use of all clinically appropriate therapies * Discussions of the most current personalized cancer care, including molecular diagnostics and therapeutics Perfect for medical oncologists, radiation oncologists, and internists, Holland-Frei Cancer Medicine, Tenth Edition will also earn a place in the libraries of allied health professionals involved in the treatment of cancer patients. This book is published in collaboration with the American Association for Cancer Research: https://www.aacr.org
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Edited by Robert C. Bast Jr., MD, Vice President for Translational Research, The University of Texas MD Anderson Cancer Center, Houston, TX, USA John C. Byrd, MD, The Gordon and Helen Hughes Taylor Professor and Chair, Department of Internal Medicine, University of Cincinnati College of Medicine, Cincinnati, OH, USA Carlo Croce, MD, Distinguished University Professor, The Ohio State University, The John W. Wolfe Chair in Human Cancer Genetics, Professor and Chair, Department of Cancer Biology and Genetics The Wexner Medical Center, The Ohio State University, Columbus, OH, USA Ernest Hawk, MD, MPH, Vice President for Cancer Prevention & Head, Division of Cancer Prevention and Population Sciences, The University of Texas MD Anderson Cancer Center, Houston, TX, USA Fadlo R. Khuri, MD, President and Professor of Internal Medicine, Hematology and Medical Oncology, The American University of Beirut, Beirut, Lebanon Raphael Pollock, MD, PhD, FACS, Director, The Ohio State University Comprehensive Cancer Center, Kathleen Wellenreiter Klotz Chair in Cancer Research, The Ohio State University Wexner Medical Center, Columbus, OH, USA Apostolia M. Tsimberidou, MD, PhD, Professor, Department of Investigational Cancer Therapeutics, The University of Texas MD Anderson Cancer Center, Houston, TX, USA Christopher Willett, MD, Professor and Chair, Department of Radiation Oncology, Duke University School of Medicine, Boston, Massachusetts, USA Cheryl Willman, MD, Executive Director, Mayo Clinic Cancer Center Programs: Mayo Rochester/Midwest, Mayo Arizona, Mayo Florida, London, Abu Dhabi, Director, Mayo Clinic Comprehensive Cancer Center, Professor of Laboratory Medicine and Pathology, College of Medicine, Mayo Clinic Cancer Center, Rochester, NY, USA
Inhaltsangabe
List of contributors xi
Preface xxvii
Acknowledgments xxix
Part 1: INTRODUCTION
1 Cardinal manifestations of cancer 3
James F. Holland, Robert C. Bast, Jr., John C. Byrd,
Carlo M. Croce, Ernest Hawk, Fadlo R. Khuri, Raphael
E. Pollock, Apostolia M. Tsimberadou, Christopher G.
Willett, and Cheryl L.Willman
2 Biological hallmarks of cancer 7
Douglas Hanahan and Robert A.Weinberg
Part 2: TUMOR BIOLOGY
3 Molecular biology, genetics, and translational
models of human cancer 19
Benno Traub, Florian Scheufele, Srinivas R.
Viswanathan, Matthew Meyerson, and David A. Tuveson
4 Oncogenes 49
Marco A. Pierotti, Milo Frattini, Samantha Epistolio,
Gabriella Sozzi, and Carlo M. Croce
5 Tumor suppressor genes 73
Fred Bunz and Bert Vogelstein
6 Epigenetic contributions to human cancer 89
Stephen B. Baylin
7 Cancer genomics and evolution 101
William P. D. Hendricks, Aleksandar Sekulic, Alan H.
Bryce, Muhammed Murtaza, Pilar Ramos, Jessica D.
Lang, Timothy G. Whitsett, Timothy K. McDaniel,
Russell C. Rockne, Nicholas Banovich, and Jeffrey M. Trent
8 Chromosomal aberrations in cancer 125
Megan E. McNerney, Ari J. Rosenberg, and Michelle M.
Le Beau
9 MicroRNA expression in cancer 143
Serge P. Nana-Sinkam, Mario Acunzo, and Carlo M. Croce
10 Aberrant signaling pathways in cancer 151
Luca Grumolato and Stuart A. Aaronson
11 Differentiation therapy 161
Sai-Juan Chen, Xiao-Jing Yan, Guang-Biao Zhou, and
Zhu Chen
12 Cancer stem cells 177
Grace G. Bushnell,Michael D. Brooks, andMax S.Wicha
13 Cancer and cell death 187
John C. Reed
14 Cancer cell immortality: targeting telomerase and
telomeres 201
Ilgen Mender, Zeliha G. Dikmen, and JerryW. Shay
15 Cancer metabolism 211
Natalya N. Pavlova, Aparna D. Rao, Ralph J.
DeBerardinis, and Craig B.Thompson
16 Tumor angiogenesis 223
John V. Heymach, Amado Zurita-Saavedra, Scott
Kopetz, Tina Cascone, MoniqueNilsson, and IreneGuijarro
Part 3: QUANTITATIVE ONCOLOGY
17 Cancer bioinformatics 247
John N.Weinstein
18 Systems biology and genomics 261
Saima Hassan, Joe W. Gray, and LauraM.Heiser
19 Statistical innovations in cancer research 269
J. Jack Lee and Donald A. Berry
20 Biomarker based clinical trial design in the era of
genomic medicine 285
R.Donald Harvey, Yuan Liu, Taofeek K.Owonikoko,
and Suresh S. Ramalingam
21 Clinical and research informatics data strategy for
precision oncology 293
Douglas Hartman, Uma Chandran, Michael Davis,
Rajiv Dhir,William E. Shirey, Jonathan C. Silverstein,
and Michael J. Becich
Part 4: CARCINOGENESIS
22 Chemical carcinogenesis 305
Lorne J. Hofseth, AinsleyWeston, and Curtis C. Harris
23 Ionizing radiation 325
David J. Grdina
24 Ultraviolet radiation carcinogenesis 333
James E. Cleaver, Susana Ortiz-Urda, and Sarah Arron
25 Inflammation and cancer 339
Jelena Todoric, Atsushi Umemura, Koji Taniguchi, and
