John P. Sundberg

Handbook of Mouse Mutations with Skin and Hair Abnormalities (eBook, PDF)

Animal Models and Biomedical Tools

• Format: PDF

Produktbeschreibung

Handbook of Mouse Mutations with Skin and Hair Abnormalities presents 48 mouse mutations that are all available to the biomedical community. Many of the mouse mutations with dermatological diseases are reviewed and illustrated in detail. This popular reference book gives you a single source to use when determining which mouse mutation will best serve your needs as a biomedical tool for sophisticated research projects.

The book also includes an overview of domestic animal genodermatoses to provide alternatives to mouse models that do not exist or to complement those that do. A detailed section written by renowned experts compares the biology of human and mouse skin and skin diseases in the areas of development and the use of animal models, mammalian genetics, keratin biochemistry, epidermal and hair follicle cycles and kinetics, cytokines and growth factors, keratinocyte culture systems, cutaneous carcinogenesis, cutaneous immune system, and skin changes associated with mutations of the endocrine system.

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Produktdetails

• Verlag: Taylor & Francis
• Seitenzahl: 576
• Erscheinungstermin: 26. August 2020
• Englisch
• ISBN-13: 9781000099300
• Artikelnr.: 59898719

Autorenporträt

John P. Sundberg, D.V.M., Ph.D., is Head of the Pathology program at the Jackson Laboratory in Bar Harbor, Maine. Dr. Sundberg graduated in 1973 from the University of Vermont with a B.S. degree in Animal Science (summa cum laude) and obtained his D.V.M. degree in 1977 from Purdue University School of Veterinary Medicine, West Lafayette, Indiana. Following a brief period in private practice. Dr. Sundberg earned a Ph.D. degree in comparative pathology in 1981 from The University of Connecticut in Storrs. Dr. Sundberg served as an assistant professor at the University of Illinois College of Veterinary Medicine from 1981 to 1986. In 1986 he assumed his present position. Dr. Sundberg is a diplomate of the American College of Veterinary Pathologists. He is a member of the American Veterinary Medical Association, American Association for Laboratory Animal Science, Society for Investigative Dermatology, Hair Research Society, New England Veterinary Pathology Colloquy, and the Maine Veterinary Medical Association. Dr. Sundberg has been the recipient of research grants from the National Institutes of Health, American Cancer Society, National Alopecia Areata Foundation, and private industry. He has published over 125 research and clinical papers, 50 technical bulletins, and 15 book chapters. His current major research interests relate to mouse mutations as models of human and animal diseases, the comparative pathology and molecular evolution of nonhuman papillomaviruses, and spontaneous diseases of inbred laboratory mice.

Inhaltsangabe

PART I. BIOLOGY OF SKIN AND HAIR OF LABORATORY MICE AND HUMAN BEINGS
Introduction
Chapter 1. Applications and Needs of Models for Dermatological Research /Lowell A. Goldsmith
Chapter 2. Inbred Laboratory Mice as AnimaJ Models and Biomedical Tools: General Concepts /John P. Sundberg
Chapter 3. The Jackson Laboratory Mouse Mutant Resource /Muriel T. Davisson
Chapter 4. Hair Follicle Stem Cells /Robert M. Lavker, Tung
Tien Sun, and John P. Sundberg
Chapter 5. The Mouse Skin as a Model for Chemical Carcinogenesis /Claudio J. Conti
Chapter 6. Viral Induced Skin Tumors in Mice /John P. Sundberg, Hendrick G. Bedigian, and Roderick Bronson
Chapter 7. Hair Types and Subtypes in the Laboratory Mouse /John P. Sundberg and Margaret E. Hogan
Chapter 8. Growth Factors and Cutaneous Pathology /Lloyd E. King, Jr., Lillian B. Nanney, and Ronald E. Gates
Chapter 9. Transgenic Mice with Cytokine Mutations Affecting the Skin /Manfred Blessing, Erby Wilkinson, and Brigid L. M. Hogan
Chapter 10. Epidermal Keratins /Joseph A. Rothnagel and Dennis R. Roop
Chapter 1 1. Hair Follicle Keratins /George E. Rogers and Barry C. Powell
Chapter 12. Keratinocyte Cultures as Models for DermatologicaJ Disease /Mark R. Pittelkow
Chapter 13. Mouse Mutations with Endocrine Functional Consequences /Wesley G. Beamer
Chapter 14. The Immune System in Cutaneous Disease: the Search for a Mouse Model of the Lmmunopathology of Psoriasis /Susan F. Grammer and J. Wayne Streilein
PART II. ANIMAL MODELS OF GENETIC BASED SKIN DISEASES Section A. Mouse Single Gene Mutations
Introduction
Chapter 1. The Adrenocortical Dysplasia (acd) Mutation, Chromosome 8 /John P. Sundberg, Seth J. Orlow, Hope O. Sweet, and Wesley G. Beamer
Chapter 2. The Angora (go) Mutation, Chromosome 5 /John P. Sundberg
Chapter 3. The Asebia (ab, ab1) Mutations, Chromosome 19 /John P. Sundberg
Chapter 4. The Atrichosis (at) Mutation, Chromosome 10 /John P. Sundberg
Chapter 5. The Balding (bal) Mutation, Chromosome 18 /John P. Sundberg
Chapter 6. The Bare
Patches (Bpa) Mutation, Chromosome X /John P. Sundberg
Chapter 7. The Bareskin (Bsk) Mutation, Chromosome 11 /John P. Sundberg
Chapter 8. The Beige (bg) Mutation, Chromosome 13 /John P. Sundberg
Chapter 9. The Caracul (Ca and Cad) Mutations, Chromosome 15 /John P. Sundberg and Hope O. Sweet
Chapter 10. The Chronic Proliferative Dermatitis (cpd) Mutation, Chromosome ?. Harm HogenEsch, Marion J. J. Gijbels, and Chris Zurcher
Chapter 11. The Crinkled (cr) Mutation, Chromosome 13 /John P. Sundberg
Chapter 12. The Curly
Whiskers (cw) Mutation, Chromosome 9 /John P. Sundberg
Chapter 13. The Depilated (dep) Mutation, Chromosome 4 /John P. Sundberg and Seth J. Orlow
Chapter 14. The Downless (dl) and Sleek (Dlslk) Mutations, Chromosome 10 /John P. Sundberg
Chapter 15. The Ferrochelatase Deficiency (FechmlPas) Mutation, Chromosome 18 /Xavier Montagutelli
Chapter 16. The Flaky Skin (fsn) Mutation, Chromosome? /John P. Sundberg, Dawnalyn Boggess, Leonard D. Shultz, and Wesley G. Beamer
Chapter 17. The Flaky Tail (ft) Mutation, Chromosome 3 /John P. Sundberg
Chapter 18. The Frizzy (fr) Mutation, Chromosome 7 /John P. Sundberg
Chapter 19. The Fuzzy (fz) Mutation, Chromosome 1 /John P. Sundberg
Chapter 20. The Greasy (Gs) Mutation, Chromosome X /John P. Sundberg
Chapter 21. The Hair Interior Defect (hid) Mutation, Chromosome? /John P. Sundberg
Chapter 22. The Hairless (hr) and Rhino (hrrh) Mutations, Chromosome 14 /John P. Sundberg
Chapter 23. The Hair Patches (Hpt) Mutation, Chromosome 4 /John P. Sundberg
Chapter 24. The Hairy Ears (Eh) Mutation, Chromosome 15 /John P. Sundberg and Seth J. Orlow
Chapter 25. The Harlequin (Hq) Mutation, Chromosome X /John P. Sundberg
Chapter 26. The Ichthyosis (ic) Mutation, Chromosome 1 /John P. Sundberg and Mark R. Pittelkow
Chapter 27. The Lethal Milk (Im) Mutation, Chromosome 2 /John P. Sundberg and Hope O. Sweet
Chapter 28. The Lustrous ( / /) Mutation, Chromosome 11 /John P. Sundberg
Chapter 29. The Matted (ma) Mutation, Chromosome 3 /John P. Sundberg
Chapter 30. The Motheaten (me) and Viable Motheaten (mev) Mutations, Chromosome 6 /Leonard D. Shultz and John P. Sundberg
Chapter 31. The Mottled Locus: Mottled (Mo), Blotchy (Mobl°), Brindled (Mobr), Dappled (Modp), Mosaic (Moms), Tortoiseshell (Mow), and Viable Brindled (Movbr) Mutations, Chromosome X /
John P. Sundberg
Chapter 32. The Naked (N) Mutation, Chromosome 15 /John P. Sundberg
Chapter 33. The Nude (nu) and Streaker (nustr) Mutations, Chromosome 11 /John P. Sundberg
Chapter 34. The Ragged (Ra) and Opossum (Raop) Mutations, Chromosome 2 /John P. Sundberg
Chapter 35. The Repeated Epilation (Er) Mutation, Chromosome 4 /Jean
Louis Guenet, Josselyne Salaun, and Berthe Salzgeber
Chapter 36. The Rex (Re), Wavy Coat (Rewl), and Denuded (Reden) Mutations, Chromosome 11 /John P. Sundberg
Chapter 37. The Satin (sa) Mutation, Chromosome 13 /John P. Sundberg
Chapter 38. The Scurfy (sf) Mutation, Chromosome X /Virginia L. Godfrey
Chapter 39. The Severe Combined Immunodeficiency (scid) Mutation, Chromosome 16 /John P. Sundberg and Leonard D. Shultz
Chapter 40. The Shaven (Sha) Mutation, Chromosome 15 /John P. Sundberg
Chapter 41. The Silver (si) Mutation, Chromosome 10 /Seth J. Orlow and John P. Sundberg
Chapter 42. The Soft Coat (soc) Mutation, Chromosome 3 /John P. Sundberg
Chapter 43. The Sparse
Coat (spc) Mutation, Chromosome 14 /John P. Sundberg
Chapter 44. The Sparse
Fur (Otcspf) and Abnormal Skin and Hair (Otcash) Mutations, Chromosome X /John P. Sundberg and Donald P. Doolittle
Chapter 45. The Tabby (Ta), Tabby
c (Tal), and Tabby
J (TaJ) Mutations, Chromosome X /John P. Sundberg
Chapter 46. The Tight
Skin (Tsk) Mutation, Chromosome 2 /John P. Sundberg
Chapter 47. The Vitiligo (mivu) Mutant Allele of the Microphthalmia Locus, Chromosome 6 /M. Lynn Lamoreux and Seth J. Orlow
Chapter 48. The Wellhaarig (we, weMr) Mutations, Chromosome 2 /John P. Sundberg
Section B. Purported Polygenic Mouse Skin Diseases
Introduction
Chapter 1. Chronic Ulcerative Dermatitis in Black Mice /John P. Sundberg, Kathy S. Brown, and William M. McMahon
Chapter 2. Barbering Behavioral Abnormalities in Inbred Laboratory Mice /William M. McMahon and John P. Sundberg
Chapter 3. Alopecia Areata in Aging C3H /HeJ Mice /John P. Sundberg, Colleen M. Vallee, and Lloyd E. King, Jr.
Section C. Nonmurine Animal Models of Genetic Based Skin Diseases
Chapter 1. Selected Heritable Skin Diseases of Domesticated Animals /Robert W. Dunstan and Robert A. Kennis
Index.