James C. Barton

Handbook of Iron Overload Disorders (eBook, PDF)

• Format: PDF

Produktbeschreibung

A practical, clinically-oriented handbook of iron overload disorders giving a compact guide to normal iron metabolism, iron-related pathobiology, and the diagnosis and management of heritable and acquired iron overload disorders. Many of these disorders were discovered and characterized only in the last decade, and are unmentioned or inadequately described in most texts. Written by clinicians for clinicians, this handbook summarizes information on diverse iron overload conditions, including their history, signs, symptoms, physical examination findings, genetics, genotype-phenotype correlations, pathophysiology, differential diagnosis and treatment. Most physicians, regardless of specialty, encounter patients with systemic or organ-specific iron overload conditions. This book contains essential information for practising adult and pediatric medical specialists in the fields of hematology, gastroenterology, hepatology, rheumatology, endocrinology, diabetology, neurology, oncology, dermatology and internal medicine. Pathologists, pharmacologists, geneticists, genetic counselors and epidemiologists will also find substantial, up-to-date sections in this handbook that are pertinent to their respective fields of interest.

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Produktdetails

• Verlag: Cambridge University Press
• Erscheinungstermin: 22. Juli 2010
• Englisch
• ISBN-13: 9780511771460
• Artikelnr.: 38194795

Autorenporträt

James C. Barton is Medical Director, Southern Iron Disorders Center and Clinical Professor, Department of Medicine, University of Alabama at Birmingham, Birmingham, Alabama, USA.

Inhaltsangabe

Foreword
Preface
1. History of iron overload disorders
2. Normal iron absorption and metabolism
3. Iron toxicity
4. Tests for hemochromatosis and iron overload
5. Complications of hemochromatosis and iron overload
6. Insulin resistance and iron overload
7. Infections and immunity
8. Classical and atypical hfe hemochromatosis
9. Heterozygosity for hfe c282y
10. Porphyria cutanea tarda
11. Mitochondrial mutations as modifiers of hemochromatosis
12. Hemochromatosis associated with ferroportin gene (slc40a1) mutations
13. Hemochromatosis associated with hemojuvelin gene (hjv) mutations
14. Hemochromatosis associated with hepcidin gene (hamp) mutations
15. Hemochromatosis associated with transferrin receptor-2 gene (tfr2) mutations
16. Iron overload associated with ire mutation of ferritin heavy-chain gene (fth1)
17. Hereditary hyperferritinemia-cataract syndrome: ire mutations of ferritin light chain gene (ftl)
18. Iron overload in native Africans and African Americans
19. Hereditary atransferrinemia
20. Divalent metal transporter-1 (dmt1) iron overload
21. Iron overload associated with thalassemia syndromes
22. Iron overload associated with hemoglobinopathies
23. Iron overload associated with pyruvate kinase deficiency
24. Iron overload associated with congenital dyserythropoietic anemias
25. Hereditary sideroblastic anemias
26. Pearson marrow-pancreas syndrome
27. Acquired sideroblastic anemias
28. Hereditary aceruloplasminemia
29. Friedreich ataxia and cardiomyopathy
30. Pantothenate kinase (pank2)-associated neurodegeneration
31. Neuroferritinopathies
32. Gracile syndrome
33. Neonatal hemochromatosis
34. Iron overload due to excessive supplementation
35. Localized iron overload
36. Management of iron overload
37. Population screening for hemochromatosis
38. Ethical, legal, and social issues
39. Directions for future research
Index.