GPCRs (eBook, ePUB)

Structure, Function, and Drug Discovery
Redaktion: Jastrzebska, Beata; Park, Paul S. -H.

• Format: ePub

Produktbeschreibung

GPCRS: Structure, Function, and Drug Discovery provides a comprehensive overview of recent discoveries and our current understanding of GPCR structure, signaling, physiology, pharmacology and methods of study. In addition to the fundamental aspects of GPCR function and dynamics, international experts discuss crystal structures, GPCR complexes with partner proteins, GPCR allosteric modulation, biased signaling through protein partners, deorphanization of GPCRs, and novel GPCR-targeting ligands that could lead to the development of new therapeutics against human diseases. GPCR association with, and possible therapeutic pathways for, retinal degenerative diseases, Alzheimer's disease, Parkinson's disease, cancer and diabetic nephropathy, among other illnesses, are examined in-depth.

• Addresses our current understanding and novel advances in the GPCR field, directing readers towards recent finding of key significance for translational medicine
• Combines a thorough discussion of structure and function of GPCRs with disease association and drug discovery
• Features chapter contributions from international experts in GPCR structure, signaling, physiology and pharmacology

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Produktdetails

• Verlag: Elsevier Science & Techn.
• Seitenzahl: 500
• Erscheinungstermin: 11. September 2019
• Englisch
• ISBN-13: 9780128167281
• Artikelnr.: 68434265

Inhaltsangabe

Part I GPCR structure 1. Progress in GPCR structure Determination 2.
Structure, function and therapeutic potential of adhesion GPCRs 3.
Structural diversity in ligand recognition by GPCRs 4. NMR-based approaches
to the study of GPCRs and GPCR-ligand interactions 5. Supramolecular
structure of opsins 6. Molecular determinants of GPCR oligomerization 7.
Structure of G-protein-coupled receptor heteromers 8. Class A GPCR
oligomerization: reasons of controversy
Part II GPCR function 9. Quantifying GPCR allostery and biased signaling
10. Kinetics of ligand binding and signaling 11. Allosteric modulators
targeting GPCRs 12. Arrestin-mediated signaling at GPCRs 13. Organellar Gb?
signaling - GPCR signaling beyond the cell surface
Part III GPCRs in disease and targeted drug discovery 14. G protein-coupled
receptor allosteric modulators: understanding modulator affinity and
pharmacological dose 15. Computer-aided GPCR drug discovery 16. Tackling
the complexities of orphan GPCR ligand discovery with rationally assisted
approaches 17. G protein-coupled receptors in neurodegenerative diseases
18. GPCR targets in type 2 diabetes 19. GPCRs in thromboinflammation and
hemostasis 20. Angiotensin II receptors: structure-function and drug
discovery 21. GPCRs in innate and adaptive immune responses 22. Role of
GPCRs in cancer