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Genetics, Neurology, Behavior, and Diet in Parkinson's Disease: The Neuroscience of Parkinson's Disease, Volume 2 provides a single source of material covering different scientific domains of neuropathology underlying this condition. The book covers a wide range of subjects and unravels the complex relationships between genetics, molecular biology, pharmaceutical chemistry, neurobiology, imaging, assessments, and treatment regimens. It fills a much-needed gap as a "one-stop" synopsis of everything to do with the neurology and neuroscience related to Parkinson's disease-from chemicals and…mehr
Genetics, Neurology, Behavior, and Diet in Parkinson's Disease: The Neuroscience of Parkinson's Disease, Volume 2 provides a single source of material covering different scientific domains of neuropathology underlying this condition. The book covers a wide range of subjects and unravels the complex relationships between genetics, molecular biology, pharmaceutical chemistry, neurobiology, imaging, assessments, and treatment regimens. It fills a much-needed gap as a "one-stop" synopsis of everything to do with the neurology and neuroscience related to Parkinson's disease-from chemicals and cells to individuals. It is an invaluable resource for neuroscientists, neurologists, and anyone in the field.
Offers the most comprehensive coverage of a broad range of topics related to Parkinson's disease
Serves as a foundational collection for neuroscientists and neurologists on the biology of disease and brain dysfunction
Contains in each chapter an abstract, key facts, mini dictionary of terms, and summary points to aid in understanding
Features preclinical and clinical studies to help researchers map out key areas for research and further clinical recommendations
Serves as a "one-stop" source for everything you need to know about Parkinson's disease
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Part I: Genetics, molecular and cellular biology 2. Alpha-synuclein gene and Parkinson's diseaseAthina-Maria Simitsi, Chistos Koros and Leonidas Stefanis 3. The DJ-1 gene and protein: links with Parkinson's diseaseVanessa J. Musco, Sarah J. Annesley and Paul R. Fisher 4. Regulation of tyrosine hydroxylase: relevance to Parkinson's diseaseGelareh Alam and Jason R. Richardson 5. Linking glucocerebrosidase gene (GBA) variants and Parkinson's diseasectoria Berge-Seidl and Mathias Toft 6. Astrocytes and microglia in Parkinson's disease and animal modelsKatarzyna Kuter 7. The role of autophagy in Parkinson's disease etiopathogenesisEmanuel Candeias, Jãao Duarte Magalhães, Daniel Santos, Helena Costa, Diana F. Silva, Ana Raquel Esteves and Sandra Morais Cardoso 8. The mitochondrial network in Parkinson's diseaseAndreas Aufschnaiter, Verena Kohler and Sabrina Büttner 9. Signal transduction in Parkinson's disease: modulation of neurotransmission, symptomatology, and therapyMattia Volta 10. Oxidative stress signaling and regulated cell death in Parkinson's diseaseCarlos Velez-Pardo and Marlene Jimenez-Del-Rio 11. Subcellular-specific alpha-synuclein in Parkinson's diseaseBenjamin Rosen, Ketan S. Patil, Guido W. Alves and Simon G. Møller 12. Melanocortin 1 receptor: Parkinson's disease, melanoma risk, and neuroprotectionGemma Tell-Marti, Joan Anton Puig-Butillé and Susana Puig 13. Energy regulation and Parkinson's diseaseLiting Hang and Kah-Leong Lim 14. Linking rotigotine, Parkinson's disease, and brain-derived neurotrophic factorKazuhiro Sohya, Kazunori O'Hashi and Hiroshi Kunugi Part II: Neurology, physiology and imaging 15. The different syndromes in Parkinson's disease: an overviewNikolaos Giagkou and Maria Stamelou 16. Neuromolecular imaging in Parkinson's diseasePatricia A. Broderick and Leslie Wenning 17. Interlinking brain mapping and Parkinson's disease: MRI analysis, nigrosome 1 and nigrosome 4Eung Yeop Kim, Young Hee Sung and Jongho Lee 18. Interconnecting Parkinson's disease: the use of computed tomography and microelectrode recording in DBS surgeryRyan B. Kochanski and Sepehr Sani 19. Linking diffusion tensor imaging, microstructures and Parkinson's diseaseYu Zhang, Norbert Schuff, I-Wei Wu and Duygu Tosun 20. Detecting parkinsonian degeneration in lateroventral tier of substantia nigra pars compacta with MRIJason Langley, Daniel E. Huddleston and Xiaoping P. Hu 21. Vagal motoneurons in Parkinson's diseaseRuth E. Musgrove, Wei-Hua Chiu and Joshua A. Goldberg 22. Circadian clock disruption and neuroinflammation in Parkinson's disease: a new perspective Elisabetta Lauretti and Domenico Praticò 23. Motor cortex stimulation in Parkinson's diseaseAngelo Lavano, Giusy Guzzi, Attilio Della Torre and Domenico La Torre 24. Action programming disorders associated with Parkinson's diseaseKenneth M. Heilman 25. The striatal medium spiny neurons: what they are and how they link with Parkinson's diseaseFu-Ming Zhou 26. Disruptions of frontostriatal language functions in Parkinson's diseaseAdolfo M. García, Yamile Bocanegra, Agustina Birba, Juan Rafael Orozco-Arroyave, Lucas Sedeño and Agustín Ibañez 27. Alpha-synuclein and neuroinflammation in Parkinson's diseaseTatiana Varanita and Luigi Bubacco 28. Tau and its interactions with other proteins in neurodegenerative diseasesKatelyn H. Mroczek, Sarah J. Annesley and Paul R. Fisher 29. Interaction between brain angiotensin and dopaminergic systems and Parkinson's diseaseJose Luis Labandeira-Garcia, Pablo Garrido-Gil, Maria A. Pedrosa, Carmen M. Labandeira and Ana I. Rodriguez-Perez 30. Restoring dopamine levels in Parkinson's disease: neuronal pathways, agonists and antiinflammatory agentsÁgatha Oliveira-Giacomelli, C.M. Albino, Hellio Danny Nóbrega de Souza and Henning Ulrich Part III: Behaviour and psychopathology 31. Motivation and motivational aspects of Parkinson's diseaseAbdeslam Chagraoui, Emilie Puginier and Philippe De Deurwaerdère 32. Linking anxiety, cognitive and sensory deficits to gait and balance deficits in Parkinson's diseaseQuincy J. Almeida 33. Motor programs interlinking gait and bradykinesia in Parkinson's diseaseTateo Warabi, Kiyoharu Inoue and Nobuo Yanagisawa 34. Olfactory disturbances in Parkinson's diseaseLais S. Rodrigues, Juliane Fagotti, Adriano D.S. Targa, Ana Carolina D. Noseda, Jessica L. Ilkiw, Flavia W.C. Dorieux and Marcelo M.S. Lima 35. Interlinking dementia in Parkinson's disease: nutritional correlates of body compositionArthur Oscar Schelp, Jéssica Emy Komuro, José Eduardo Corrente and Silvia Justina Papini 36. The role of the gastrointestinal system and gut microbiota in Parkinson's diseaseJade Kenna and Ryan S. Anderton 37. Swallowing impairment in Parkinson's diseaseMaira Rozenfeld Olchik, Marina Padovani and Annelise Ayres 38. The Mini Nutritional Assessment (MNA) and applications to Parkinson's diseaseSvetlana Tomic 39. The efficacy of Bacopa monnieri extract in modulating Parkinson's diseaseDr. Ravikumar Hosamani Part V: Models, modelling and resources 40. 6-hydroxydopamine-induced model of Parkinson's diseaseKatarzyna Kaczynska and Kryspin Andrzejewski 41. Knockdown transgenic Drosophila and Parkinson's diseaseMarlene Jimenez-Del-Rio and Carlos Velez-Pardo 42. Neuroprotection in animal models of Parkinson's disease: exploring exercise, sound, and lightJohn Mitrofanis 43. Modeling with the A53T a-synuclein model of Parkinson's diseaseThomas Musacchio, James B. Koprich and Chi Wang Ip 44. Linking the leucine-rich repeat kinase 2 gene, animal models, and Parkinson's diseaseYulan Xiong and Jianzhong Yu 45. Neuroscience of Parkinson's disease: recommended reading and resourcesRajkumar Rajendram, Vinood B. Patel and Victor R. Preedy
Part I: Genetics, molecular and cellular biology 2. Alpha-synuclein gene and Parkinson's diseaseAthina-Maria Simitsi, Chistos Koros and Leonidas Stefanis 3. The DJ-1 gene and protein: links with Parkinson's diseaseVanessa J. Musco, Sarah J. Annesley and Paul R. Fisher 4. Regulation of tyrosine hydroxylase: relevance to Parkinson's diseaseGelareh Alam and Jason R. Richardson 5. Linking glucocerebrosidase gene (GBA) variants and Parkinson's diseasectoria Berge-Seidl and Mathias Toft 6. Astrocytes and microglia in Parkinson's disease and animal modelsKatarzyna Kuter 7. The role of autophagy in Parkinson's disease etiopathogenesisEmanuel Candeias, Jãao Duarte Magalhães, Daniel Santos, Helena Costa, Diana F. Silva, Ana Raquel Esteves and Sandra Morais Cardoso 8. The mitochondrial network in Parkinson's diseaseAndreas Aufschnaiter, Verena Kohler and Sabrina Büttner 9. Signal transduction in Parkinson's disease: modulation of neurotransmission, symptomatology, and therapyMattia Volta 10. Oxidative stress signaling and regulated cell death in Parkinson's diseaseCarlos Velez-Pardo and Marlene Jimenez-Del-Rio 11. Subcellular-specific alpha-synuclein in Parkinson's diseaseBenjamin Rosen, Ketan S. Patil, Guido W. Alves and Simon G. Møller 12. Melanocortin 1 receptor: Parkinson's disease, melanoma risk, and neuroprotectionGemma Tell-Marti, Joan Anton Puig-Butillé and Susana Puig 13. Energy regulation and Parkinson's diseaseLiting Hang and Kah-Leong Lim 14. Linking rotigotine, Parkinson's disease, and brain-derived neurotrophic factorKazuhiro Sohya, Kazunori O'Hashi and Hiroshi Kunugi Part II: Neurology, physiology and imaging 15. The different syndromes in Parkinson's disease: an overviewNikolaos Giagkou and Maria Stamelou 16. Neuromolecular imaging in Parkinson's diseasePatricia A. Broderick and Leslie Wenning 17. Interlinking brain mapping and Parkinson's disease: MRI analysis, nigrosome 1 and nigrosome 4Eung Yeop Kim, Young Hee Sung and Jongho Lee 18. Interconnecting Parkinson's disease: the use of computed tomography and microelectrode recording in DBS surgeryRyan B. Kochanski and Sepehr Sani 19. Linking diffusion tensor imaging, microstructures and Parkinson's diseaseYu Zhang, Norbert Schuff, I-Wei Wu and Duygu Tosun 20. Detecting parkinsonian degeneration in lateroventral tier of substantia nigra pars compacta with MRIJason Langley, Daniel E. Huddleston and Xiaoping P. Hu 21. Vagal motoneurons in Parkinson's diseaseRuth E. Musgrove, Wei-Hua Chiu and Joshua A. Goldberg 22. Circadian clock disruption and neuroinflammation in Parkinson's disease: a new perspective Elisabetta Lauretti and Domenico Praticò 23. Motor cortex stimulation in Parkinson's diseaseAngelo Lavano, Giusy Guzzi, Attilio Della Torre and Domenico La Torre 24. Action programming disorders associated with Parkinson's diseaseKenneth M. Heilman 25. The striatal medium spiny neurons: what they are and how they link with Parkinson's diseaseFu-Ming Zhou 26. Disruptions of frontostriatal language functions in Parkinson's diseaseAdolfo M. García, Yamile Bocanegra, Agustina Birba, Juan Rafael Orozco-Arroyave, Lucas Sedeño and Agustín Ibañez 27. Alpha-synuclein and neuroinflammation in Parkinson's diseaseTatiana Varanita and Luigi Bubacco 28. Tau and its interactions with other proteins in neurodegenerative diseasesKatelyn H. Mroczek, Sarah J. Annesley and Paul R. Fisher 29. Interaction between brain angiotensin and dopaminergic systems and Parkinson's diseaseJose Luis Labandeira-Garcia, Pablo Garrido-Gil, Maria A. Pedrosa, Carmen M. Labandeira and Ana I. Rodriguez-Perez 30. Restoring dopamine levels in Parkinson's disease: neuronal pathways, agonists and antiinflammatory agentsÁgatha Oliveira-Giacomelli, C.M. Albino, Hellio Danny Nóbrega de Souza and Henning Ulrich Part III: Behaviour and psychopathology 31. Motivation and motivational aspects of Parkinson's diseaseAbdeslam Chagraoui, Emilie Puginier and Philippe De Deurwaerdère 32. Linking anxiety, cognitive and sensory deficits to gait and balance deficits in Parkinson's diseaseQuincy J. Almeida 33. Motor programs interlinking gait and bradykinesia in Parkinson's diseaseTateo Warabi, Kiyoharu Inoue and Nobuo Yanagisawa 34. Olfactory disturbances in Parkinson's diseaseLais S. Rodrigues, Juliane Fagotti, Adriano D.S. Targa, Ana Carolina D. Noseda, Jessica L. Ilkiw, Flavia W.C. Dorieux and Marcelo M.S. Lima 35. Interlinking dementia in Parkinson's disease: nutritional correlates of body compositionArthur Oscar Schelp, Jéssica Emy Komuro, José Eduardo Corrente and Silvia Justina Papini 36. The role of the gastrointestinal system and gut microbiota in Parkinson's diseaseJade Kenna and Ryan S. Anderton 37. Swallowing impairment in Parkinson's diseaseMaira Rozenfeld Olchik, Marina Padovani and Annelise Ayres 38. The Mini Nutritional Assessment (MNA) and applications to Parkinson's diseaseSvetlana Tomic 39. The efficacy of Bacopa monnieri extract in modulating Parkinson's diseaseDr. Ravikumar Hosamani Part V: Models, modelling and resources 40. 6-hydroxydopamine-induced model of Parkinson's diseaseKatarzyna Kaczynska and Kryspin Andrzejewski 41. Knockdown transgenic Drosophila and Parkinson's diseaseMarlene Jimenez-Del-Rio and Carlos Velez-Pardo 42. Neuroprotection in animal models of Parkinson's disease: exploring exercise, sound, and lightJohn Mitrofanis 43. Modeling with the A53T a-synuclein model of Parkinson's diseaseThomas Musacchio, James B. Koprich and Chi Wang Ip 44. Linking the leucine-rich repeat kinase 2 gene, animal models, and Parkinson's diseaseYulan Xiong and Jianzhong Yu 45. Neuroscience of Parkinson's disease: recommended reading and resourcesRajkumar Rajendram, Vinood B. Patel and Victor R. Preedy
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